Reasons for discard of umbilical cord blood units before cryopreservation

Lecchi, Lucilla; Ratti, Ilaria; Lazzari, Lorenza; Rebulla, Paolo; Sirchia, G.

doi:10.1046/j.1537-2995.2000.40010122.x

Cited by 26 publications

(28 citation statements)

References 7 publications

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“…Of these, only 8,750 units (50%) met eligibility criteria, were HLAtyped and entered into the search registry. Other authors report high deferral rates as well: Lecchi et al [14] with Italian data, Stanworth et al [15] in an international and Troeger et al in a Swiss survey [16], ranging from 20 to 90%.…”

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confidence: 90%

“…Further analysis was conducted on whether current CB banking practices were economically viable given the units being selected from the registries for transplant. It should be mentioned that our analysis Transfus Med Hemother 2013;40: [14][15][16][17][18][19][20] Impact of Selection of Cord Blood Units on the Cost of Banking Operations…”

Section: Introductionmentioning

confidence: 99%

“…Transfus Med Hemother 2013;40: [14][15][16][17][18][19][20] Bart/Boo/Balabanova/Fischer/Nicoloso/ Foeken/Oudshoorn/Passweg/Tichelli/Kindler/ Kurtzberg/Price/Regan/Shpall/Schwabe…”

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confidence: 99%

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Impact of Selection of Cord Blood Units from the United States and Swiss Registries on the Cost of Banking Operations

Bart

Boo

Balabanova

et al. 2013

Transfus Med Hemother

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Background: Over the last 2 decades, cord blood (CB) has become an important source of blood stem cells. Clinical experience has shown that CB is a viable source for blood stem cells in the field of unrelated hematopoietic blood stem cell transplantation. Methods: Studies of CB units (CBUs) stored and ordered from the US (National Marrow Donor Program (NMDP) and Swiss (Swiss Blood Stem Cells (SBSC)) CB registries were conducted to assess whether these CBUs met the needs of transplantation patients, as evidenced by units being selected for transplantation. These data were compared to international banking and selection data (Bone Marrow Donors Worldwide (BMDW), World Marrow Donor Association (WMDA)). Further analysis was conducted on whether current CB banking practices were economically viable given the units being selected from the registries for transplant. It should be mentioned that our analysis focused on usage, deliberately omitting any information about clinical outcomes of CB transplantation. Results: A disproportionate number of units with high total nucleated cell (TNC) counts are selected, compared to the distribution of units by TNC available. Therefore, the decision to use a low threshold for banking purposes cannot be supported by economic analysis and may limit the economic viability of future public CB banking. Conclusions: We suggest significantly raising the TNC level used to determine a bankable unit. A level of 125 × 107 TNCs, maybe even 150 × 107 TNCs, might be a viable banking threshold. This would improve the return on inventory investments while meeting transplantation needs based on current selection criteria.

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confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Impact of Selection of Cord Blood Units from the United States and Swiss Registries on the Cost of Banking Operations

Bart

Boo

Balabanova

et al. 2013

Transfus Med Hemother

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“…[78][79][80][81][82] Collection costs include costs of recruiting donors, collection kit supplies, and labor costs. These costs may vary based on the recruitment efforts conducted, as well as whether the bank uses volunteer CBU collectors (which is most common), or whether it employs its own CBU collectors.…”

Section: Variable%and%fixed%costs%of%cord%blood%banking%%mentioning

confidence: 99%

Challenges to the Sustainability of the U.S. Public Cord Blood System

Kapinos¹,

Briscombe²,

Gračner³

et al. 2017

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“…Additionally, various indicators such as the total nucleated cell number and CD34+ cell content are followed. Taking into account all these factors, some authors have estimated that approximate 39% of UCB collected units must be discarded [9,10]. NETCORD standards for UCB harvesting, processing, testing, selection and storage, impose that UCB have to be yielded only from uncomplicated deliveries.…”

Section: Discussionmentioning

confidence: 99%

Optimizing donor selection in order to establish a cord blood banking facility: maternal and obstetric factors impact

Chivu¹,

Nastasia

Sultana³

et al. 2007

Open Medicine

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AbstractIn this study, we analyzed the obstetric factors affecting total nucleated cells (TNC) content of cord blood units to establish the criteria for umbilical cord blood (UCB) donor selection in our geographic area.UCB was collected from normal uncomplicated pregnancies. In every case, following data were recorded: (1) gestation length; (2) type of delivery (cesarean or vaginal); and (3) newborn characteristics: weight and sex. For each sample, TNC content, percentage and number of CD34+ cells, and viability were analyzed.The results showed that TNC content increases with cord blood volume, gestational length and newborn weight. The mean blood volume and the mean TNC per unit were 42.37 ± 13.5 ml and 55.49 ± 19.4 × 107, respectively. Stepwise regression analysis revealed a positive and significant correlation (r= 0.89) between these two variables. Meanwhile the CD34+ cell content remains unchanged in deliveries at 32–40 weeks of gestation. The mean CD34+ percentage obtained was 0.37 ± 0.06, and the total number of CD34+ cells was 4.827 ± 0.8204 × 104 / mL UCB.Concluding, the maternal and obstetric factors have a significant impact on UCB cell quantity and quality. The main criteria for UCB collection and storage resulted to be: a gestational age higher than 36–40 weeks and newborn weight > 3200g; gestation number ≤ 2 and placental weight > 700g can be added to the standard criteria to improve the bank efficiency. Our results have also become helpful in evaluating stored UCB units to establish the adequacy for clinical transplant utilization.

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Reasons for discard of umbilical cord blood units before cryopreservation

Cited by 26 publications

References 7 publications

Impact of Selection of Cord Blood Units from the United States and Swiss Registries on the Cost of Banking Operations

Impact of Selection of Cord Blood Units from the United States and Swiss Registries on the Cost of Banking Operations

Challenges to the Sustainability of the U.S. Public Cord Blood System

Optimizing donor selection in order to establish a cord blood banking facility: maternal and obstetric factors impact

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