In the present study, we conducted four experiments to explore how state anxiety influences attentional bias, and vice versa, as well as the moderating effect of cognitive appraisal in this relationship. Experiment 1 focused on whether induced state anxiety could lead to attentional bias. Experiment 2 explored the influence of attentional bias on state anxiety under stressful conditions. Experiments 3 and 4 investigated the moderating effect of cognitive appraisal on the interaction between state anxiety and attentional bias. Our main findings were that state anxiety directly leads to attentional bias, whereas negative attentional bias increases state anxiety under stressful conditions. Moreover, cognitive appraisal moderates the influence of attentional bias on state anxiety, but not the reverse influence. The implications of our study are that it provides empirical evidence for the interaction between state anxiety and attentional bias, and also that it offers insight into the different moderating effects of cognitive appraisal on the relationship. Keywords State anxiety. Attentional bias. Cognitive appraisal. Interaction. Moderating effect Many people suffer from the dysfunction of anxiety. Given the ubiquitous nature of anxiety, a thorough understanding of its causes is imperative. However, despite the importance of this topic, fundamental questions remain about how anxiety is maintained and exacerbated over time. Among many possible causes, there is a consensus at the theoretical level that anxiety is associated with biases in processing threat-related information (Eysenck, 1992; Mogg & Bradley, 1998; Williams, Watts, MacLeod, & Mathews, 1997). Specifically, the attentional system of anxious individuals is distinctively biased in favor of threat-related stimuli in the environment (Beck, 1976; Beck & Clark, 1997). Nevertheless, the wide range of empirical studies regarding threat-related biases in anxiety offer a somewhat confusing picture, plagued by contradictory findings that lack