Having in mind its future extension for theoretical investigations related to charmed nuclei, we develop a relativistic formalism for the nonmesonic weak decay of single-Λ hypernuclei in the framework of the independent-particle shell model and with the dynamics represented by the (π, K) one-meson-exchange model. Numerical results for the one-nucleon-induced transition rates of 12 Λ C are presented and compared with those obtained in the analogous nonrelativistic calculation. There is satisfactory agreement between the two approaches, and the most noteworthy difference is that the ratio Γn/Γp is appreciably higher and closer to the experimental value in the relativistic calculation. Large discrepancies between ours and previous relativistic calculations are found, for which we do not encounter any fully satisfactory explanation. The most recent experimental data is well reproduced by our results. In summary, we have achieved our purpose to develop a reliable model for the relativistic calculation of the nonmesonic weak decay of Λ-hypernuclei, which can now be extended to evaluate similar processes in charmed nuclei.