Reassessing referral of touch following peripheral deafferentation: The role of contextual bias

Amoruso, Elena; Terhune, Devin Blair; Kromm, Maria; Kirker, Stephen; Muret, Dollyane; Makin, Tamar R.

doi:10.1016/j.cortex.2023.04.019

Cited by 6 publications

(4 citation statements)

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“…3b ). As subjective reports are particularly malleable to task demands 17 , we also compared the training group with the untrained group (responding to the statements 1 week apart). This allowed us to confirm increased embodiment (post- minus pre-training ratings) in the trained groups relative to the untrained group (for body ownership, W = 263.0; P = 0.045; r rb = −0.32; 95% CI, [−0.57, −0.02]; for agency, W = 81.0; P < 0.001; r rb = −0.79; 95% CI, [−0.88, −0.64]; for visual appearance, W = 169.50; P < 0.001; r rb = −0.56; 95% CI, [−0.74, −0.31]; Fig.…”

Section: Resultsmentioning

confidence: 99%

Biomimetic versus arbitrary motor control strategies for bionic hand skill learning

Schone,

Udeozor,

Moninghoff

et al. 2024

Nat Hum Behav

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A long-standing engineering ambition has been to design anthropomorphic bionic limbs: devices that look like and are controlled in the same way as the biological body (biomimetic). The untested assumption is that biomimetic motor control enhances device embodiment, learning, generalization and automaticity. To test this, we compared biomimetic and non-biomimetic control strategies for non-disabled participants when learning to control a wearable myoelectric bionic hand operated by an eight-channel electromyography pattern-recognition system. We compared motor learning across days and behavioural tasks for two training groups: biomimetic (mimicking the desired bionic hand gesture with biological hand) and arbitrary control (mapping an unrelated biological hand gesture with the desired bionic gesture). For both trained groups, training improved bionic limb control, reduced cognitive reliance and increased embodiment over the bionic hand. Biomimetic users had more intuitive and faster control early in training. Arbitrary users matched biomimetic performance later in training. Furthermore, arbitrary users showed increased generalization to a new control strategy. Collectively, our findings suggest that biomimetic and arbitrary control strategies provide different benefits. The optimal strategy is probably not strictly biomimetic, but rather a flexible strategy within the biomimetic-to-arbitrary spectrum, depending on the user, available training opportunities and user requirements.

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Section: Resultsmentioning

confidence: 99%

Biomimetic versus arbitrary motor control strategies for bionic hand skill learning

Schone,

Udeozor,

Moninghoff

et al. 2024

Nat Hum Behav

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“…These results are in accordance with previous reports of the presence of RS after ICNs-MCN transfer aiming at the biceps motor recovery 22,30,31,[38][39][40][41] . It is important to highlight that the referred sensation screening included clear and systematic instructions to participants, aiming to avoid inductions of false RS as already demonstrated 34 . Confirming the results found in our sample, and to the best of our knowledge, no RS was ever reported after an Oberlin´s nerve transfer nor after a radial to axillary nerve transfer, or after an accessory to suprascapular nerve transfer.…”

Section: Discussionmentioning

confidence: 99%

“…If, during the stimuli, no sensation was evoked at a particular point, then it was considered a point of anaesthesia. To avoid any possible bias demand characteristics of the experimental protocol 34 , we have decided to not indicate to the participants that the sensation could be felt in more than one place.…”

Section: Sensory Evaluation Experiments 1: Referred Sensation Screeningmentioning

confidence: 99%

Mapping Referred Sensation In Traumatic Brachial Plexus Injury Patients

Schmaedeke,

Erthal,

Vargas

et al. 2024

Preprint

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BackgroundReferred sensation (RS) is described as the sensation evoked in the skin areas other than the stimulated region. The aim of the study was to identify and map RS in traumatic brachial plexus injury (TBPI) patients through a standardised assessment.MethodsIn Experiment 1, 12 patients underwent an RS screening by stimulating 22 skin areas distributed in both upper limbs, neck, and face with a cotton swab. In Experiment 2, a detailed RS mapping employing Semmes-Weinstein monofilament was performed at the reinnervated forearm of three subjects who showed RS in experiment 1 screening. In one of these patients, RS mapping was performed over a time span of 6.3 years.ResultsScreening of TBPI patients submitted to different reconstructive surgeries revealed RS only in the patients who underwent intercostal to musculocutaneous nerve (ICN-MCN) transfer. RS systematic mapping of these patients revealed a unique distribution in the forearm and the chest, without any clear topographic organisation. Longitudinal assessment in one of the tested participants showed a scattered expansion of the RS throughout time.ConclusionsThis is the first study to map systematically the RS in patients with TBPI. RS was identified only after ICN-MCN transfer. A possible explanation for this phenomenon is that the greater distance between the representations of the donor and receptor nerves at the primary somatosensory cortex (S1) could constrain plastic reorganisation and thus limit the disentangling of the forearm and chest sensations.

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“… 37 However, these studies have not included placebo control conditions and multiple lines of evidence challenge the presumed mechanistic basis of these effects. 38 39 …”

Section: Current Applications Of Vrmentioning

confidence: 99%

Virtual reality in functional neurological disorder: a theoretical framework and research agenda for use in the real world

Brouwer,

Morrin,

Nicholson

et al. 2024

BMJ Neurol Open

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Functional neurological disorder (FND) is a common and disabling condition at the intersection of neurology and psychiatry. Despite remarkable progress over recent decades, the mechanisms of FND are still poorly understood and there are limited diagnostic tools and effective treatments. One potentially promising treatment modality for FND is virtual reality (VR), which has been increasingly applied to a broad range of conditions, including neuropsychiatric disorders. FND has unique features, many of which suggest the particular relevance for, and potential efficacy of, VR in both better understanding and managing the disorder. In this review, we describe how VR might be leveraged in the treatment and diagnosis of FND (with a primary focus on motor FND and persistent perceptual-postural dizziness given their prominence in the literature), as well as the elucidation of neurocognitive mechanisms and symptom phenomenology. First, we review what has been published to date on the applications of VR in FND and related neuropsychiatric disorders. We then discuss the hypothesised mechanism(s) underlying FND, focusing on the features that are most relevant to VR applications. Finally, we discuss the potential of VR in (1) advancing mechanistic understanding, focusing specifically on sense of agency, attention and suggestibility, (2) overcoming diagnostic challenges and (3) developing novel treatment modalities. This review aims to develop a theoretical foundation and research agenda for the use of VR in FND that might be applicable or adaptable to other related disorders.

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Reassessing referral of touch following peripheral deafferentation: The role of contextual bias

Cited by 6 publications

References 64 publications

Biomimetic versus arbitrary motor control strategies for bionic hand skill learning

Biomimetic versus arbitrary motor control strategies for bionic hand skill learning

Mapping Referred Sensation In Traumatic Brachial Plexus Injury Patients

Virtual reality in functional neurological disorder: a theoretical framework and research agenda for use in the real world

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