2016
DOI: 10.1242/dev.143842
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Rebuilding a broken heart: lessons from developmental and regenerative biology

Abstract: In May 2016, the annual Weinstein Cardiovascular Development and Regeneration Conference was held in Durham, North Carolina, USA. The meeting assembled leading investigators, junior scientists and trainees from around the world to discuss developmental and regenerative biological approaches to understanding the etiology of congenital heart defects and the repair of diseased cardiac tissue. In this Meeting Review, we present several of the major themes that were discussed throughout the meeting and highlight th… Show more

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Cited by 6 publications
(5 citation statements)
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“…Understanding the gene regulatory networks (GRNs) governing cardiac organogenesis could lead to innovations for the treatment of both inherited and acquired heart disease 1 , 2 . In addition, induction of cardiac regeneration via either cell-based therapies or reactivation of dormant endogenous mechanisms has engendered considerable interest over the past decade 3 . Both approaches require a deep knowledge of the molecular and cellular events regulating cardiac specification and differentiation.…”
Section: Introductionmentioning
confidence: 99%
“…Understanding the gene regulatory networks (GRNs) governing cardiac organogenesis could lead to innovations for the treatment of both inherited and acquired heart disease 1 , 2 . In addition, induction of cardiac regeneration via either cell-based therapies or reactivation of dormant endogenous mechanisms has engendered considerable interest over the past decade 3 . Both approaches require a deep knowledge of the molecular and cellular events regulating cardiac specification and differentiation.…”
Section: Introductionmentioning
confidence: 99%
“…Tremendous progress has been made in understanding how the mutations affect cardiac development. The results have found relevance to clinical problems such as arrhythmia and cardiomyopathy, 67 but how the knowledge can be applied to prevent CHD is far less clear. Nevertheless, we believe that CHD prevention should remain a driving force for research.…”
Section: Future Directionsmentioning
confidence: 99%
“…Experimental studies in model systems are key in investigating molecular mechanisms of cardiac disease and in therapeutic biomarker discovery [1,2]. The presumption underlying any cardiac disease study conducted in a model organism is that the model adequately recapitulates relevant human cardiac physiology.…”
Section: Introductionmentioning
confidence: 99%