Recent Advancements in 3D Printing of Polysaccharide Hydrogels in Cartilage Tissue Engineering

Naranda, Jakob; Bračič, Matej; Vogrin, Matjaž; Maver, Uroš

doi:10.3390/ma14143977

Cited by 40 publications

(26 citation statements)

References 127 publications

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“…Alginate is also one of the most commonly used biomolecules in 3D bioprinting due to its compatibility with extrusion and inkjet printing processes [ 310 ], and its ability to maintain cell growth due to its similar properties to natural ECM [ 85 , 309 ]. As noted above, the ability of alginate hydrogels to bear weight and maintain their shape is limited, however, and so they are typically reinforced with natural and/or synthetic molecules such as fibrin or fibrinogen, nanocellulose, gelatin and nano-hydroxyapatite (n-HAP) to improve their structure [ 311 ].…”

Section: Polysaccharide-based Biomaterialsmentioning

confidence: 99%

Nature-Based Biomaterials and Their Application in Biomedicine

et al. 2021

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Natural polymers, based on proteins or polysaccharides, have attracted increasing interest in recent years due to their broad potential uses in biomedicine. The chemical stability, structural versatility, biocompatibility and high availability of these materials lend them to diverse applications in areas such as tissue engineering, drug delivery and wound healing. Biomaterials purified from animal or plant sources have also been engineered to improve their structural properties or promote interactions with surrounding cells and tissues for improved in vivo performance, leading to novel applications as implantable devices, in controlled drug release and as surface coatings. This review describes biomaterials derived from and inspired by natural proteins and polysaccharides and highlights their promise across diverse biomedical fields. We outline current therapeutic applications of these nature-based materials and consider expected future developments in identifying and utilising innovative biomaterials in new biomedical applications.

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Section: Polysaccharide-based Biomaterialsmentioning

confidence: 99%

Nature-Based Biomaterials and Their Application in Biomedicine

et al. 2021

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“…In terms of the biological functions, the main concerns focus on supporting the proliferation and differentiation of the cells and creating a bioactive environment to mimic the natural extracellular matrix (ECM). [ 30 ] In addition, a suitable crosslinking process is also quite essential to avoid adversely affecting the vitality of the cells. To solve these issues, many efforts have been made in modifying hydrogel bioinks.…”

Section: Design Principle Of the Functional Bioinks For 3d Bioprintin...mentioning

confidence: 99%

Inorganic biomaterials‐based bioinks for three‐dimensional bioprinting of regenerative scaffolds

Chen

2022

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The application of inorganic biomaterials in regenerative medicine is increasingly expanded. Taking advantages of attractive properties of the inorganic biomaterials, sorts of functional bioinks have been developed based on inorganic biomaterials and were applied to construct inorganic/organic/cell‐laden systems for tissue regeneration via 3D bioprinting technology. In this review, we aim to summarize the existing inorganic biomaterials‐based bioinks (referred to as “inorganic‐bioinks”) for 3D bioprinting regenerative scaffolds. We introduce the recently developed inorganic‐bioinks from the perspective of the function of bioinks, and especially highlight the incorporation of inorganic biomaterials improving the printability, mechanical strength, and bioactivity of the bioinks for different tissue regeneration. Subsequently, the current applications of the inorganic‐bioinks in constructing 3D cell‐laden scaffolds for tissue regeneration are presented. Finally, challenges and prospects for the inorganic biomaterials‐based bioprinting strategy are discussed.

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“…Another biocompatible polymer, commonly employed in regenerative medicine, is methylcellulose (MC), thanks to its high hydrophilicity, which has a key importance for delivering nutrients to cells [ 45 ]. Differently from cellulose, MC is soluble in water solutions, due to the presence of methoxy groups within MC [ 46 ].…”

Section: Naturally-derived Bioinks For 3d Bioprinting Of Cartilage Ti...mentioning

confidence: 99%

Three-Dimensional Bioprinting for Cartilage Tissue Engineering: Insights into Naturally-Derived Bioinks from Land and Marine Sources

Szychlinska

Bucchieri

Fucarino

et al. 2022

JFB

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In regenerative medicine and tissue engineering, the possibility to: (I) customize the shape and size of scaffolds, (II) develop highly mimicked tissues with a precise digital control, (III) manufacture complex structures and (IV) reduce the wastes related to the production process, are the main advantages of additive manufacturing technologies such as three-dimensional (3D) bioprinting. Specifically, this technique, which uses suitable hydrogel-based bioinks, enriched with cells and/or growth factors, has received significant consideration, especially in cartilage tissue engineering (CTE). In this field of interest, it may allow mimicking the complex native zonal hyaline cartilage organization by further enhancing its biological cues. However, there are still some limitations that need to be overcome before 3D bioprinting may be globally used for scaffolds’ development and their clinical translation. One of them is represented by the poor availability of appropriate, biocompatible and eco-friendly biomaterials, which should present a series of specific requirements to be used and transformed into a proper bioink for CTE. In this scenario, considering that, nowadays, the environmental decline is of the highest concerns worldwide, exploring naturally-derived hydrogels has attracted outstanding attention throughout the scientific community. For this reason, a comprehensive review of the naturally-derived hydrogels, commonly employed as bioinks in CTE, was carried out. In particular, the current state of art regarding eco-friendly and natural bioinks’ development for CTE was explored. Overall, this paper gives an overview of 3D bioprinting for CTE to guide future research towards the development of more reliable, customized, eco-friendly and innovative strategies for CTE.

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Recent Advancements in 3D Printing of Polysaccharide Hydrogels in Cartilage Tissue Engineering

Cited by 40 publications

References 127 publications

Nature-Based Biomaterials and Their Application in Biomedicine

Nature-Based Biomaterials and Their Application in Biomedicine

Inorganic biomaterials‐based bioinks for three‐dimensional bioprinting of regenerative scaffolds

Three-Dimensional Bioprinting for Cartilage Tissue Engineering: Insights into Naturally-Derived Bioinks from Land and Marine Sources

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