Reappraisal of the drifting scenario of leprosy multi‐drug therapy: new approach proposed for the new millennium

Bhattacharya, Sambit; Sehgal, Virendra

doi:10.1046/j.1365-4362.2002.01506.x

Cited by 12 publications

(11 citation statements)

References 16 publications

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“…Oral involvement in this type of disease is rare and it may be related to the intense response of the host’s immune system and little number of organisms in this type of disease (8). This finding is in disagreement with de Abreu et al (25).…”

Section: Discussionmentioning

confidence: 99%

“…The main clinical features of leprosy are listed as follows: erythematous or hypopigmented macules on the skin with reduced sensation, distinct sensory loss and peripheral nerve involvements, muscle weakness, nerve thickening, positive skin biopsy of acid – fast bacilli and positive skin smear. It is noted that a subject with one or two of these major findings should be considered as a leprosy case (8). …”

Section: Introductionmentioning

confidence: 99%

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Oro-facial manifestations of 100 leprosy patients

Taheri¹,

Mortazavi²,

Moshfeghi³

et al. 2012

Med Oral

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Objectives: To verify the frequency of oral and facial involvement in diagnosed leprosy patients. Study design: This study was performed on 100 leprosy patients (62 male, 38 female, mean ages 51.86±6.1). After explaining the study design, we studied descriptive information including: patient’s sex, age, job, place of birth, familial history of leprosy, types of disease (lepromatous, borderline and tuberculoid leprosy), ocular and oral lesions, facial involvement and neuropathy. The statistical signification was measured by chi-square test. Results: A total of 46 (23 lepromatous, 15 borderline, and 8 tuberculoid leproy) out of 100 patients with leprosy had oral lesions. Statistical analysis did not show any significant difference in frequency of oral lesions between different types of disease. Facial lesions were presented in 57 (39 lepromatous, 10 borderline, and 8 tuberculoid leprosy) patients. There was a statistical significant difference in frequency of facial manifestations between different types of leprosy. It has to be mentioned that, atrophy of nasal spine, facial nerve involvement, ocular lesions and facial deformity were seen in 15%, 17%, 22% and 44% of leprosy patients, respectively. Conclusion: Examination of leprosy patients should be extended to the oral mucosa because oral mucosa may be a secondary source of M.Leprae transmission and infection. Key words:Leprosy, lepromatous, tuberculoid, oral lesions, facial lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oro-facial manifestations of 100 leprosy patients

Taheri¹,

Mortazavi²,

Moshfeghi³

et al. 2012

Med Oral

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“…It may be because of the very slow proliferation of the bacilli or the prolonged incubation period, or perhaps a particular cellular mechanism involved in its pathogenesis. [24][25][26] In 1981, the WHO Study Group recommended multiple drug therapy (MDT) for the following reasons: 24 1. To address dapsone resistance and to discourage resistance to other drugs to be used.…”

Section: Hansen's Disease and Pregnancy 2021mentioning

confidence: 99%

“…In 1997, the WHO Expert Committee suggested that it might be possible to reduce duration of MDT for multibacillary disease from 2 years to one year and also recommended the treatment of a single PB lesion with one dose of ROM (rifampin, ofloxacin, and minocycline). 26 The current WHO recommended MDT for adults is as follows:…”

Section: Hansen's Disease and Pregnancy 2021mentioning

confidence: 99%

An update on the diagnosis and treatment of leprosy

Moschella

2004

Journal of the American Academy of Dermatology

143

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“…The MDT, as recommended by Word Healthy Organization (WHO), consisted of rifampicin and dapsone for paucibacillary patients and rifampicin, dapsone and clofazimine for the multibacillary ones. 23 The episodes of reaction were treated with corticosteroids and/or thalidomide.…”

Section: Patientsmentioning

confidence: 99%

It is time to review concepts on renal involvement in leprosy: pre- and post-treatment evaluation of 189 patients

et al. 2015

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Background: Functional and morphological renal lesions have been widely described in leprosy for decades. Nevertheless few studies have assessed renal function pre-and during treatment after the advent of multidrug therapy (MDT). Methods: This is a prospective study involving 189 consecutive patients, with all forms of leprosy (Ridley-Jopling scale). Laboratory (serum urea and creatinine, estimated GFR, urinalysis, microalbuminuria, urinary RBP) and clinical features of renal disease were evaluated previously and after onset (3 and 8 months later) of MDT. Results: One hundred and eighty-nine patients (M 1.8: F 1; mean age 44 ± 16 years) were included just after diagnosis of leprosy and before the introduction of MDT. Mean time until manifestation of symptoms and/or signs of leprosy was 29 ± 56 months (25 days-480 months). Microhematuria and microalbuminuria were detected in 7.5% and 9.6% of the cases, respectively. Elevated serum creatinine was detected in 34% pre-MDT; this was statistically more frequent in males, hypertensive and frequent users of non-steroidal anti-inflammatory drugs (NSAID), as well as in patients with erythema nodosum lepromatosum, 45.5% by the time of diagnosis, 18% after 3 months and 9% after 8 months of MDT (p ¼ 0.039). Conclusions: Our results suggest that functional renal lesions in leprosy are currently mild and predominantly of glomerular origin, in opposition to the severe involvement described in the past. This improved outcome of renal disease secondary to leprosy is possibly due to the advent of MDT and effective treatment of episodes of reaction, leading to shorter periods of active infectious disease.

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Reappraisal of the drifting scenario of leprosy multi‐drug therapy: new approach proposed for the new millennium

Cited by 12 publications

References 16 publications

Oro-facial manifestations of 100 leprosy patients

Oro-facial manifestations of 100 leprosy patients

An update on the diagnosis and treatment of leprosy

It is time to review concepts on renal involvement in leprosy: pre- and post-treatment evaluation of 189 patients

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