Reassessment of gastric lymphoma in light of the concept of mucosa-associated lymphoid tissue lymphoma

Hoshida, Yoshihiko; Kusakabe, Hiroshi; Furukawa, Hiroshi; Kasugai, Tsutomu; Miwa, Hideaki; Ishiguro, Shingo; Aozasa, Katsuyuki

doi:10.1002/(sici)1097-0142(19970915)80:6<1151::aid-cncr19>3.0.co;2-7

Cited by 28 publications

(13 citation statements)

References 34 publications

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“…However, the correlation between grade and age reported in several series 21,33,34 was not observed in our study, which is also true for at least two other series reported from Spain 25 and Japan. 32 Grade is known to increase in gastric lymphoma patients as age at diagnosis gets older. Conversely, there is a tendency toward a reverse association in this study although statistically insignificant.…”

supporting

confidence: 91%

“…In several recent reports that consider the concept of MALT lymphoma, it is shown that the presence of a significant high grade component in a low grade lymphoid infiltrate results in a tumor behavior very similar to that of a high grade lymphoma. 21,31,32 In this study, the proportion of patients in low versus intermediate and high grade histologies was 15% and 85% (48% intermediate grade, 37% high grade), respectively, which is in accordance with the literature. However, the correlation between grade and age reported in several series 21,33,34 was not observed in our study, which is also true for at least two other series reported from Spain 25 and Japan.…”

mentioning

confidence: 99%

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Gastric lymphomas in Turkey

Aydın

Barışta

Canpınar

et al. 2000

Cancer

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supporting

confidence: 91%

mentioning

confidence: 99%

Gastric lymphomas in Turkey

Aydın

Barışta

Canpınar

et al. 2000

Cancer

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“…perficial spreading type without ulceration, whereas high-grade lymphoma was a tumorforming type [23]. That study found no tumorforming type in the low-grade lymphoma and no superficial spreading type without ulceration in the high-grade lymphoma [23].…”

Section: B Amentioning

confidence: 66%

“…That study found no tumorforming type in the low-grade lymphoma and no superficial spreading type without ulceration in the high-grade lymphoma [23].…”

Section: B Amentioning

confidence: 99%

“…These findings reflect the tumor-forming type in high-grade lymphoma, and the wall thickness was proportional to the depth of invasion on the histopathologic specimen. Our results were consistent with the reports showing that the depth of invasion is strongly correlated with the histologic type within the submucosa in the low-grade lymphoma (50-68%) and beyond the muscularis propria in the high-grade group (78-100%) [5,23].…”

Section: B Amentioning

confidence: 99%

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Radiographic Findings of Primary B-Cell Lymphoma of the Stomach: Low-Grade Versus High-Grade Malignancy in Relation to the Mucosa-Associated Lymphoid Tissue Concept

Park

Kim

et al. 2002

American Journal of Roentgenology

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OBJECTIVE. We undertook this study to assess how well double-contrast radiography and CT allow radiologists to differentiate low-grade from high-grade mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach. MATERIALS AND METHODS.We retrospectively reviewed the upper gastrointestinal radiographs and contrast-enhanced CT scans of 57 patients with pathologically proven primary gastric lymphoma (low-grade [ n = 29] and high-grade [ n = 28] MALT lymphoma).RESULTS. On upper gastrointestinal radiography, ulceration (39%) was the most common finding in low-grade lymphoma, whereas polypoid appearance (38%) was the most common in high-grade lymphoma. In the 29 patients (33 lesions) with low-grade MALT lymphoma, upper gastrointestinal radiography revealed 13 ulcerative lesions (39%), 10 nodular lesions (30%), four infiltrative lesions (12%), two polypoid lesions (6%), and four combined lesions (12%). In the 28 patients (29 lesions) with high-grade lymphoma, upper gastrointestinal radiography revealed 11 polypoid lesions (38%), nine infiltrative lesions (31%), six ulcerative lesions (20%), one nodular lesion (3%), and two combined lesions (7%). On CT, thickening of the gastric wall in low-grade lymphoma (range, 0.3-2.5 cm; mean, 0.8 cm) was much less than that in high-grade lymphoma (range, 0.7-8.0 cm; mean, 2.5 cm). Abdominal lymphadenopathy was less frequent in low-grade lymphoma (14%) than in high-grade lymphoma (75%).CONCLUSION. Most low-grade lymphomas show superficial spreading lesions, such as mucosal nodularity, shallow ulcer, and minimal fold thickening, on upper gastrointestinal radiography, whereas most high-grade lymphomas show mass-forming lesions or severe fold thickening.

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