Recapitulation of growth factor-enriched microenvironment via BMP receptor activating hydrogel

Zhang, Qinghao; Liu, Yuanda; Li, Jie; Wang, Jing; Liu, Changsheng

doi:10.1016/j.bioactmat.2022.06.012

Cited by 21 publications

(11 citation statements)

References 53 publications

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“…A growth factor-enriched microenvironment (GEM) is beneficial for the regenerative ability of MSCs. Liu et al reported a sulfonated gelatin hydrogel which can significantly amplify bone morphogenesis protein-2 (BMP-2) receptor activation via enhancing the binding between BMP-2 and BMP-2 type II receptors (BMPR2) [ 202 ]. The amplified BMP-2 receptor activation enhanced the proliferation and osteogenesis of MSCs and partially rejuvenated the functions of aged MSCs.…”

Section: Therapeutic Approaches To Rejuvenate Aged Mscsmentioning

confidence: 99%

Rejuvenation of Mesenchymal Stem Cells to Ameliorate Skeletal Aging

Cheng

Yuan

Moshaverinia

et al. 2023

Cells

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Advanced age is a shared risk factor for many chronic and debilitating skeletal diseases including osteoporosis and periodontitis. Mesenchymal stem cells develop various aging phenotypes including the onset of senescence, intrinsic loss of regenerative potential and exacerbation of inflammatory microenvironment via secretory factors. This review elaborates on the emerging concepts on the molecular and epigenetic mechanisms of MSC senescence, such as the accumulation of oxidative stress, DNA damage and mitochondrial dysfunction. Senescent MSCs aggravate local inflammation, disrupt bone remodeling and bone-fat balance, thereby contributing to the progression of age-related bone diseases. Various rejuvenation strategies to target senescent MSCs could present a promising paradigm to restore skeletal aging.

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Section: Therapeutic Approaches To Rejuvenate Aged Mscsmentioning

confidence: 99%

Rejuvenation of Mesenchymal Stem Cells to Ameliorate Skeletal Aging

Cheng

Yuan

Moshaverinia

et al. 2023

Cells

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“…In a big prospective study, bone morphogenetic protein-4 (BMP-4) was used as a component of hydrogel with high potential to stimulate chondrogenesis, accelerate the repair of bone–cartilage defects, and preserve the cartilage structure after regeneration [ 178 ]. Additionally, another study developed innovative hydrogel replicates in a growth factor-enriched microenvironment to improve regeneration, which included bone morphogenetic protein-2 (BMP-2) [ 289 ]. BMPs act on cell membrane receptors and regulate the growth, differentiation, and apoptosis of various cell types including osteoblasts, chondroblasts, nerve cells, and epithelial cells [ 178 ].…”

Section: 3d Tissue Bioprintingmentioning

confidence: 99%

3D Bioprinting of Hyaline Articular Cartilage: Biopolymers, Hydrogels, and Bioinks

Volova,

Kotelnikov,

Shishkovsky

et al. 2023

Polymers

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The musculoskeletal system, consisting of bones and cartilage of various types, muscles, ligaments, and tendons, is the basis of the human body. However, many pathological conditions caused by aging, lifestyle, disease, or trauma can damage its elements and lead to severe disfunction and significant worsening in the quality of life. Due to its structure and function, articular (hyaline) cartilage is the most susceptible to damage. Articular cartilage is a non-vascular tissue with constrained self-regeneration capabilities. Additionally, treatment methods, which have proven efficacy in stopping its degradation and promoting regeneration, still do not exist. Conservative treatment and physical therapy only relieve the symptoms associated with cartilage destruction, and traditional surgical interventions to repair defects or endoprosthetics are not without serious drawbacks. Thus, articular cartilage damage remains an urgent and actual problem requiring the development of new treatment approaches. The emergence of biofabrication technologies, including three-dimensional (3D) bioprinting, at the end of the 20th century, allowed reconstructive interventions to get a second wind. Three-dimensional bioprinting creates volume constraints that mimic the structure and function of natural tissue due to the combinations of biomaterials, living cells, and signal molecules to create. In our case—hyaline cartilage. Several approaches to articular cartilage biofabrication have been developed to date, including the promising technology of 3D bioprinting. This review represents the main achievements of such research direction and describes the technological processes and the necessary biomaterials, cell cultures, and signal molecules. Special attention is given to the basic materials for 3D bioprinting—hydrogels and bioinks, as well as the biopolymers underlying the indicated products.

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“…Wound infections caused by the colonization of bacteria pose a great challenge to wound management in clinical practice, especially with the arrival of the postantibiotic era in which many bacteria have become antibiotic-resistant. − Persistent bacterial infections on wounds can produce serious inflammatory responses and hinder the formation of granulation tissues, thus delaying wound healing. − Hydrogel is considered a promising biomaterial for wound care because it mimics the extracellular matrix by presenting a three-dimensional network structure to build a physical barrier on the wound bed, , and it also promotes wound healing through mechanisms such as growth factor delivery, , release of antibacterial peptides, , stem cell therapy, , photothermal therapy, , and doping with bioactive nanoparticles. − Therefore, the research and development of hydrogels that can kill bacteria broadly and promote granulation tissue formation is of great clinical significance.…”

Section: Introductionmentioning

confidence: 99%

Electrospray Nano-Micro Composite Sodium Alginate Microspheres with Shape-Adaptive, Antibacterial, and Angiogenic Abilities for Infected Wound Healing

Song,

Li,

et al. 2024

ACS Appl. Mater. Interfaces

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Nonhealing infectious wounds, characterized by bacterial colonization, wound microenvironment destruction, and shape complexity, present an intractable problem in clinical practice. Inspired by LEGOs, building-block toys that can be assembled into desired shapes, we proposed the use of electrospray nano-micro composite sodium alginate (SA) microspheres with antibacterial and angiogenic properties to fill irregularly shaped wounds instantly. Specifically, porous poly(lactic-co-glycolic acid) (PLGA) microspheres (MSs) encapsulating basic fibroblast growth factor (bFGF) were produced by a water-in-oil-in-water double-emulsion method. Then, bFGF@MSs were blended with the SA solution containing ZIF-8 nanoparticles. The resultant solution was electrosprayed to obtain nano-micro composite microspheres (bFGF@MS/ZIF-8@ SAMSs). The composite MSs' size could be regulated by PLGA MS mass proportion and electrospray voltage. Moreover, bFGF, a potent angiogenic agent, and ZIF-8, bactericidal nanoparticles, were found to release from bFGF@MS/ZIF-8@SAMSs in a controlled and sustainable manner, which promoted cell proliferation, migration, and tube formation and killed bacteria. Through experimentation on rat models, bFGF@MS/ZIF-8@SAMSs were revealed to adapt to wound shapes and accelerate infected wound healing because of the synergistic effects of antibacterial and angiogenic abilities. In summation, this study developed a feasible approach to prepare bioactive nano-micro MSs as building blocks that can fill irregularly shaped infected wounds and improve healing.

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Recapitulation of growth factor-enriched microenvironment via BMP receptor activating hydrogel

Cited by 21 publications

References 53 publications

Rejuvenation of Mesenchymal Stem Cells to Ameliorate Skeletal Aging

Rejuvenation of Mesenchymal Stem Cells to Ameliorate Skeletal Aging

3D Bioprinting of Hyaline Articular Cartilage: Biopolymers, Hydrogels, and Bioinks

Electrospray Nano-Micro Composite Sodium Alginate Microspheres with Shape-Adaptive, Antibacterial, and Angiogenic Abilities for Infected Wound Healing

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