Rebt With Pharmacotherapy in the Management of Chronic Pain- A Quasiexperimental Study

Abstract

BACKGROUNDIn the recent past, there has been an increase in the number of patients who seek specialist neurological consultations for chronic pain which need longterm pharmacotherapy due to associated biopsychosocial issues.The aim of the present study was to evaluate the efficacy of Rational Emotive Behaviour Therapy (REBT) and Pharmacotherapy in the management of pain. The objectives of the present study were to determine the associated underlying anxiety, depression and stress in patients with chronic pain; and to compare the efficacy of different treatment modalities like REBT, psychoeducation and pharmacotherapy in the management of chronic pain.

Unperturbed Detection of the Dynamic Structure in the Hydrophobic Core of Trp-Cage via Two-Dimensional Infrared Spectroscopy

“…The secondary structure of the folded protein includes a hydrophobic core formed around a central tryptophan (Trp) residue. 9,10 The protein tertiary structural motif includes an N-terminal αhelix, followed by a short 3 10 helix and a C-terminal PolyproIine II (PPII) helix. The hydrophobic core of the Trp-cage contains seven residues: Tyr3, Trp6, Leu7, Gly11, Pro12, Pro18, and Pro19.…”

“…3,13,25,33 The MD simulations show the critical influence of Trp6 conformations on the Trp-cage folding process. 10 Gai and co-workers examined the folding process of Trpcage with more detail utilizing T-jump to acquire a sequential folding mechanism. According to this study, the 3 10 -helix unfolds first, followed by the α-helix, which is required for cage formation ultimately leading to the global unfolding of the miniprotein.…”

Preparação e caracterização de hidróxidos duplos lamelares intercalados com espécies macrocíclicas metaladas

“…Um estudo sintético para encontrar as melhores condições e método de síntese para o isolamento de fase puras de HDLs do tipo ZnnAI (n=1-5) intercalados com porfirinas aniônicas não metaladas (base livre) foi realizado por Bonnet et aI. via método da coprecipitação foram caracterizados por Kannan et aI [80]…”