Reassessment of small lymphocytic lymphoma in the era of monoclonal B-cell lymphocytosis

Gibson, Sarah E.; Swerdlow, Steven H.; Ferry, Judith A.; Surti, Urvashi; Cin, Paola Dal; Harris, Nancy L.; Hasserjian, Robert P.

doi:10.3324/haematol.2011.042333

Cited by 80 publications

(63 citation statements)

References 37 publications

(80 reference statements)

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“…This is a crucial issue because previous studies 11 as well as more recent reports 15 showed that an under-recognized grey zone between SLL and cMBL may exist. This raises concerns about the fact that at least a portion of the cases classified as cMBL could represent SLL with a low and hidden nodal burden, and cast doubts on the appropriateness of a simple physical examination in the workup of cMBL patients.…”

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confidence: 94%

Impact of B-cell count and imaging screening in cMBL: any need to revise the current guidelines?

et al. 2012

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one intensification cycle of high-dose cytarabine and etoposide (HAE). The patient received a prophylactic cranial irradiation and intrathecal therapy with cytarabine. Allogeneic stem cell transplantation was not performed because of the lack of a HLAidentical sibling donor. A maintenance therapy with 6-thioguanine and cytarabine was given. The patient remained in remission and was discharged from hospital after 8 months of treatment. After 6 months, the patient was hospitalized because of weight loss, thrombocytopenia and hepatosplenomegaly. Repeated bone marrow examinations revealed no evidence for AML relapse. In the following, the patient suffered from a severe aspergillus sepsis and died due to a septic multiple organ failure with bleeding complications.To our knowledge, this is the first report to describe a somatic EZH2 mutation in pediatric AML. Although EZH2 mutations seem to be rare in childhood AML, our findings indicate that EZH2 mutations might contribute to the disease in specific cases. The incidence of EZH2 mutations in childhood AML needs to be assessed in a larger cohort of patients particularly in children with t(8;21).

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confidence: 94%

Impact of B-cell count and imaging screening in cMBL: any need to revise the current guidelines?

et al. 2012

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“…However, a recent study suggested that limited nodal involvement, usually discovered incidentally, was still compatible with a diagnosis of MBL. 30 Risk factors for progression included lymphadenopathy greater than 1.5 cm by imaging and the presence of proliferation centers on histology. Bone marrow biopsies in patients with MBL have shown patchy interstitial lymphoid infiltrates indistinguishable from low-level involvement by CLL and a diagnosis of CLL should not be made on this evidence alone without supporting clinical information.…”

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confidence: 99%

Early lymphoid lesions: conceptual, diagnostic and clinical challenges

et al. 2014

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“…20 Recently, one study has proposed lymph node size to be a criterion for separating small lymphocytic lymphoma/chronic lymphocytic leukemia from monoclonal B lymphocytosis in lymph nodes, 21 but this is not applicable to the cases considered here. This observation confirms and expands previous descriptions of clonal B-cell population in the blood of HCV-infected persons, as well as clonal B-cell infiltrates in the bone marrow and liver biopsies of patients with HCV infection, associated or not with cryoglobulinemia.…”

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confidence: 99%

Hepatitis C virus-related lymphoproliferative disorders encompass a broader clinical and morphological spectrum than previously recognized: a clinicopathological study

et al. 2014

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We describe a retrospective series of B-cell lymphoproliferative disorders associated with hepatitis C virus infection. In addition to splenic marginal zone lymphoma, follicular lymphoma and diffuse large B-cell lymphoma, all of which showed some specific features, we found two poorly described groups of cases. The first featured disseminated marginal zone lymphoma without splenic marginal zone lymphoma features, defying the current marginal zone lymphoma classification; the other consisted of monoclonal B lymphocytes in the peripheral blood, bone marrow or other tissues, with no clinical or histological evidence of lymphoma, and exhibiting a pattern that requires proper identification in order to avoid the misdiagnosis of the lymphoma. Diagnosis of hepatitis C virus infection-associated lymphoproliferative disorders requires the integration of clinical, pathological and molecular findings to establish an adequate diagnosis and decide the appropriate therapy to be applied.

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Reassessment of small lymphocytic lymphoma in the era of monoclonal B-cell lymphocytosis

Cited by 80 publications

References 37 publications

Impact of B-cell count and imaging screening in cMBL: any need to revise the current guidelines?

Impact of B-cell count and imaging screening in cMBL: any need to revise the current guidelines?

Early lymphoid lesions: conceptual, diagnostic and clinical challenges

Hepatitis C virus-related lymphoproliferative disorders encompass a broader clinical and morphological spectrum than previously recognized: a clinicopathological study

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