Rearrangement of human T cell receptor β and γ chain genes in adult t cell leukemia/lymphoma

Ohshima, Koichi; Yoshida, Takashi; Kikuchi, Masahiro; Y, Masuda; Kimura, N.; Satoh, Hironobu

doi:10.1002/hon.2900080207

Cited by 9 publications

(3 citation statements)

References 25 publications

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“…HTLV-1 provirus integration was confirmed in all ATLL samples by ELISA and Southern-blot techniques. 18,19 For comparison, we studied a large series of samples representing T-and B-cell neoplasms, including T-cell lymphoblastic lymphoma (four), peripheral T-cell lymphoma (20), angioimmunoblastic T-cell lymphoma (five), T-cell/natural killer cell lymphoma (five), anaplastic large cell lymphoma (nine), mycosis fungoides (15), B-cell lymphocytic leukaemia/lymphoma (14), mantle cell lymphoma (14), marginal zone B-cell lymphoma (12), diffuse large B-cell lymphoma (17), follicular lymphoma (17) and Burkitt's lymphoma (15). Informed consent was obtained from all patients included in the study under the supervision of the local ethical committees.…”

Section: Patient Samplesmentioning

confidence: 99%

FOXP3, a selective marker for a subset of adult T-cell leukaemia/lymphoma

et al. 2005

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Section: Patient Samplesmentioning

confidence: 99%

FOXP3, a selective marker for a subset of adult T-cell leukaemia/lymphoma

et al. 2005

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“…, 1997). TCR genes are clonally rearranged (Ohshima et al. , 1990) and the demonstration of a clonal population of T cells in the peripheral blood of healthy HTLV‐1 carriers may identify patients at risk of developing ATLL (Sales et al.…”

Section: Adult T Cell Leukaemia/lymphomamentioning

confidence: 99%

Molecular genetic analysis of haematological malignancies II: mature lymphoid neoplasms

Bench

Erber

Follows

et al. 2007

Int J Lab Hematology

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Summary Molecular genetic techniques have become an integral part of the diagnostic assessment for many lymphomas and other chronic lymphoid neoplasms. The demonstration of a clonal immunoglobulin or T cell receptor gene rearrangement offers a useful diagnostic tool in cases where the diagnosis is equivocal. Molecular genetic detection of other genomic rearrangements may not only assist with the diagnosis but can also provide important prognostic information. Many of these rearrangements can act as molecular markers for the detection of low levels of residual disease. In this review, we discuss the applications of molecular genetic analysis to the chronic lymphoid malignancies. The review concentrates on those disorders for which molecular genetic analysis can offer diagnostic and/or prognostic information.

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“…ATL has four clinical subtypes including acute, lymphoma, chronic, and smoldering subtypes, and its prognosis remain poor, especially in aggressive typed ATL (acute and lymphoma type) due to rapid progression ( 11 ). ATL is characterized by clonal proliferation of CD4 + T cells containing integrated HTLV-1 provirus, typically associated with T cell receptor (TCR) gene rearrangements ( 12 , 13 ). The malignant T cells have lobulated nuclei (“flower cells”) with condensed chromatin and express characteristic T cell markers, CD3 + , CD4 + , CD5 + , CD7 - , CD25 + , CD26 - , and a monoclonal TCRVβ ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

T cell receptor repertoire analysis in HTLV-1-associated diseases

2022

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Human T lymphotropic virus 1 (HTLV-1) is a human retrovirus identified as the causative agent in adult T-cell leukemia/lymphoma (ATL) and chronic-progressive neuroinflammatory disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 is estimated to infect between 5-20 million people worldwide, although most infected individuals remain asymptomatic. HTLV-1 infected persons carry an estimated lifetime risk of approximately 5% of developing ATL, and between 0.25% and 1.8% of developing HAM/TSP. Most HTLV-1 infection is detected in CD4+T cellsin vivowhich causes the aggressive malignancy in ATL. In HAM/TSP, the increase of HTLV-1 provirus induces immune dysregulation to alter inflammatory milieu, such as expansion of HTLV-1-specific CD8+T cells, in the central nervous system of the infected subjects, which have been suggested to underlie the pathogenesis of HAM/TSP. Factors contributing to the conversion from asymptomatic carrier to disease state remain poorly understood. As such, the identification and tracking of HTLV-1-specific T cell biomarkers that may be used to monitor the progression from primary infection to immune dysfunction and disease are of great interest. T cell receptor (TCR) repertoires have been extensively investigated as a mechanism of monitoring adaptive T cell immune response to viruses and tumors. Breakthrough technologies such as single-cell RNA sequencing have increased the specificity with which T cell clones may be characterized and continue to improve our understanding of TCR signatures in viral infection, cancer, and associated treatments. In HTLV-1-associated disease, sequencing of TCR repertoires has been used to reveal repertoire patterns, diversity, and clonal expansions of HTLV-1-specific T cells capable of immune evasion and dysregulation in ATL as well as in HAM/TSP. Conserved sequence analysis has further been used to identify CDR3 motif sequences and exploit disease- or patient-specificity and commonality in HTLV-1-associated disease. In this article we review current research on TCR repertoires and HTLV-1-specific clonotypes in HTLV-1-associated diseases ATL and HAM/TSP and discuss the implications of TCR clonal expansions on HTLV-1-associated disease course and treatments.

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Rearrangement of human T cell receptor β and γ chain genes in adult t cell leukemia/lymphoma

Cited by 9 publications

References 25 publications

FOXP3, a selective marker for a subset of adult T-cell leukaemia/lymphoma

FOXP3, a selective marker for a subset of adult T-cell leukaemia/lymphoma

Molecular genetic analysis of haematological malignancies II: mature lymphoid neoplasms

T cell receptor repertoire analysis in HTLV-1-associated diseases

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