Recent advancement in polymer/halloysite nanotube nanocomposites for biomedical applications

Haneef, Intan Najwa Humaira Mohamed; Shaffiar, Norhashimah; Buys, Yose Fachmi; Shaharuddin, Sharifah Imihezri Syed; Hamid, Abdul Malek Abdul; Widiyati, Khusnun

doi:10.1002/jbm.b.35105

Cited by 12 publications

(6 citation statements)

References 189 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This combination resulted in superior mechanical and functional properties, due to synergetic effects that also enhanced the interactions with biological species [ 242 ]. Regarding the addition of ceramic nanotubes, there is a recent trend of incorporating naturally occurring hollow nanotubes as a reinforcing agent in polymer composites, significantly improving mechanical properties such as stiffness and flexibility while maintaining good cytocompatibility and cell adhesion [ 245 , 246 ]. Among them, halloysite nanotubes (HNTs) are the most commonly reported ceramic nanotubes for this purpose, along with carbon nanotubes (CNTs), but these ones will be commented on later.…”

Section: Hybrid Hydrogel Compositesmentioning

confidence: 99%

“…The main reason is that HNTs are composed of hydrous aluminosilicate with a native tubular structure that can be easily obtained from natural resources. Along with its biocompatibility with human body, HNTs has been proposed as an interesting, valuable and low-cost alternative for bone tissue engineering applications [ 245 , 247 ]. Huang et al (2019) reported the successful incorporation of HNTs into a GelMA hydrogel by photopolymerization process and that HNTs addition increased the mechanical performance and the capability to support cell adhesion and proliferation of human dental pulp stem cells [ 246 ].…”

Section: Hybrid Hydrogel Compositesmentioning

confidence: 99%

See 1 more Smart Citation

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

View full text Add to dashboard Cite

Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced and solved. Hydrogels have been proposed as excellent candidates for these applications, as they have promising properties for the mentioned applications, including biocompatibility, biodegradability, great absorption capacity and tunable mechanical properties. However, depending on the material or the manufacturing method, the resulting hydrogel may not be up to the specific task for which it is designed, thus there are different approaches proposed to enhance hydrogel performance for the requirements of the application in question. The main purpose of this review article was to summarize the most recent trends of hydrogel technology, going through the most used polymeric materials and the most popular hydrogel synthesis methods in recent years, including different strategies of enhancing hydrogels’ properties, such as cross-linking and the manufacture of composite hydrogels. In addition, the secondary objective of this review was to briefly discuss other novel applications of hydrogels that have been proposed in the past few years which have drawn a lot of attention.

show abstract

Section: Hybrid Hydrogel Compositesmentioning

confidence: 99%

Section: Hybrid Hydrogel Compositesmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Nanotubes are composed of organic or inorganic atoms and can form single‐ or multi‐walled tubes with considerable internal volume. [ 149–151 ] Due to their extensive internal surface area and high aspect ratio, [ 152–154 ] carbon nanotubes (CNTs) with proper mechanical properties and biocompatibility are often used to prepare 3D‐printed functionalized bioscaffolds to enhance the scaffolds' mechanical properties and avoid mechanical damage due to fragility during use on. Liu et al.…”

Section: Incorporation Of Nanomaterials Into 3d‐printed Productsmentioning

confidence: 99%

Advanced Nanomaterials in Medical 3D Printing

Liu,

He,

Kuzmanović

et al. 2023

Small Methods

View full text Add to dashboard Cite

Abstract3D printing is now recognized as a significant tool for medical research and clinical practice, leading to the emergence of medical 3D printing technology. It is essential to improve the properties of 3D‐printed products to meet the demand for medical use. The core of generating qualified 3D printing products is to develop advanced materials and processes. Taking advantage of nanomaterials with tunable and distinct physical, chemical, and biological properties, integrating nanotechnology into 3D printing creates new opportunities for advancing medical 3D printing field. Recently, some attempts are made to improve medical 3D printing through nanotechnology, providing new insights into developing advanced medical 3D printing technology. With high‐resolution 3D printing technology, nano‐structures can be directly fabricated for medical applications. Incorporating nanomaterials into the 3D printing material system can improve the properties of the 3D‐printed medical products. At the same time, nanomaterials can be used to expand novel medical 3D printing technologies. This review introduced the strategies and progresses of improving medical 3D printing through nanotechnology and discussed challenges in clinical translation.

show abstract

“…[7][8][9] Besides MWCNTs, halloysite nanotubes (HNTs) have also been used as materials for biomedical purposes, such as drug delivery, 10 disease therapy, 11 and tissue scaffolds. 12 Although HNTs have been considered as relatively biocompatible NMs for biomedical uses, 13,14 their potential toxicity should still be carefully evaluated.…”

mentioning

confidence: 99%

“…19,20 For HNTs, they are derived from natural clay mineral and have been considered to be highly biocompatible. 13,14 However, recent studies still reported that repeated exposure to HNTs induced injury to mouse lungs 21 and livers 22 in vivo. We reported recently that intravenous exposure to HNTs impaired NO signaling pathways in mouse aortas, although the effect of HNTs was weaker than MWCNTs.…”

mentioning

confidence: 99%

Effects of multi‐walled carbon nanotubes and halloysite nanotubes on plasma lipid profiles and autophagic lipolysis pathways in mouse aortas and hearts

Cheng,

Zhang,

Wang

et al. 2024

Environmental Toxicology

View full text Add to dashboard Cite

Multi‐walled carbon nanotubes (MWCNTs) and halloysite nanotubes (HNTs) are widely used tubular‐structured nanomaterials (NMs), but their cardiovascular effects are not clear. This study compared the effects of MWCNTs and HNTs on lipid profiles in mouse plasma and gene expression profiles in aortas and hearts. Mice were intravenously injected with 50 μg NMs, once a day, for 5 days. Then, the plasma was collected for lipidomics analysis, and aortas and hearts were collected for RNA‐sequencing analysis. While MWCNTs or HNTs did not induce obvious pathological changes in aortas or hearts, the lipid profiles in mouse plasma were altered. Further analysis revealed that MWCNTs more effectively upregulated sphingolipids and sterol lipids, whereas HNTs more effectively upregulated glycerophospholipids and fatty acyls. Consistently, RNA‐sequencing data indicated that MWCNTs and HNTs altered signaling pathways related with lipid synthesis and metabolism, as well as those related with endoplasmic reticulum, lysosomes and autophagy, more significantly in aortas than in hearts. We further verified the changes of proteins involved in autophagic lipolysis, that MWCNTs were more effectively to suppress the autophagic biomarker LC3, whereas HNTs were more effectively to affect lipid metabolism proteins. These results may provide novel understanding about the influences of MWCNTs and HNTs on lipid profiles and lipid signaling pathways in cardiovascular systems. Importantly, previous studies considered HNTs as biocompatible materials, but the results from this study suggested that both MWCNTs and HNTs were capable to affect lipid profiles and autophagic lipolysis pathways in cardiovascular systems, although their exact influences were different.

show abstract

Recent advancement in polymer/halloysite nanotube nanocomposites for biomedical applications

Cited by 12 publications

References 189 publications

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Advanced Nanomaterials in Medical 3D Printing

Effects of multi‐walled carbon nanotubes and halloysite nanotubes on plasma lipid profiles and autophagic lipolysis pathways in mouse aortas and hearts

Contact Info

Product

Resources

About