Recent advancement in interventions for autism spectrum disorder: A review

Kalra, Ruchika; Gupta, Meena; Sharma, Priya

doi:10.1016/j.jnrt.2023.100068

Cited by 4 publications

(1 citation statement)

References 34 publications

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“…A range of therapeutic alternatives is accessible, including applied behavior analysis, social skills training, occupational therapy, physical therapy, sensory integration therapy, and the employment of assistive technologies ( 12 ). The treatments discussed in this context may be broadly classified into behavioral and communication techniques, dietary measures, medicine, and complementary and alternative therapies ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

Probiotics, prebiotics, and synbiotics for patients with autism spectrum disorder: a meta-analysis and umbrella review

Rahim,

Toguzbaeva,

Qasim

et al. 2023

Front. Nutr.

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Background and objectiveThe potential impact of gut health on general physical and mental well-being, particularly in relation to brain function, has led to a growing interest in the potential health advantages of prebiotics, probiotics, and synbiotics for the management of ASD. A comprehensive meta-analysis and systematic review was conducted in order to evaluate the effectiveness and protection of many drugs targeted at manipulating the microbiota in the treatment of ASD.MethodsThe present study employed a comprehensive examination of various electronic databases yielded a total of 3,393 records that were deemed possibly pertinent to the study. RCTs encompassed a total of 720 individuals between the ages of 2 and 17, as well as 112 adults and participants ranging from 5 to 55 years old, all of whom had received a diagnosis of ASD.ResultsOverall, 10 studies reported Autism-Related Behavioral Symptoms (ARBS). Regarding the enhancement of autism-related behavioral symptoms, there wasn’t a statistically significant difference between the intervention groups (combined standardized mean difference = −0.07, 95% confidence interval: −0.39 to 0.24, Z = 0.46, p = 0.65). We observed that in the patients with ASD treated with probiotic frontopolar’s power decreased significantly from baseline to endpoints in beta band (Baseline: 13.09 ± 3.46, vs. endpoint: 10.75 ± 2.42, p = 0.043, respectively) and gamma band (Baseline: 5.80 ± 2.42, vs. endpoint: 4.63 ± 1.39, p = 0.033, respectively). Among all tested biochemical measures, a significant negative correlation was found between frontopolar coherence in the gamma band and TNF-α (r = −0.30, p = 0.04).ConclusionThe existing body of research provides a comprehensive analysis of the developing evidence that indicates the potential of probiotics, prebiotics, and synbiotics as therapeutic therapies for ASD. Our findings revealed that those there was no significant effect of such therapy on autism-related behavioral symptoms, it has significant effect on the brain connectivity through frontopolar power in beta and gamma bands mediated by chemicals and cytokines, such as TNF-α. The psychobiotics showed no serious side-effects.

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Section: Introductionmentioning

confidence: 99%

Probiotics, prebiotics, and synbiotics for patients with autism spectrum disorder: a meta-analysis and umbrella review

Rahim,

Toguzbaeva,

Qasim

et al. 2023

Front. Nutr.

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Dietary interventions in autism: a critical appraisal and commentary on the findings of a systematic review

Woods,

Doherty,

Hill

2024

British Journal of Neuroscience Nursing

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An estimated 1% of the global population is believed to be autistic. Clinical focus is often on interventions that target social functioning, sensory processing and communication. Dietary interventions are often explored as a means of targeting these core symptoms. However, research findings are often inconclusive due to small sample sizes. This commentary article critically examines a meta-analysis focused on dietary interventions, including omega-3, vitamins and other supplements, in the management of autism. It evaluates the studies' findings and contextualises its implications for clinical nursing practice.

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Formation of cognitive processes in children with autism. Part I. Epigenetic mechanisms

Glotov,

Chernov,

Suchko

et al. 2024

Ross. vestn. perinatol. pediatr.

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Autism and autism spectrum disorders are neuropsychiatric diseases that begin to appear in children under 3 years. Over the past decade, the number of children with autism spectrum disorders has increased more than in 10-fold and continues to grow, accounting for 1–2 % of the world’s population. Currently, the diagnosis of autism spectrum disorders is based only on clinical and behavioral tests, and there are no biological and genetic markers that could contribute to the early detection of this disorder. The review, based on the analysis of modern literature data about epigenetic mechanisms which associated with autism, examines the influence of the DNA methylation profile in the formation of cognitive impairment and the possibility of using genes and their methylation status as diagnostic biomarkers in children with autism spectrum disorders. Literature data analysis shows that disorders of attention, speed of information processing, working memory, learning are based on genetic and epigenetic (methylation) changes in the expression of many genes: BDNF, CAPS2, CNTNAP2, GABRB3, FMR1, FOXP1, GTF2I, HSD11B2, MECP2, NF2, NGF, NR3C1, OXTR, PAK2, RELN, SLC6A4, UBE3A, etc. Most of these genes undergo hypermethylation, reducing the expression of its proteins, which impairs the development and formation of the nervous system in autism. In contrast, other genes are associated with methylation and oxidative stress are hypomethylated in autism spectrum disorders. Assessing the expression levels and methylation status of these genes can serve as genetic and epigenetic biomarkers for the differentiation and diagnosis of clinical symptoms, autism spectrum disorders severity, and facilitate the development of new treatments and rehabilitation procedures.

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Recent advancement in interventions for autism spectrum disorder: A review

Cited by 4 publications

References 34 publications

Probiotics, prebiotics, and synbiotics for patients with autism spectrum disorder: a meta-analysis and umbrella review

Probiotics, prebiotics, and synbiotics for patients with autism spectrum disorder: a meta-analysis and umbrella review

Dietary interventions in autism: a critical appraisal and commentary on the findings of a systematic review

Formation of cognitive processes in children with autism. Part I. Epigenetic mechanisms

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