2019
DOI: 10.1101/748871
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Reassessing the validity of slow-wave dynamics as a proxy for NREM sleep homeostasis

Abstract: Sleep-wake driven changes in NREM sleep (NREMS) EEG delta (δ: ~0.75-4.5Hz) power are widely used as proxy for a sleep homeostatic process. We noted frequency increases in δ-waves in sleep-deprived (SD) mice, prompting us to re-evaluate how slow-wave characteristics relate to prior sleep-wake history. We discovered two types of δ-waves; one responding to SD with high initial power and fast, discontinuous decay (δ2: ~2.5-3.5Hz) and another unrelated to time-spentawake with slow, linear decays (δ1: ~0.75-1.75Hz).… Show more

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