Recalcitrant erosive plaques on the palms and soles: A rare manifestation of eccrine syringofibroadenoma

A Case of Reactive Eccrine Syringofibroadenoma Associated with Dyshidrotic Eczema

“…2 Based on Starink's classifications modified by French, there are five subtypes of eccrine fibroadenoma: Solitary ESFA, Multiple ESFA associated with hidrotic ectodermal dysplasia (Clouston and Schopf's syndrome), Multiple ESFA without associated cutaneous findings (eccrine syringofibroadenomatosis), Non-familial unilateral linear ESFA (naevoid ES) and Reactive ESFA associated with inflammatory or neoplastic processes. 5,6 ESFA can occur independently or be accompanied by skin ulcers, chronic lymphedema, amyloidosis, toenail trauma, burns, bruises, bullous pemphigoid, epidermolysis bullosa, and other lesions. It can even be associated with or secondary to squamous cell carcinoma.…”

Late‐onset eccrine syringofibroadenoma of the feet in a patient with hypohidrotic ectodermal dysplasia

“…Alternative treatments reported with varying degree of success include the following: radiotherapy, photodynamic therapy, 5-fluorouracil, cryotherapy, curettage, topical/systemic retinoids, etretinate and imiquimod. 3,6,7 extremely rarely transformation into syringofibrocarcinoma has been described, warranting follow-up. 7 Ectodermal dysplasia (ED) is an inherited genetic disorder with abnormalities in more than one ectodermal derivative.…”

“…Solitary ESFA is treated with surgical excision. Alternative treatments reported with varying degree of success include the following: radiotherapy, photodynamic therapy, 5‐fluorouracil, cryotherapy, curettage, topical/systemic retinoids, etretinate and imiquimod 3,6,7 . extremely rarely transformation into syringofibrocarcinoma has been described, warranting follow‐up 7 …”

Erythematous Plaque with Crusting on the Lower Leg: A Quiz

“…Eccrine syringofibroadenoma is a rare benign skin lesion with eccrine ductal differentiation that presents with varying clinical features ( 1 ). ESFA is histologically characterized by anastomosed cords and strands of homogenous cuboidal cells embedded in the fibrovascular stroma.…”