Recall-Dermatitis durch Docetaxel-Reexposition nach Gehirnbestrahlung Fallbeobachtung und Literaturübersicht

Giesel, Barbara U.; Kutz, Gudrun G.; Thiel, Hans-Joachim

doi:10.1007/pl00002431

Cited by 15 publications

(1 citation statement)

References 13 publications

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“…The dose given by Yeo et al was 100 mg/m 2 every 3 weeks [10]; we used 30 mg/m 2 docetaxel, given weekly. Giesel et al applied 30 and 100 mg/m 2 docetaxel in 2 cases and found comparable skin reactions to the described [4]. In the report by Giesel et al docetaxel was well tolerated before and during radiotherapy.…”

Section: Discussionmentioning

confidence: 66%

Radiation Recall Dermatitis from Docetaxel

Piroth¹,

Krempien²,

Wannenmacher³

et al. 2002

Oncol Res Treat

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Background: Experiences with inflammatory skin reactions after treatment with docetaxel and prior exposure to radiotherapy like a recall phenomenon are very rare. We present the case of an uncommon and severe skin reaction after docetaxel application and prior radiotherapy. Patient and Methods: A 40-year-old female was treated with an upper body irradiation with electrons because of relapsed breast cancer. In addition, because of metastases of brain and bone she received radiotherapy on the whole brain and the left pelvis. One week after radiotherapy weekly chemotherapy with docetaxel was started. Results: Radiotherapy was well tolerated. There was a cutaneous erythema RTOG grade 1. After second application of docetaxel the patient developed a severe skin erythema, after fourth application confluent desquamations exactly demarcated the previously irradiated skin area. After discontinuation of docetaxel and after antiinflammatory treatment the skin reactions improved rapidly. Conclusion: In our opinion the severe skin reaction was clearly associated with the application of docetaxel like a recall phenomenon after previous radiotherapy. In case of severe skin reaction after this therapy it is important to know the possibility of recall phenomenon.

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Section: Discussionmentioning

confidence: 66%

Radiation Recall Dermatitis from Docetaxel

Piroth¹,

Krempien²,

Wannenmacher³

et al. 2002

Oncol Res Treat

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Antimicrotubule Agents

Garbe

2013

Dermatologic Principles and Practice in Oncology

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A case of radiation recall mucositis associated with docetaxel

et al. 2004

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Background. Radiation recall reactions, in particular dermatitis, are well documented in the literature. However, radiation recall mucositis is a rare clinical phenomenon.Methods. We report a case of a 45-year-old man diagnosed with squamous cell carcinoma of the base of tongue. He was treated with surgery followed by chemotherapy and radiation therapy. Several months after completing treatment, he had a recurrence develop outside of the previously irradiated field. He was offered radiation therapy concurrent with docetaxel as salvage therapy.Results. During salvage therapy, acute recall mucositis developed corresponding to his previously irradiated fields. His chemotherapy with docetaxel was withheld, and his symptoms rapidly improved.Conclusions. This case describes radiation recall mucositis associated with docetaxel, a rare but potentially serious clinical situation. Given the potential severity of the reaction and increasing use of docetaxel as second-line treatment of recurrent head and neck cancers, it is important to be aware of this phenomenon. B

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Recall-Dermatitis durch Docetaxel-Reexposition nach Gehirnbestrahlung Fallbeobachtung und Literaturübersicht

Cited by 15 publications

References 13 publications

Radiation Recall Dermatitis from Docetaxel

Radiation Recall Dermatitis from Docetaxel

Antimicrotubule Agents

A case of radiation recall mucositis associated with docetaxel

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