A basic version of the Pólya-Szegő inequality states that if Φ is a Young function, the Φ-Dirichlet energy-the integral of Φ( ∇f )-of a suitable function f ∈ V(R n ), the class of nonnegative measurable functions on R n that vanish at infinity, does not increase under symmetric decreasing rearrangement. This fact, along with variants that apply to polarizations and to Steiner and certain other rearrangements, has numerous applications. Very general versions of the inequality are proved that hold for all smoothing rearrangements, those that do not increase the modulus of continuity of functions. The results cover all the main classes of functions previously considered:In addition, anisotropic versions of these results, in which the role of the unit ball is played by a convex body containing the origin in its interior, are established. Taken together, the results bring together all the basic versions of the Pólya-Szegő inequality previously available under a common and very general framework.