Rebalancing NOX2/Nrf2 to limit inflammation and oxidative stress across gut-brain axis in migraine

Ardizzone, Alessio; Capra, Anna Paola; Repici, Alberto; Lanza, Marika; Bova, Valentina; Palermo, Nicoletta; Paterniti, Irene; Esposito, Emanuela

doi:10.1016/j.freeradbiomed.2024.01.018

Cited by 9 publications

(1 citation statement)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The microbiota-gut-brain axis is a bidirectional route of homeostatic communication via epigenetic mechanisms of diverse metabolites such as SCFAs. Thus, a modulation of the gut microbiota via diet or lifestyle can regulate neuron/brain inflammation via certain epigenetic mechanisms [53], which might be effective for enhancing emotional well-being and/or treating depressive disorders [54]. As important constituents of epigenetics by gut microbial metabolites and/or fermentation products, several miRNAs with epigenetic mechanisms have vital roles in various physiological homeostasis mechanisms [55,56].…”

Section: Connection Between Gut Microbiota and Alcohol Dependencymentioning

confidence: 99%

Potential Molecular Mechanisms of Alcohol Use Disorder with Non-Coding RNAs and Gut Microbiota for the Development of Superior Therapeutic Application

Nakashima,

Suga,

Yoshikawa

et al. 2024

Genes

View full text Add to dashboard Cite

Many investigations have evaluated the expression of noncoding RNAs (ncRNAs) as well as their related molecular functions and biological machineries in individuals with alcohol dependence. Alcohol dependence may be one of the most prevailing psychological disorders globally, and its pathogenesis is intricate and inadequately comprehended. There is substantial evidence indicating significant links between multiple genetic factors and the development of alcohol dependence. In particular, the critical roles of ncRNAs have been emphasized in the pathology of mental illnesses, probably including alcohol dependence. In the comprehension of the action of ncRNAs and their machineries of modification, furthermore, they have emerged as therapeutic targets for a variety of psychiatric illnesses, including alcohol dependence. It is worth mentioning that the dysregulated expression of ncRNAs has been regularly detected in individuals with alcohol dependence. An in-depth knowledge of the roles of ncRNAs and m6A modification may be valuable for the development of a novel treatment against alcohol dependence. In general, a more profound understanding of the practical roles of ncRNAs might make important contributions to the precise diagnosis and/or actual management of alcohol dependence. Here, in this review, we mostly focused on up-to-date knowledge regarding alterations and/or modifications in the expression of ncRNAs in individuals with alcohol dependence. Then, we present prospects for future research and therapeutic applications with a novel concept of the engram system.

show abstract