Rearranged Cycloartanol Glycosides from Sutherlandia frutescens

Fu, Xiaofang; Li, XC; Smillie, TJ; Khan, IA

doi:10.1055/s-0030-1251809

Cited by 9 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, sutherlandioside D had the strongest inhibition of Gli‐reporter activity among the fractions (Supplementary Figure S2). It has been reported that four cycloartane glycosides, sutherlandiosides A–D, are present in commercial S. frutescens material, as is SU1, the major triterpenoid (Fu et al, ; Van Wyk and Albrecht, ). Furthermore, major triterpenoids of S. frutescens are structurally related to cycloartane‐type tritepenoids, which have cancer chemopreventive activity (Kikuchi et al, ).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Gli/hedgehog signaling in prostate cancer cells by “cancer bush” Sutherlandia frutescens extract

Lin

Jackson

et al. 2015

Cell Biology International

View full text Add to dashboard Cite

Sutherlandia frutescens is a medicinal plant traditionally used to treat various types of human diseases, including cancer. Previous studies of several botanicals link suppression of prostate cancer growth with inhibition of the Gli/hedgehog (Gli/Hh) signaling pathway. Here we hypothesized the anti-cancer effect of S. frutescens was linked to its inhibition of the Gli/Hh signaling in prostate cancer. We found a dose- and time- dependent growth inhibition in human prostate cancer cells PC3 and LNCaP, and mouse prostate cancer cells TRAMP-C2 treated with S. frutescens methanol extract (SLE). We also observed a dose-dependent inhibition of the Gli-reporter activity in Shh Light II and TRAMP-C2QGli cells treated with SLE. In addition, SLE can inhibit Gli/Hh signaling by blocking Gli1 and Ptched1 gene expression in the presence of a Gli/Hh signaling agonist (SAG). A diet supplemented with S. frutescens suppressed the formation of poorly differentiated carcinoma in prostates of TRAMP mice. Finally, we found Sutherlandioside D was the most potent compound in the crude extract that could suppress Gli-reporter in Shh Light II cells. Together this suggests that the S. frutescens extract may exert anti-cancer effect by targeting Gli/Hh signaling, and Sutherlandioside D is one of the active compounds.

show abstract

Section: Discussionmentioning

confidence: 99%

Inhibition of Gli/hedgehog signaling in prostate cancer cells by “cancer bush” Sutherlandia frutescens extract

Lin

Jackson

et al. 2015

Cell Biology International

View full text Add to dashboard Cite

show abstract

“…The presence of the individual or combined sutherlandiosides and sutherlandins in the triterpenoid and flavonol glycoside fractions, as well as the aqueous and methanolic extracts of SF suggest that these phytochemical constituents of SF (24,25) may have contributed at least in part to any effects on the amount of ATV present after co-treatment of Caco-2 cells and human liver microsomes with ATV and each fraction and/or extract. The accumulation of ATV by Caco-2 cells may have been curtailed by the aqueous extract of SF by reducing the activity of influx transporters of ATV or enhancing the activity of efflux transporters of ATV, such as P-gp, which are present in Caco-2 cells and in the human intestinal epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…Prior to the isolation (24,25) and thus availability of sutherlandiosides and sutherlandins present in SF plant material, crude flavonol and triterpenoid glycoside fractions were prepared for use as indicators of the presence of flavonol and triterpenoid glycosides in SF plant material and extracts thereof.…”

Section: Preparation Of Sf Flavonol Glycoside and Triterpenoid Glycosmentioning

confidence: 99%

Interactions between Phytochemical Components of Sutherlandia Frutescens and the Antiretroviral, Atazanavir In Vitro: Implications for Absorption and Metabolism

et al. 2012

View full text Add to dashboard Cite

-Purpose. African traditional medicinal plants, such as Sutherlandia frutescens have the potential to interact pharmacokinetically with the protease inhibitor class of antiretrovirals, thereby impacting on their safety and efficacy. The effects of extracts and phytochemical components of Sutherlandia frutescens, on the in vitro absorption and metabolism of the protease inhibitor, atazanavir were thus investigated. Methods. Aqueous and methanolic extracts of Sutherlandia frutescens were prepared by freeze-drying of hot water and methanol decoctions of Sutherlandia frutescens plant material respectively, whilst crude triterpenoid glycoside and flavonol glycoside fractions were isolated by solvent extraction and subsequent column chromatography. Atazanavir was quantitated in the absence or presence of these compounds as well as commercially available purported constituents of Sutherlandia frutescens, namely, Lcanavanine, L-GABA and D-pinitol, after a one hour co-incubation in Caco-2 cell monolayers and human liver microsomes. Results. The triterpenoid and flavonol glycoside fractions were found to be present in the aqueous and methanolic extracts of Sutherlandia frutescens and were shown to contain the sutherlandiosides and sutherlandins known to be present in Sutherlandia frutescens. The aqueous extract and D-pinitol significantly reduced atazanavir accumulation by Caco-2 cells, implying a decrease in atazanavir absorption, whilst the opposite was true for the triterpenoid glycoside fraction. Both the aqueous and methanolic extracts inhibited atazanavir metabolism in human liver microsomes, whilst enhanced atazanavir metabolism was exhibited by the triterpenoid glycoside fraction. Conclusions. The extracts and phytochemical components of Sutherlandia frutescens influenced the accumulation of atazanavir by Caco-2 cells and also affected ATV metabolism in human liver microsomes. These interactions may have important implications on the absorption and metabolism and thus the overall oral bioavailability of atazanavir.

show abstract

“…Flavonoid glycosides have been discovered and isolated from the plant as potential actives and possible quality control markers [4,5]. Much of the biological effects of herbal medicinal remedies have been attributed to the presence of flavonoids [6,7], which are known to exist in this plant in glycosidic and aglycone forms.…”

Section: Introductionmentioning

confidence: 99%

The Potential for Climate Impacts from Widespread Deployment of Utility-Scale Solar Energy Installations: An Environmental Remote Sensing Perspective

Li¹,

Weigand²

2017

J Remote Sensing & GIS

View full text Add to dashboard Cite

Rearranged Cycloartanol Glycosides from Sutherlandia frutescens

Cited by 9 publications

References 0 publications

Inhibition of Gli/hedgehog signaling in prostate cancer cells by “cancer bush” Sutherlandia frutescens extract

Inhibition of Gli/hedgehog signaling in prostate cancer cells by “cancer bush” Sutherlandia frutescens extract

Interactions between Phytochemical Components of Sutherlandia Frutescens and the Antiretroviral, Atazanavir In Vitro: Implications for Absorption and Metabolism

The Potential for Climate Impacts from Widespread Deployment of Utility-Scale Solar Energy Installations: An Environmental Remote Sensing Perspective

Contact Info

Product

Resources

About