Reappraising 21 years of the WHI study: Putting the findings in context for clinical practice

Stute, Petra; Marsden, Jo; Salih, N.; Cagnacci, Angelo

doi:10.1016/j.maturitas.2023.04.271

Cited by 10 publications

(6 citation statements)

References 53 publications

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“…HT shows a more favorable risk-benefit ratio when started in the early stages of menopause. In addition, the symptomatic benefits of HT seem to outweigh the risks of side effects when the therapy is used for up to five years (Stute et al, 2023). HT is recommended as the most effective treatment for menopausal symptoms, including sleep disorders (Cintron et al, 2017).…”

Section: Efficacy Of Hormone Replacement Therapy On Sleep In Postmeno...mentioning

confidence: 99%

The impact of postmenopause on sleep and sleep disorders: The current state of the art

Silva,

Lima,

Maldonado

et al. 2023

RSD

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Sleep disorders in postmenopausal women are important symptoms that demonstrate the impact of the hormonal changes that have begun since menopause. Hormonal changes during the transition to postmenopause play a crucial role in sleep disorders, contributing to symptoms such as insomnia, hot flashes, obstructive sleep apnea and restless legs syndrome. Such disorders impact on women's quality of life, increasing the risks of developing chronic and psychological health conditions, including depression, anxiety and cardiovascular disease. In addition, Hormone Replacement Therapy (HRT) in the treatment of menopausal symptoms is the most widely used pharmacological therapy, although its effectiveness in improving sleep quality is still uncertain due to the heterogeneous nature of the results. Sleep hygiene, together with Cognitive-Behavioral Therapy for Insomnia (CBT), has emerged as a promising non-pharmacological approach to the management of sleep disorders in postmenopausal women. The management of sleep disorders in postmenopausal women should be analyzed taking into account the physical, psychological and hormonal aspects of the patients.

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Section: Efficacy Of Hormone Replacement Therapy On Sleep In Postmeno...mentioning

confidence: 99%

The impact of postmenopause on sleep and sleep disorders: The current state of the art

Silva,

Lima,

Maldonado

et al. 2023

RSD

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“…In fact, the enrolled women were asymptomatic, on average older than 60 years old, and frequently more than 10 years after the onset of menopause. These results struck the medical community, causing widespread distrust in HRT, with a dramatic drop in its prescription in the following years [14].…”

Section: Introductionmentioning

confidence: 99%

“…The most prominent medical societies published numerous guidelines on the proper use and prescription of HRT, focusing mainly on adequate patient selection and route of administration. Apparently, this effort was not enough to settle the confusion among both health professionals and patients on the indications for HRT: a diffuse distrust and many uncertainties appear to persist among physicians [4,14,17].…”

Section: Introductionmentioning

confidence: 99%

Menopausal Hormone Therapy, an Ever-Present Topic: A Pilot Survey about Women’s Experience and Medical Doctors’ Approach

Aquino,

Stampini,

Osella

et al. 2024

Medicina

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Background and Objective: Menopause can be associated with many clinical manifestations: vasomotor symptoms, urogenital problems, and additional psychological disturbances, such as anxiety, mood changes, and sleep alterations. The prolonged lack of hormones also increases the risk of long-term consequences. Hormone Replacement Treatment (HRT) in menopause consists of the administration of estrogen, alone or associated to progesterone, to relieve these uncomfortable disturbances and to prevent the onset of other pathologic conditions. The aim of this study is to examine the prevalence of HRT use in a sample of menopausal women and their experience with menopause and HRT. This study also investigates the knowledge of general practitioners (GPs) and gynecologists about HRT and its prescription. Materials and Methods: We conducted a cross-sectional population survey on 126 women of 50–59 years in an industrial city in the North of Italy, Vercelli (Novara), in Eastern Piedmont. We also presented a questionnaire on the topic to 54 medical doctors (GPs and gynecologists) of the same area. Results: The prevalence of HRT use in our sample was 11.9%. In total, a good percentage of the users affirmed to be satisfied with HRT. Additionally, a minority of women reported being ideally against the use of replacement hormones, were advised against using HRT by doctors, and did not use it because of the fear of side effects. We found a positive association between patient education, health care attitude, and HRT usage. A significant number of women knew about HRT from the media, and most of them were not informed by a health professional. Despite this, the interviewed doctors considered their knowledge about HRT as ‘good’ and would recommend HRT: only 5.6% would not prescribe it. Conclusions: Our results highlight the need for information about HRT among patients and health professionals, along with the need for more effective communication, evaluation, and suggestion of treatment.

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“…Most notably, maca has been colloquially referred to as “Peruvian Viagra” as a substitute for medications typically used for erectile dysfunction, like sildenafil and tadalafil [ 8 , 53 , 54 ]. In addition to sexual health, the interest in maca as a viable alternative to medications has been more extensively explored for benign prostatic hyperplasia (BPH) and menopausal symptoms due to potential contraindications or side effects that can occur with drugs like finasteride [ 55 , 56 , 57 ] or even hormone replacement therapy (HRT) [ 58 ]. Some women have explored maca as another option or even in conjunction with in vitro fertilization (IVF).…”

Section: Introductionmentioning

confidence: 99%

Not All Maca Is Created Equal: A Review of Colors, Nutrition, Phytochemicals, and Clinical Uses

Minich,

Ross,

Frame

et al. 2024

Nutrients

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Maca (Lepidium meyenii, Lepidium peruvianum) is part of the Brassicaceae family and grows at high altitudes in the Peruvian Andes mountain range (3500–5000 m). Historically, it has been used as a nutrient-dense food and for its medicinal properties, primarily in enhancing energy and fertility. Scientific research has validated these traditional uses and other clinical applications by elucidating maca’s mechanisms of action, nutrition, and phytochemical content. However, research over the last twenty years has identified up to seventeen different colors (phenotypes) of maca. The color, hypocotyl size, growing location, cultivation, and post-harvest processing methods can have a significant effect on the nutrition content, phytochemical profile, and clinical application. Yet, research differentiating the colors of maca and clinical applications remains limited. In this review, research on the nutrition, phytochemicals, and various colors of maca, including black, red, yellow (predominant colors), purple, gray (lesser-known colors), and any combination of colors, including proprietary formulations, will be discussed based on available preclinical and clinical trials. The gaps, deficiencies, and conflicts in the studies will be detailed, along with quality, safety, and efficacy criteria, highlighting the need for future research to specify all these factors of the maca used in publications.

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Reappraising 21 years of the WHI study: Putting the findings in context for clinical practice

Cited by 10 publications

References 53 publications

The impact of postmenopause on sleep and sleep disorders: The current state of the art

The impact of postmenopause on sleep and sleep disorders: The current state of the art

Menopausal Hormone Therapy, an Ever-Present Topic: A Pilot Survey about Women’s Experience and Medical Doctors’ Approach

Not All Maca Is Created Equal: A Review of Colors, Nutrition, Phytochemicals, and Clinical Uses

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