Rearing conditions differently affect the motor performance and cerebellar morphology of prenatally stressed juvenile rats

Ulupinar, Emel; Erol, Kevser; Ay, Hakan; Yücel, Ferruh

doi:10.1016/j.bbr.2014.10.003

Cited by 9 publications

(13 citation statements)

References 74 publications

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“…Our results indicate that the IS group did not show an impairment in motor coordination or resistance to fatigue. To our knowledge, only one previous study used the rorarod test in isolated animals to test motor skills [46]. Their isolation procedure took place post-weaning, and they found worse performance.…”

Section: Discussionmentioning

confidence: 95%

Adult social isolation leads to anxiety and spatial memory impairment: Brain activity pattern of COx and c-Fos

Zorzo

Méndez-López

Méndez

et al. 2019

Behavioural Brain Research

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Social isolation during adulthood is a frequent problem that leads to a large variety of adverse emotional and cognitive effects. However, most of the social isolation rodent procedures begin the separation early post-weaning. This work explores locomotor activity, anxiety-like behaviour, and spatial working memory after twelve weeks of adult social isolation. In order to study the functional contribution of selected brain areas following a working memory task, we assessed neuronal metabolic activity through quantitative cytochrome oxidase histochemistry and c-Fos immunohistochemistry. Behaviourally, we found that isolated animals (IS) showed anxiety-like behaviour and worse working memory than controls, whereas motor functions were preserved. Moreover, IS rats showed lower levels of learning-related c-Fos immunoreactivity, compared to controls, in the medial prefrontal cortex (mPFC), ventral tegmental area (VTA), and nucleus accumbens shell. In addition, the IS group showed lower neuronal metabolic activity in the mPFC, VTA, and CA1 subfield of the hippocampus. These results indicate that twelve weeks of social isolation in adult rats leads to different behavioural and brain alterations, and they highlight the importance of social support, not only in development, but also in adulthood.

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Section: Discussionmentioning

confidence: 95%

Adult social isolation leads to anxiety and spatial memory impairment: Brain activity pattern of COx and c-Fos

Zorzo

Méndez-López

Méndez

et al. 2019

Behavioural Brain Research

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“…Diverse rearing conditions also can alter the motor skills of animals and synaptic connectivity of the cerebellar neurons in a gender-dependent manner (Ulupinar and Yucel, 2005;Ulupinar et al, 2006Ulupinar et al, , 2014. While effective stress management strategies, such as environmental enrichment, induce structural spine plasticity, maternal separation or early postweaning social isolation reduces the dendritic arbors of neurons located in the cerebellum, hippocampus and limbic circuitry (Murmu et al, 2006;Ferdman et al, 2007;Bock et al, 2011;Gonzalez-Burgos et al, 2011;Mychasiuk et al, 2012;Pascual, 2013).…”

Section: Introductionmentioning

confidence: 95%

Gender- and anxiety level-dependent effects of perinatal stress exposure on medial prefrontal cortex

Soztutar

Çolak

Ulupinar

2016

Experimental Neurology

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“…Behavioural tests for motor skills in PS- and EE-treated animals included the rotarod (balancing on a rotating rod), string suspension and skilled reaching tasks. PS animals across all studies showed superior performances in motor learning tasks [ 48 , 58 ]. EE however, showed differing effects, with one study showing a negative effect in motor learning tasks and reaching performance [ 58 ], and the other showing superior performance in motor tasks [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

“…PS animals across all studies showed superior performances in motor learning tasks [ 48 , 58 ]. EE however, showed differing effects, with one study showing a negative effect in motor learning tasks and reaching performance [ 58 ], and the other showing superior performance in motor tasks [ 48 ]. The major differences between these two studies were the duration of stress (G13–15 versus G14–21) and the type of stressor, one using restraint and the other using a combination of restraint, swim and mirror strength (see Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Environmental enrichment as an intervention for adverse health outcomes of prenatal stress

McCreary

Metz

2016

Environ Epigenet

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Prenatal stress (PS) has complex neurological, behavioural and physiological consequences for the developing offspring. The phenotype linked to PS usually lasts into adulthood and may even propagate to subsequent generations. The often uncontrollable exposure to maternal stress and the lasting consequences emphasize the urgent need for treatment strategies that effectively reverse stress programming. Exposure to complex beneficial experiences, such as environmental enrichment (EE), is one of the most powerful therapies to promote neuroplasticity and behavioural performance at any time in life. A small number of studies have previously used EE to postnatally treat consequences of PS in the attempt to reverse deficits that were primarily induced in utero . This review discusses the available data on postnatal EE exposure in prenatally stressed individuals. The goal is to determine if EE is a suitable treatment option that reverses adverse consequences of stress programming and enhances stress resiliency. Moreover, this review discusses data with respect to relevant hypotheses including the cumulative stress and the mismatch hypotheses. The articles included in this review emphasize that EE reverses most behavioural, physiological and neural deficits associated with PS. Differing responses may be dependent on the timing and variability of stress and EE, exercise, and potentially vulnerable and resilient phenotypes of PS. Results from this study suggest that enrichment may provide an effective therapy for clinical populations suffering from the effects of PS or early life trauma.

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Rearing conditions differently affect the motor performance and cerebellar morphology of prenatally stressed juvenile rats

Cited by 9 publications

References 74 publications

Adult social isolation leads to anxiety and spatial memory impairment: Brain activity pattern of COx and c-Fos

Adult social isolation leads to anxiety and spatial memory impairment: Brain activity pattern of COx and c-Fos

Gender- and anxiety level-dependent effects of perinatal stress exposure on medial prefrontal cortex

Environmental enrichment as an intervention for adverse health outcomes of prenatal stress

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