Reappraisal of optimal hemoglobin standards for female blood donors in Canada

Pi, Dingan; Krikler, Samuel; Sparling, TG; Carter, C.J.; Wadsworth, L.E.

doi:10.1046/j.1537-2995.1994.34194098609.x

Cited by 12 publications

(8 citation statements)

References 14 publications

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“…Two studies in the past reported no significant difference between finger-stick sample and VS. 15 , 22 A large numbers of studies have subsequently reported an overestimation of Hb with capillary blood. 2 , 14 , 16 Mendrone et al 23 and Bahadur et al 24 have reported an overestimation of venous Hb values by capillary screening using HemoCue by ~7–8 g/L. Several plausible reasons have been suggested for this.…”

Section: Factors Affecting the Hb Test Resultsmentioning

confidence: 99%

Techniques used for the screening of hemoglobin levels in blood donors: current insights and future directions

Chaudhary¹,

Sonker²

2017

JBM

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Blood donor hemoglobin (Hb) estimation is an important donation test that is performed prior to blood donation. It serves the dual purpose of protecting the donors’ health against anemia and ensuring good quality of blood components, which has an implication on recipients’ health. Diverse cutoff criteria have been defined world over depending on population characteristics; however, no testing methodology and sample requirement have been specified for Hb screening. Besides the technique, there are several physiological and methodological factors that affect accuracy and reliability of Hb estimation. These include the anatomical source of blood sample, posture of the donor, timing of sample and several other biological factors. Qualitative copper sulfate gravimetric method has been the archaic time-tested method that is still used in resource-constrained settings. Portable hemoglobinometers are modern quantitative devices that have been further modified to reagent-free cuvettes. Furthermore, noninvasive spectrophotometry was introduced, mitigating pain to blood donor and eliminating risk of infection. Notwithstanding a tremendous evolution in terms of ease of operation, accuracy, mobility, rapidity and cost, a component of inherent variability persists, which may partly be attributed to pre-analytical variables. Hence, blood centers should pay due attention to validation of test methodology, competency of operating staff and regular proficiency testing of the outputs. In this article, we have reviewed various regulatory guidelines, described the variables that affect the measurements and compared the validated technologies for Hb screening of blood donors along with enumeration of their merits and limitations.

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Section: Factors Affecting the Hb Test Resultsmentioning

confidence: 99%

Techniques used for the screening of hemoglobin levels in blood donors: current insights and future directions

Chaudhary¹,

Sonker²

2017

JBM

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“…This result is in agreement with previous studies, which reported that finger stick samples may overestimate in hemoglobin measurements from Ϫ0.1 to ϩ0.4 g ⅐ dl Ϫ1 and that ear stick samples may differ from the hemoglobin concentration in a range of Ϫ0.7 to ϩ2.8 g ⅐ dl Ϫ1 . 17,[22][23][24][25] Using capillary blood samples to compare HemoCue ® and automated hemoglobin analysis, Van de Louw et al reported discrepancies of more than 1 g ⅐ dl Ϫ1 in 21% of cases and more than 2 g ⅐ dl Ϫ1 in 4% of cases. 26 In critically ill patients, Seguin et al 27 recently showed a poor agreement between laboratory hemoglobin measurement and HemoCue ® , especially with capillary blood samples and to a much greater extent for patients with edema.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 However, the accuracy of the HemoCue ® device is lower than that of CO-oximeters in the laboratory, and the variability is much more significant for capillary samples. 17,[22][23][24][25][26][27] In addition to these two invasive methods, SpHb monitoring is a new continuous noninvasive method of hemoglobin measurement based on spectrophotometry technology, still under improvement, for which the first validation studies were presented in 2007 by Macknet et al Although results from these authors and our studies seem to show good correlation between SpHb and hemoglobin laboratory measurement, our study clearly shows that SpHb is not equivalent to HemoCue ® for hemoglobin measurement, taking as reference the automated hemoglobin measurement in the laboratory (figs. 2 and 3).…”

Section: Sphb and Hemocue ® Compared With Laboratory Measurementmentioning

confidence: 99%

Comparison of the Accuracy of Noninvasive Hemoglobin Monitoring by Spectrophotometry (SpHb) and HemoCue® with Automated Laboratory Hemoglobin Measurement

Lamhaut¹,

Apriotesei

Combes³

et al. 2011

Anesthesiology

145

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“…The purpose of setting a minimal hemoglobin level is to exclude anemic donors from donation, thus protecting their health [31]. A study of repeat female donors in Canada found that 67% of donors with hemoglobin greater than 115 g/l were actually iron-deficient [39]. Research is needed to evaluate the prevalence of iron deficiency among Chinese female donors to help select the appropriate hemoglobin cut-off for donation for the protection of the donors.…”

Section: Donor Selectionmentioning

confidence: 99%

Blood Donor Management in China

Shi

Wang

Liu

et al. 2014

Transfus Med Hemother

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Despite a steady increase in total blood collections and voluntary non-remunerated blood donors, China continues to have many challenges with its blood donation system. The country's donation rate remains low at 9‰, with over 60% of donors being first-time donors. Generally there is a lack of adequate public awareness about blood donation. The conservative donor selection criteria, the relatively long donation interval, and the small donation volume have further limited blood supply. To ensure a sufficient and safe blood supply that meets the increasing clinical need for blood products, there is an urgent need to strengthen the country's blood donor management. This comprehensive effort should include educating and motivating more individuals especially from the rural areas to be involved in blood donation, developing rational and evidence-based selection criteria for donor eligibility, designing a donor follow-up mechanism to encourage more future donations, assessing the current donor testing strategy, improving donor service and care, building regional and national shared donor deferral database, and enhancing the transparency of the blood donation system to gain more trust from the general public. The purpose of the review is to provide an overview of the key process of and challenges with the blood donor management system in China.

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Reappraisal of optimal hemoglobin standards for female blood donors in Canada

Abstract: This study supports the use of a higher Hb cutoff value of 125 g per L for female blood donors in the predonation fingerstick copper sulfate test.

Cited by 12 publications

References 14 publications

Techniques used for the screening of hemoglobin levels in blood donors: current insights and future directions

Techniques used for the screening of hemoglobin levels in blood donors: current insights and future directions

Comparison of the Accuracy of Noninvasive Hemoglobin Monitoring by Spectrophotometry (SpHb) and HemoCue® with Automated Laboratory Hemoglobin Measurement

Blood Donor Management in China

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