Rearrangement Reactions for the Synthesis of Some Oxa- and Aza-tricyclic Rings Heterocyclic Compounds

Abstract

This review article describes the main results of our research during the last 5-6 years. A series of new rearrangement reactions was discovered and used for the synthesis of novel

Organo-Catalyzed Asymmetric Michael–Hemiketalization–Oxa-Pictet–Spengler Cyclization for Bridged and Spiro Heterocyclic Skeletons: Oxocarbenium Ion as a Key Intermediate

“…Among them, the synthesis of bridged or spiro heterocycles that possess all quaternary carbon centers is always a challenging research area . It has been primarily addressed by nucleophilic addition, photoinduced electron transfer, intramolecular Baylis–Hillman reaction, Diels–Alder reaction, cycloadditions and condensations, rearrangement, dearomatization, as well as multicomponent and domino reactions . Despite the myriad approaches afforded by these reactions, few synthetic methods that produce bridged and spiro heterocycles structures were developed by using acyclic precursors.…”