Reasons for Hospitalization and All-Cause Mortality for Adults with Sarcoidosis

Manansala, Michael; Sami, Faria; Arora, Shilpa; Manadan, Augustine

doi:10.1016/j.ajmo.2023.100037

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…The de-identified nature of the NIS waives the need for Ethics and Institution-al Review Board approvals. All ICD-10 codes used for our study are available in Supplementary 1 [11][12][13][14][15][16][17].…”

Section: Study Populationmentioning

confidence: 99%

Characteristics and clinical outcomes of patients with Sarcoidosis admitted for ST-elevation myocardial infarction in the United States: A propensity matched analysis from the National Inpatient Sample

Ahmed,

Najam,

Ramphul

et al. 2024

Arch Med Sci Atheroscler Dis

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IntroductionSarcoidosis is a systemic inflammatory disorder characterised by non-caseating granulomas. Cardiac sarcoidosis (CS) normally causes conduction abnormalities, ventricular arrhythmias, and heart failure. Little is known about the characteristics and impact of sarcoidosis in patients admitted with ST-elevation myocardial infarction (STEMI). This study aims to fill this void.Material and methodsUtilising the National Inpatient Sample (NIS) database (2016–2020), individuals with STEMI were identified and categorised based on sarcoidosis presence whilst adjusting for confounders via logistic regression models.ResultsAmong 851,290 STEMI patients, 1215 had sarcoidosis. Before propensity matching, sarcoidosis patients were notably different in demographics and comorbidities compared to non-sarcoidosis patients. After propensity score matching (PSM), sarcoidosis patients were found to have a higher incidence of supraventricular tachycardia (SVT) (2.5% vs. 1.3%, p = 0.024) and acute kidney injury (AKI) (23.3% vs. 20.8%, aOR = 1.269, 95% CI: 1.02–1.58, p = 0.033) but a lower incidence of undergoing coronary artery bypass graft (CABG) (5.5% vs. 8.5%, aOR = 0.663; 95% CI: 0.472–0.931, p = 0.018), while no significant disparities were noted in PCI, cardiogenic shock, mortality, or mean length of stay (LOS).ConclusionsUsing propensity-matched large real-world data of STEMI patients, sarcoidosis was associated with fewer cases of CABG and a greater incidence of AKI and SVT compared to non-sarcoidosis patients.

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Section: Study Populationmentioning

confidence: 99%

Characteristics and clinical outcomes of patients with Sarcoidosis admitted for ST-elevation myocardial infarction in the United States: A propensity matched analysis from the National Inpatient Sample

Ahmed,

Najam,

Ramphul

et al. 2024

Arch Med Sci Atheroscler Dis

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Racial disparities among patients with cardiac sarcoidosis and arrhythmias in the United States: A propensity matched-analysis from the national inpatient sample database 2016-2020

Ahmed,

Shahbaz,

Ramphul

et al. 2024

Current Problems in Cardiology

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Nationwide Analysis of Variables Associated With Sarcoid Inpatient Mortality

Manansala,

Castellino,

Arora

et al. 2024

J Clin Rheumatol

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Background Sarcoidosis is a multisystem autoimmune disease that can result in significant morbidity and mortality. This study aims to identify factors associated with in-hospital death for sarcoid patients on a national level. Methods We performed a medical records review study of all adult sarcoid hospitalizations from 2016 to 2020 National Inpatient Sample database. A univariable screen followed by multivariable analysis was completed to identify predictors of in-hospital death among sarcoid patients. Results There were 405,650 admissions with a diagnosis of sarcoidosis, 10,210 of whom died. Multivariable analysis showed the following factors were independently associated with a higher odds of in-hospital death: age (odds ratio [OR], 1.03; 95% confidence interval [CI], 1.026–1.034), Charlson Comorbidity Index (OR, 1.09; 95% CI, 1.066–1.116), male sex (OR, 1.21; 95% CI, 1.101–1.331), other race (OR, 1.45; 95% CI, 1.073–1.954), arrhythmia/heart blocks (OR, 1.80; 95% CI, 1.617–1.995), cirrhosis/hepatic failure (OR, 8.26; 95% CI, 6.928–9.844), hemophagocytic lymphohistiocytosis (OR, 11.15; 95% CI, 4.172–29.802), infection (OR, 3.31; 95% CI, 3.007–3.633), interstitial lung disease (OR, 1.31; 95% CI, 1.193–1.438), heart failure/myocarditis (OR, 1.29; 95% CI, 1.157–1.436), neurologic diagnoses (OR, 1.37; 95% CI, 1.241–1.502), and pulmonary hypertension (OR, 1.47; 95% CI, 1.305–1.652). Conclusions Our multiyear national analysis showed that 2.5% of hospital admissions with a sarcoid diagnosis ended in death. The following factors were associated with death: age, Charlson Comorbidity Index, male sex, other race, arrhythmia/heart blocks, cirrhosis/hepatic failure, hemophagocytic lymphohistiocytosis, infection, interstitial lung disease, heart failure/myocarditis, neurologic diseases, and pulmonary hypertension. This information can help clinicians by improving awareness of these life-threatening complications because early recognition and intervention may improve inpatient sarcoid outcomes.

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Reasons for Hospitalization and All-Cause Mortality for Adults with Sarcoidosis

Cited by 3 publications

References 18 publications

Characteristics and clinical outcomes of patients with Sarcoidosis admitted for ST-elevation myocardial infarction in the United States: A propensity matched analysis from the National Inpatient Sample

Characteristics and clinical outcomes of patients with Sarcoidosis admitted for ST-elevation myocardial infarction in the United States: A propensity matched analysis from the National Inpatient Sample

Racial disparities among patients with cardiac sarcoidosis and arrhythmias in the United States: A propensity matched-analysis from the national inpatient sample database 2016-2020

Nationwide Analysis of Variables Associated With Sarcoid Inpatient Mortality

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