Introduction
The twelve-lead surface electrocardiogram (ECG) is commonly used as a non-invasive modality to assess for left atrial enlargement (LAE), but data comparing ECG against cardiac computed tomography (CT) for LAE is lacking. We aimed to determine the diagnostic performance of six ECG criteria for LAE as compared to CT left atrial volume (LAV) and index to body surface area (LAVI) as the reference standard.
Materials and Methods
In 339 patients (age 53±12 years, 63% male), we evaluated the quantitative ECG parameters of P duration, P to PR segment ratio, P wave area, and P terminal force (PTFV1). We also assessed qualitatively the morphology of bifid and biphasic P waves. Patients were stratified into top and lowest quartile of LAV and LAVI by CT.
Results
Of the six ECG criteria, patients with P duration>110 ms had a 2½-fold increase likelihood of being in the top quartile of LAV (adjusted odds ratio [OR] OR 2.51, p=0.01) and LAVI (adjusted OR 2.74; p=0.007) as measured by CT. For this ECG criterion, the sensitivity and specificity were 71% and 55% for CT LAE by LAV and 61% and 55% for LAVI. The remaining ECG parameters of LAE assessed (P to PR segment ratio, PTFV1, P wave area, bifid, and biphasic P wave) were not associated with LAE by CT-based LAV or LAVI (all p≥0.20).
Discussion
Only P duration>110 ms was independently associated with LAE based on CT-derived LA volume and index. However, none of the established ECG parameters of LAE have sufficient diagnostic accuracies for predicting volumetric enlargement by CT, thus limiting its clinical utility.