Reappraisal of Solitary Bronchiolar (Alveolar Cell) Carcinoma of the Lung

Munnell, Edward R.; Dilling, Emery; Grantham, R. Nathan; Harkey, Michael R.; Mohr, John A.

doi:10.1016/s0003-4975(10)63543-6

Cited by 23 publications

(18 citation statements)

References 14 publications

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“…Historically, the term has been under much debate and different views have been presented to attest to its clinical behavior without, however, producing a unifying agreement. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] In 1960, Liebow 20 introduced the term bronchioloalveolar carcinoma to describe a well-differentiated adenocarcinoma that may have long dormancy or slow growth, particularly in those patients presenting with isolated nodules. More recently and exclusively looking at the solitary nodule pattern, there have been proposals for a change in the nomenclature of pulmonary adenocarcinomas with a pure lepidic or bronchioloalveolar growth pattern.…”

Section: Discussionmentioning

confidence: 99%

Early-stage pulmonary adenocarcinoma (T1N0M0): a clinical, radiological, surgical, and pathological correlation of 104 cases. The MD Anderson Cancer Center Experience

et al. 2013

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The recent proposal for histological subtyping of pulmonary adenocarcinoma by predominant pattern and introduction of the terms adenocarcinoma in situ and minimally invasive adenocarcinoma to replace the term bronchioloalveolar carcinoma by the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society has led us to conduct a study of 104 patients with early-stage primary pulmonary adenocarcinoma (T1N0M0), with a view to histological subtype as defined by the new proposal and clinical outcome. None of the clinical parameters of our patient population (type of surgery, age, gender, tumor size, and comorbidities) showed any statistically significant correlation with outcome, except for associated malignancies, which not surprisingly appeared to have a negative impact on survival. In addition, statistical analyses of the histological characteristics to include tumor differentiation and the percentage of a lepidic or bronchioloalveolar component did not show any statistically significant values in terms of survival. Our results failed to show any statistically significant difference of survival between those T1N0M0 adenocarcinomas with a lepidic component and those without, thus questioning the use of terms such as in situ or minimally invasive adenocarcinoma. On the basis of our results, we consider that the outcome for patients with T1N0M0 disease is still best determined by appropriate staging rather than by changes in the pathology nomenclature of adenocarcinoma. The number of deaths due to lung cancer among this group was approximately 158 thousand. Also according to SEER, the age group more commonly affected is individuals between the ages of 55 and 74 years, with a median age at diagnosis of 71 years. Although lung cancer is also seen in younger age groups, people under 45 years of age represent approximately 2% of the total number of cases, while those people between the ages of 45 and 54 years represent approximately 9% of the total number of cases. It is also suggested that factors such as smoking, dietary habits, family history, and chemical exposure to compounds such as asbestos, radon, and silica among many others may play a role in lung cancer pathogenesis. Of all the different types of lung cancer, adenocarcinoma is currently the most frequent.In an effort to better define clinical behavior regarding small size adenocarcinomas, various studies have used different ways to address this issue.

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Section: Discussionmentioning

confidence: 99%

Early-stage pulmonary adenocarcinoma (T1N0M0): a clinical, radiological, surgical, and pathological correlation of 104 cases. The MD Anderson Cancer Center Experience

et al. 2013

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“…Thus, prognosis differs markedly depending upon the radiological pattern. A nodule less than 3 cm in diameter may be cured by surgery in over 70% of patients [30][31][32][33], whereas death usually occurs in less than 3 yrs in the presence of diffuse disease [21]. A lobar consolidation has, theoretically, a somewhat better prognosis than does diffuse disease; however, experience with patients in this series agrees with the findings of EPSTEIN et al [3] and HILL [21], who have noted that the prognosis of BAC presenting as a localized area of consolidation is poor.…”

Section: Discussionmentioning

confidence: 99%

Bronchioloalveolar carcinoma: computed tomography findings

Trigaux¹,

Gevenois²,

Goncette³

et al. 1996

Eur Respir J

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“…Early reports propounding a multicentric origin [Storey et al, 1953, Delarue andGraham, 1949] appear to have been biased by observation of predominately faradvanced cases. Studies published during the 1960s began to question the concept of multicentric origin [Hawkins et al, 1963, Knudson et al, 1965, The re cent literature, including the large number of cases reported having solitary resectable lesions, decisively refutes this concept [Ludington et al, 1972, McNamara et al, 1969, Munnell et al, 1978.…”

Section: Discussionmentioning

confidence: 99%