Reassessment of Lhermitte’s sign in multiple sclerosis

Abstract

The reliability and diagnostic value of Lhermitte's sign in multiple sclerosis (MS) has not been fully established. The purpose of this study was to determine the clinical, neurophysiological and neuroradiological correlations of Lhermitte's sign in a cohort of MS patients and reassess the relevance of this phenomenon in the clinical history of the disease. A prospective study of 694 patients with MS and 110 age-matched healthy adults was evaluated by a structured questionnaire that included basic demographic data, age of onset, clinical characteristics of the disease, and the inquiry of Lhermitte's sign. Cranial and spinal magnetic resonance imagings (MRI) and median and tibial somatosensory evoked potentials (SSEP) were performed at the same time. One hundred and twelve (16 %) patients were reported to have Lhermitte's sign; 582 (84 %) patients did not experience Lhermitte's sign during their disease duration (P < 0.026). No correlation was found between Lhermitte's sign and age, gender, EDSS, and disease duration; 88 % of patients with Lhermitte's sign had a demyelinating lesion on the cervical MRI. In negative Lhermitte's sign group, 64 % patients had a positive MRI. SSEP conductions were delayed in 92 % of patients with positive Lhermitte's sign and in 70 % of patients with negative Lhermitte's sign. Regarding the data, a significant correlation was found between MRI lesion and Lhermitte's sign (P < 0.001), and between SSEP abnormality and Lhermitte's sign as well (P < 0.001). This study underlines the relevance of this phenomenon with neuroradiological and neurophysiological abnormalities.

Temperature sensitivity in multiple sclerosis: An overview of its impact on sensory and cognitive symptoms

“…40-80% of the patients claim that paraesthesia symptoms (tingling) affect their daily life, especially when they become persistent [56,62]. Furthermore, some people with MS may experience dysaesthesia and Lhermitte's phenomenon as a result of spinal cord demyelination [63,64]. Dysaesthesia is manifested as an intense pain of pins and needles and burning sensation, usually present in the extremities [58,65].…”

Oxaliplatin-Induced Lhermitte’s Sign in Gastric Cancer

“…Magnetic resonance imaging (MRI) of the cervical spine is indicated to rule out spinal cord injury. Demyelination is more likely to be detected in multiple sclerosis patients with Lhermitte's sign than those without [22]. On the other hand, no MRI abnormalities were noted in a study of 5 OLS patients [12].…”

Jacques Jean Lhermitte and Lhermitte’s sign

“…20–22 However, a more recent prospective study of 694 multiple sclerosis patients found that about 16% of the patient cohort experienced Lhermitte’s sign and that this was significantly correlated with neuroradiological and neurophysiological abnormalities. 23 While further studies are still needed to critically assess Lhermitte’s sign, its presence in other spinal and radicular pathologies reinforces that enquiring about Lhermitte’s sign during neurological examination should be a mainstay of clinical practice. 22…”