Reanimación cardiocerebral intrahospitalaria

Beneyto, Luis Alberto Pallás; Luis, Olga Rodríguez; Bayarri, Vicente Miguel

doi:10.1016/j.medcli.2011.05.012

Cited by 5 publications

(1 citation statement)

References 47 publications

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“…Hemos leído con interé s el artículo titulado Reanimación cerebral intrahospitalaria, recientemente publicado por Pallá s Beneyto et al 1 . Nos gustaría hacer algunos comentarios, basá ndonos en las guías sobre reanimació n cardiopulmonar (RCP) del European Resuscitation Council (ERC) 2 y la American Heart Association (AHA) 3 , seguidas por el Consejo Españ ol de Resucitació n Cardiopulmonar.…”

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Reanimación cardiocerebral intrahospitalaria

2012

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Reanimación cardiocerebral intrahospitalaria

2012

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Effects of Mild and Moderate Hypothemia Therapy on Expression of Cerebral Neuron Apoptosis Related Proteins and Glial Fiber Acidic Protein After Rat Cardio-pulmonary Resuscitation

Ding

Gao

et al. 2014

Cell Biochem Biophys

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To explore the effects of different degrees of hypothermia on brain tissue apoptosis after cardio-pulmonary resuscitation (CPR). Cardiac arrest for 5 min induced by asphyxia method was used to create CPR model. 30 SD rats were randomly divided into control group (normothermia), 33 °C hypothermia group and 30 °C hypothermia group with ten rats in each. Rats in control group received routine treatment at 25 °C room temperature after CPR; Rats in mild hypothermia and moderate hypothermia groups were given hypothermia treatment 0.5 h after CPR. Brain tissue in all groups was taken 24 h after CPR, and immunohistochemistry was used to detect the caspase-3 in cerebral cortex and glial fiber acidic protein (GFAP) expression in astrocyte. Western blotting was used to detect Bcl-2 and Bax protein expression, and histopathological change was observed in brain tissue. Compare to the control group, caspase-3 expression in cerebral neurons in hypothermia group was significantly decreased (p<0.01), which was significantly lower in 30 °C group than that in 33 °C group (p > 0.05); GFAP level in hypothermia groups was significantly increased (p < 0.01), which was higher in 30 °C hypothermia group than that in 33 °C hypothermia group (p < 0.05); Bcl-2 expression level in hypothermia group was significantly increased (p < 0.01), which was higher in 30 °C hypothermia group than that in 33 °C hypothermia group (p < 0.05); The level of Bax had no significant difference among the three groups. Hypothermia-regulated GFAP expression by decreasing caspase-3 expression and increasing Bcl-2 expression to promote brain cell signaling transduction, and further inhibited cell apoptosis and reduced brain injury. Moderate hypothermia therapy is more effective than mild hypothermia in preventing brain injure.

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