Recent Advance of Liposome Nanoparticles for Nucleic Acid Therapy

Gao, Yongguang; Liu, Xinhua; Chen, Na; Yang, Xiaochun; Tang, Fang

doi:10.3390/pharmaceutics15010178

Cited by 28 publications

(13 citation statements)

References 148 publications

(143 reference statements)

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“…It is interesting to note that research on mRNA-LNP structures suggests that water, ionizable cationic lipids, and mRNA are all found in the core of LNPs. This prompts crucial queries concerning the mRNA’s potential protection against water [ 182 ]. For instance, it is not known if or how the LNP’s ionizable cationic lipids interact with the mRNA.…”

Section: Implications Of Changing Patterns Of Mutationsmentioning

confidence: 99%

“…To validate the suggested structure and comprehend the effects, further research must be performed. For instance, it has been determined that it is crucial to research the pH within the LNPs in connection to stability [ 171 , 182 ]. The exact type(s) of degradation that mRNA molecules go through in their final formulation should also be thoroughly examined, as should the possibility that strand integrity might be preserved by sequence change [ 182 ].…”

Section: Implications Of Changing Patterns Of Mutationsmentioning

confidence: 99%

“…For instance, it has been determined that it is crucial to research the pH within the LNPs in connection to stability [ 171 , 182 ]. The exact type(s) of degradation that mRNA molecules go through in their final formulation should also be thoroughly examined, as should the possibility that strand integrity might be preserved by sequence change [ 182 ]. While there are hints that certain folded configurations are more stable, this might also be connected to the analysis and improvement of the secondary and tertiary structure of mRNA [ 8 , 171 , 181 , 182 ].…”

Section: Implications Of Changing Patterns Of Mutationsmentioning

confidence: 99%

See 2 more Smart Citations

Variants of SARS-CoV-2: Influences on the Vaccines’ Effectiveness and Possible Strategies to Overcome Their Consequences

et al. 2023

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The immune response elicited by the current COVID-19 vaccinations declines with time, especially among the immunocompromised population. Furthermore, the emergence of novel SARS-CoV-2 variants, particularly the Omicron variant, has raised serious concerns about the efficacy of currently available vaccines in protecting the most vulnerable people. Several studies have reported that vaccinated people get breakthrough infections amid COVID-19 cases. So far, five variants of concern (VOCs) have been reported, resulting in successive waves of infection. These variants have shown a variable amount of resistance towards the neutralising antibodies (nAbs) elicited either through natural infection or the vaccination. The spike (S) protein, membrane (M) protein, and envelope (E) protein on the viral surface envelope and the N-nucleocapsid protein in the core of the ribonucleoprotein are the major structural vaccine target proteins against COVID-19. Among these targets, S Protein has been extensively exploited to generate effective vaccines against COVID-19. Hence, amid the emergence of novel variants of SARS-CoV-2, we have discussed their impact on currently available vaccines. We have also discussed the potential roles of S Protein in the development of novel vaccination approaches to contain the negative consequences of the variants’ emergence and acquisition of mutations in the S Protein of SARS-CoV-2. Moreover, the implications of SARS-CoV-2’s structural proteins were also discussed in terms of their variable potential to elicit an effective amount of immune response.

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Section: Implications Of Changing Patterns Of Mutationsmentioning

confidence: 99%

Section: Implications Of Changing Patterns Of Mutationsmentioning

confidence: 99%

Section: Implications Of Changing Patterns Of Mutationsmentioning

confidence: 99%

See 1 more Smart Citation

Variants of SARS-CoV-2: Influences on the Vaccines’ Effectiveness and Possible Strategies to Overcome Their Consequences

et al. 2023

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“…Within the perpetual conflict, the domain of nanotechnology has emerged as a promising prospect. Liposomes have become significant assets in the ongoing effort to improve cancer detection and therapy within the field of nanomaterials [ 1 , 2 , 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Liposome-Based Drug Delivery Systems in Cancer Research: An Analysis of Global Landscape Efforts and Achievements

Hamad,

Harb,

Bustanji

2024

Pharmaceutics

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Lipid-bilayer-based liposomes are gaining attention in scientific research for their versatile role in drug delivery. With their amphiphilic design, liposomes efficiently encapsulate and deliver drugs to targeted sites, offering controlled release. These artificial structures hold great promise in advancing cancer therapy methodologies. Bibliometric research analyzes systematic literary data statistically. This study used bibliometric indicators to examine, map, and evaluate the applications of liposomes in cancer therapy. A Scopus search was conducted to identify all English-language peer-reviewed scientific publications on the applications of liposomes in cancer therapy within the past twenty years. Bibliometric indicators were calculated using VOSviewer and Biblioshiny. We produced thematic, conceptual, and visualization charts. A total of 14,873 published documents were obtained. The procedure of keyword mapping has effectively identified the main areas of research concentration and prevailing trends within this specific field of study. The significant clusters discovered through theme and hotspot analyses encompassed many topics such as the use of multiple strategies in chemotherapy and different forms of cancer, the study of pharmacokinetics and nanomedicine, as well as the investigation of targeted drug delivery, cytotoxicity, and gene delivery. Liposomes were employed as drug delivery systems so as to selectively target cancer cells and improve the bioavailability of anticancer drugs. The work showcased the capacity to tailor these liposomes for accurate drug delivery by including potent anticancer medications. Our findings not only bring attention to the latest progress in utilizing liposomes for cancer treatment but also underscore the vital need for ongoing research, collaborative efforts, and the effective translation of these breakthroughs into tangible clinical applications, emphasizing the dynamic and evolving nature of cancer therapeutics.

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“…[1] In order to elicit an efficient response, these nucleic acid therapeutics (NATs) must not only withstand degradation by endogenous enzymes known as nucleases but must also be capable of reaching the desired organ and tissue where therapeutic action is required. Essential strategies have pioneered the clinical use of NATs, such as the development of chemically modified nucleic acids that are more resistant to degradation, [2] or encapsulation of these therapeutics within larger nanocarriers [3,4] to shield them from enzymes and allow for a more targeted biodistribution.…”

Section: Introductionmentioning

confidence: 99%

Impact of the Core Chemistry of Self‐Assembled Spherical Nucleic Acids on their In Vitro Fate

Faiad,

Laurent,

Prinzen

et al. 2023

Angew Chem Int Ed

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Nucleic acid therapeutics (NATs), such as mRNA, small interfering RNA or antisense oligonucleotides are extremely efficient tools to modulate gene expressions and tackle otherwise undruggable diseases. Spherical nucleic acids (SNAs) can efficiently deliver small NATs to cells while protecting their payload from nucleases, have improved biodistribution and muted immune activation. Self‐ assembled SNAs have emerged as nanostructures made from a single DNA‐polymer conjugate with similar favorable properties as well as small molecule encapsulation. However, because they maintain their structure by non‐covalent interactions, they might suffer from disassembly in biologically relevant conditions, especially with regards to their interaction with serum proteins. Here, we report a systematic study of the factors that govern the fate of self‐assembled SNAs. Varying the core chemistry and using stimuli‐responsive disulfide crosslinking, we show that extracellular stability upon binding with serum proteins is important for recognition by membrane receptors, triggering cellular uptake. At the same time, intracellular dissociation is required for efficient therapeutic release. Disulfide‐ crosslinked SNAs combine these two properties and result in efficient and non‐toxic unaided gene silencing therapeutics. We anticipate these investigations will help the translation of promising self‐ assembled structures towards in vivo gene silencing applications.

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Recent Advance of Liposome Nanoparticles for Nucleic Acid Therapy

Cited by 28 publications

References 148 publications

Variants of SARS-CoV-2: Influences on the Vaccines’ Effectiveness and Possible Strategies to Overcome Their Consequences

Variants of SARS-CoV-2: Influences on the Vaccines’ Effectiveness and Possible Strategies to Overcome Their Consequences

Liposome-Based Drug Delivery Systems in Cancer Research: An Analysis of Global Landscape Efforts and Achievements

Impact of the Core Chemistry of Self‐Assembled Spherical Nucleic Acids on their In Vitro Fate

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