Rebirth of Aspirin Synthesis By‐Product: Prickly Poly(salicylic acid) Nanoparticles as Self‐Anticancer Drug Carrier

Abstract

As a great drug, aspirin has been used to treat many important diseases. To expand the biomedical applications of the aspirin material family, in this report, the authors polymerized salicylic acid (functional part of aspirin) into poly (salicylic acid) (PSA), which was once a by‐product during aspirin synthesis. PSA can be formulated into sub‐100 nm prickly nanoparticles (NPs) via a nanoprecipitation self‐assembly procedure. The PSA NPs are found to be nontoxic to normal cells and cancer cells, but can inhibit tumor growth in the CT26 mouse model. The anticancer drug can be effectively loaded into PSA NPs and the drug‐loaded PSA NPs show ultra‐high blood vessel penetration, tumor penetration, and tumor accumulation due to the special prickly nanostructure. With these combined advantages, including the self‐therapeutic effects, high biosafety, and high tumor accumulation performance, drug‐loaded PSA NPs achieved a significant tumor inhibition efficacy without causing any side effects. Therefore, a new poly (salicylic acid) NP platform is successfully developed from a byproduct of aspirin synthesis, expanding the biomedical applications of aspirin‐related materials.

A BRD4 PROTAC nanodrug for glioma therapy via the intervention of tumor cells proliferation, apoptosis and M2 macrophages polarization

“…Herein, the small size brain-targeting SPP-ARV-825 drug micelle was developed for glioma therapy. Nanoplatform delivery system has been widely used for drug delivery due to its advantages of good bioavailability, sustained drug release and reduced side effects 62 , 63 , 64 . As a promising anti-tumor drug candidate, the low water solubility of ARV-825 limits its application in cancer therapy.…”

The Emerging Role of Tissue-Resident Memory CD8+ T Lymphocytes in Human Digestive Tract Cancers

“…It has been reported that biodegradable polymers such as poly (ursolic acid) are used as drug carriers for treating CRC and other cancers. The anticancer drug effectively loaded into poly(salicylic acid) nanoparticles shows ultrahigh blood vessel penetration, tumor penetration, and tumor accumulation due to the special prickly nanostructure (107,108). Thus, the combination of a therapeutic polymer platform and immunotherapy to achieve precise targeted therapy may be a new attractive therapeutic strategy for treating digestive tract cancer.…”

Restorative biodegradable two-layered hybrid microneedles for melanoma photothermal/chemo co-therapy and wound healing

“…Clinically, surgical resection has been the most widely applied treatment for melanoma but suffered from the high risk of recurrence [ 5 ]. Other alternative therapeutic strategies have been investigated to eradicate the melanoma cells, including the chemo/radiotherapy and photodynamic therapy (PDT) [ 6 ]. Unfortunately, melanoma is resistant to the traditional chemo/radiotherapy which could bring about endless pain to patients [ 7 ].…”