Reappraisal of XRCC1 Arg194Trp polymorphism and glioma risk: a cumulative meta-analysis

Abstract

The association between XRCC1 Arg194Trp polymorphism and glioma risk were inconsistent from published meta-analyses and epidemiological studies. Hence, we performed this updated and cumulative meta-analysis to reappraisal this relationship. PubMed, Embase, CBM (Chinese Biomedical Database), and CNKI (China National Knowledge Internet) databases were comprehensively searched up to August 13, 2016 (updated on December 22, 2016). After study selection and data extraction from eligible studies, the association was evaluated by odds ratios (ORs) and its 95% confidence intervals (95%CIs) using Comprehensive Meta-Analysis software. Finally 16 case-control studies involving 7011 patients and 9519 healthy controls were yielded. The results indicated that XRCC1 Arg194Trp polymorphism was significantly correlated with the increased risk of glioma [Trp vs. Arg: OR = 1.18(1.05-1.34); TrpTrp vs. ArgArg: OR = 1.66(1.31-2.12); ArgTrp vs. ArgArg: OR = 1.34(1.02-1.77); TrpTrp vs. ArgArg+ArgTrp: OR = 1.47(1.26-1.72); TrpTrp+ArgTrp vs. ArgArg: OR = 1.17(1.01-1.35)]. Cumulative analysis showed the results changed from non-significant to significant when new studies accumulated, and sensitivity analysis indicated the results were stable. Subgroup analysis showed the significant association existed in Asians but not in Caucasians. Current evidence indicated that XRCC1 Arg194Trp polymorphism was associated with increased risk for glioma, especially in Asians; however, relevant studies involving other ethnic groups are required to validate our findings in further.

Association of XRCC1 rs1799782 and ERCC2 rs13181 Polymorphisms with Glioma Risk: A Systematic Review and Meta-Analysis

“…Custodio et al [20] reported an increased risk for gliomas in Caucasians with the XRCC1 rs1799782 SNP (Brazilian population), but they also observed improved survival in the presence of the 194Trp allele. Finally, in the study published by Fan et al [8] there was an increased risk for gliomas in participants that had TT or CT + TT genotypes (Table 2) [14][15][16][17][18][19][20][21][22][23][24].…”

“…Lu et al [24] reviewed sixteen published papers and reported increased risk only for Asians with TT and TT + CT genotype in their meta-analysis. Xu et al [25] found an increased risk only in Asians with CT + TT genotype and in both Asians and Caucasians with TT genotype.…”

A meta-analysis of the association between poultry and egg consumption and the risk of brain cancer

“…Furthermore, glioma accounts for about 50% of primary tumors of the central nervous system (4,5). Epidemiology studies have indicated that genetic factor is an established risk factor for brain cancer patients (6,7). Furthermore, external environment, such as long-term mobile phone use (8) could increase the risk of glioma.…”

XRCC1 rs1799782 polymorphism and objective response rate in NSCLC patients treated with platinum-based chemotherapy

“…Evidence has shown that polymorphisms in DNA repair genes could influence individual DNA repair capacity [4]. Lu et al suggested that XRCC1 Arg194Trp polymorphism was associated with increased risk for glioma, especially in Asians [5]. Yang et al indicated that no association between rs25487 or rs1799782 gene polymorphism and risk of female reproductive cancer risk was found [6].…”