"Recent Advancement on Experimentally Proven Phytopharmaceuticals that Inhibit Vasculature Development, Cancer Cell Invasion and Metastasis"

Abstract

In modern medical science, targeting the tumour vasculature instead of the tumour cells is of great interest for the management of tumour associated complications. In context to that, the review was planned to explore the mechanisms of pathological angiogenesis responsible for cancer cell invasion and metastasis. The experimentally proven phytopharmaceuticals having a significant effect to inhibit vasculature development are represented schematically. The scientific literature from authenticated databases (Scopus, PubMed, etc.) search was conducted with emphasis on the previous fifteen years, combining the keywords as selected. Mechanisms of pathological angiogenesis responsible for cancer cell invasion and metastasis have been explained with possible regulatory protein involvement. A total of 97 experimentally proven plant molecules, studied in this review, including 69 plant species among 40 plant families, are summarized in a schematic way.Hopefully, this review will facilitate the biomedical scientists in setting up the appropriate research questions around the molecular targets discussed in this review for the management of cancer cell invasion and migration and for further proof-ofconcept validation studies for exploring such phytopharmaceuticals. neovascularization [3]. In 1971, a hypothesis by Judah Folkman