Recalcitrant course of bullous pemphigoid indicating coexisting hypereosinophilic syndrome: A case report and literature review

Ganji, Raziyeh; Diab, Reem; Mousavi, Farideh; Abdollahimajd, Fahimeh

doi:10.1002/ccr3.7384

Cited by 1 publication

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More investigations revealed BP associated with hyper-eosinophilic syndrome. Finally, the patient was treated with high dose corticosteroid [21].…”

Section: Discussionmentioning

confidence: 99%

Frequency and Correlation of Peripheral and Tissue Eosinophilia With Clinical Manifestations in Patients With Bullous Pemphigoid

Abtahi-Naeini,

Zare-Mehrjerdi,

Shahmoradi

et al. 2024

Dermatology Practical &Amp; Conceptual

View full text Add to dashboard Cite

Introduction: Bullous pemphigoid (BP) is an autoimmune disease involving the sub-epidermal layer. Eosinophilia may play a role in the pathogenesis of BP. Objectives: We aimed to investigate the correlation between dermal or peripheral eosinophilia with clinical presentations in patients with BP. Methods: This cross-sectional study was conducted on 108 BP patients from January 2010 to September 2019. Clinical data were recovered. Skin biopsies were re-evaluated, and the Bullous Pemphigoid Disease Area Index (BPDAI) severity score was calculated. Finally, the relationship between clinical features of BP and dermal or peripheral eosinophilia was analyzed. Results: A total number of 108 patients were included in this study. Thirty-five were excluded due to our exclusion criteria. Finally, data from 73 patients were analyzed. 57.5% of the population was female. There was a significant direct correlation (r= 0.33) between BPDAI severity score and tissue eosinophilia (p= 0.03). No significant relationship was found between BPDAI severity score and peripheral eosinophilia (P= 0.52). There were significant positive correlations between tissue eosinophilia with absolute serum eosinophil count (P= 0.002; r= 0.49) and percentage (P< 0.0001; r= 0.89). Conclusion: This study revealed significant relationships between tissue eosinophilia and BP severity. These findings could be useful in clinical practice. The possible role of eosinophils in BP clinical features should be considered as a promising help for better diagnosis and treatment.

show abstract

“…More investigations revealed BP associated with hyper-eosinophilic syndrome. Finally, the patient was treated with high dose corticosteroid [21].…”

Section: Discussionmentioning

confidence: 99%

Frequency and Correlation of Peripheral and Tissue Eosinophilia With Clinical Manifestations in Patients With Bullous Pemphigoid

Abtahi-Naeini,

Zare-Mehrjerdi,

Shahmoradi

et al. 2024

Dermatology Practical &Amp; Conceptual

View full text Add to dashboard Cite

show abstract

Recalcitrant course of bullous pemphigoid indicating coexisting hypereosinophilic syndrome: A case report and literature review

Abstract: As dermatologists, we must be aware that even limited localized lesions may signal a life-threatening condition, for which early diagnosis and treatment can improve the prognosis.

Cited by 1 publication

References 10 publications

Frequency and Correlation of Peripheral and Tissue Eosinophilia With Clinical Manifestations in Patients With Bullous Pemphigoid

Frequency and Correlation of Peripheral and Tissue Eosinophilia With Clinical Manifestations in Patients With Bullous Pemphigoid

Contact Info

Product

Resources

About