Recent advancements in astaxanthin production from microalgae: A review

Patel, Anil Kumar; Tambat, Vaibhav Sunil; Chen, Chiu-Wen; Chauhan, Ajeet Singh; Kumar, Prashant; Vadrale, Akash Pralhad; Huang, Chun-Yung; Dong, Cheng–Di; Singhania, Reeta Rani

doi:10.1016/j.biortech.2022.128030

Cited by 81 publications

(26 citation statements)

References 131 publications

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“…In addition, petrochemical-refined xanthophyll is not allowed to be used in food and pharmaceutical products. The yield of xanthophyll extracted from plants or algae is too low to meet industrial needs [ 11 , 12 ]. In recent decades, metabolic engineering based on model microbes for the production of nature bioactivity compounds has experienced extensive development [ 13 , 14 , 15 ], which brings a promising potential for the industrial synthesis of natural xanthophyll.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Engineering of Model Microorganisms for the Production of Xanthophyll

et al. 2023

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Xanthophyll is an oxidated version of carotenoid. It presents significant value to the pharmaceutical, food, and cosmetic industries due to its specific antioxidant activity and variety of colors. Chemical processing and conventional extraction from natural organisms are still the main sources of xanthophyll. However, the current industrial production model can no longer meet the demand for human health care, reducing petrochemical energy consumption and green sustainable development. With the swift development of genetic metabolic engineering, xanthophyll synthesis by the metabolic engineering of model microorganisms shows great application potential. At present, compared to carotenes such as lycopene and β-carotene, xanthophyll has a relatively low production in engineering microorganisms due to its stronger inherent antioxidation, relatively high polarity, and longer metabolic pathway. This review comprehensively summarized the progress in xanthophyll synthesis by the metabolic engineering of model microorganisms, described strategies to improve xanthophyll production in detail, and proposed the current challenges and future efforts needed to build commercialized xanthophyll-producing microorganisms.

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Section: Introductionmentioning

confidence: 99%

Metabolic Engineering of Model Microorganisms for the Production of Xanthophyll

et al. 2023

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“…And several kinds of pigments derived from microorganisms have been developed as industry products, including prodigiosin ( Ramesh et al, 2020 ), phycocyanin ( Ashaolu et al, 2021 ), ankaflavin ( Hsu et al, 2011 ; Dufossé, 2017 ), astaxanthin ( Patel et al, 2022 ), β -carotene ( Lopes et al, 2009 ; Dufossé, 2017 ), monascorubramin ( Dufossé, 2018 ), riboflavin ( De Faria et al, 2022 ), rubropunctatin ( Zheng et al, 2010 ), anthraquinones ( Venil and Lakshmanaperumalsamy, 2009 ). These food grade pigments obtained from microbial sources can also have health benefits as anti-cancer, anti-microbial and antioxidant, etc.…”

Section: Introductionmentioning

confidence: 99%

Pigments of aminophenoxazinones and viridomycins produced by termite-associated Streptomyces tanashiensis BYF-112

Zhang

Zhou

et al. 2023

Front. Microbiol.

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Termite-associated Streptomyces tanashiensis BYF-112 was found as a potential source for yellow and green pigments, which were stable under the tested temperature, light and metal ions. Eight metabolites (1–8), including four new natural yellow pigments aminophenoxazinones (1–4), and two rarely iron dependent green pigments viridomycin A and F (9–10) were isolated from BYF-112 cultured in YMS and YMS treated with FeSO4, respectively. The metabolites 2–4 displayed a significant safety performance on the normal liver cell line L-02, while the metabolite 1 showed weak cytotoxicity against the L-02 and several cancer cells. Especially, in the filter paper disc tests, the compound 1 possessed strong antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) with the zone of inhibition (ZOI) of 15.3 mm, which was equal to that of referenced levofloxacin (ZOI = 15.2 mm). And the metabolite 1 also showed moderate antibacterial activities against Micrococcus teragenus and S. aureus, with the ZOI values of 15.3 and 17.2 mm. In addition, by the minimum inhibitory concentration (MIC) assay, the compound 1 displayed potential antibacterial activities against M. teragenus, S. aureus and MRSA, with the MIC values of 12.5, 12.5, and 25.0 μg/ml, respectively. The present results indicate that BYF-112 may be a promising source for safe and bioactive pigments, which can be used for further development and industrial applications.

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“…Furthermore, the magnetic nanoparticles can be recovered and reused easily after the harvesting process, reducing the overall cost of the process and minimizing waste generation. The microalgal magnetic harvesting process is a promising method for harvesting microalgae because it is efficient, low-cost, scalable, sustainable, and environmentally friendly. ,,, Despite these advantages, few studies have examined the integration of microalgal harvesting, cell wall disruption, and extraction processes, all of which may be assisted by magnetic nanoparticles. In addition, little is known regarding the effects of magnetic nanoparticles on the overall efficiency of the combined harvesting and extraction processes of the microalgal biorefinery because of the lack of systematic investigation to understand the unique characteristics of the integrated processes.…”

Section: Introductionmentioning

confidence: 99%

“…19,20 Microalgae have attracted significant interest in the pharmaceutical, nutraceutical, aquaculture, and biofuel industries as sustainable sources of value-added chemicals. 21,22 Microalgal biorefineries are the processes engineered for the harvesting and utilization of bioactive proteins, carbohydrates, lipids, pigments, and other metabolites produced from microalgae. 23 The processes comprise multiple stages: cultivation, harvesting, extraction, and recovery.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Two-Dimensional Fe₃O₄ Nanodisks and Nanosheets Transformed from α-Fe₂O₃ Analogues and Their Applications in Magnetic Field-Assisted Microalgal Harvesting Biorefinery Processes

Jeong,

Kim,

Sathiyavahisan

et al. 2023

ACS Sustainable Chem. Eng.

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Two-dimensional Fe 3 O 4 nanodisks (NDs) and nanosheets (NSs) were prepared from the thermal transformation of α-Fe 2 O 3 NDs and NSs, respectively. As a shape-controlling additive, the Al 3+ concentration controlled their sizes and disk-or sheet-like morphologies. Analyses of α-Fe 2 O 3 and Fe 3 O 4 NDs and NSs reveal anisotropic nanoarchitectures of highly crystalline hematite and magnetite domains, respectively. Magnetic hysteresis showed that α-Fe 2 O 3 NDs and NSs were weak superparamagnetic, while Fe 3 O 4 NDs and NSs were soft ferrimagnetic. The magnetic harvesting of microalga Haematococcus pluvialis (H. pluvialis) using Fe 3 O 4 NDs and NSs was demonstrated, resulting in a harvesting efficiency (HE) of >∼95% at less than 1 min of incubation. The efficient extraction of astaxanthin (ATX) from H. pluvialis was demonstrated through the laceration of the cell wall by Fe 3 O 4 NDs and NSs under mild ultrasonications. ATX extraction efficiencies (EEs) of up to ∼83% with minimal cellular damage under <10 min of mild ultrasonication were obtained using Fe 3 O 4 NSs. The potential recycling feasibility of Fe 3 O 4 NDs and NSs was assessed by measuring their HE and EE after five magnetic recovery and regeneration cycles using scrubbing procedures. This study revealed a synergistic enhancement of the HE and EE by integrating magnetic nanomaterial-based harvesting and extraction, offering novel process solutions for highly efficient microalgal biorefineries.

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Recent advancements in astaxanthin production from microalgae: A review

Cited by 81 publications

References 131 publications

Metabolic Engineering of Model Microorganisms for the Production of Xanthophyll

Metabolic Engineering of Model Microorganisms for the Production of Xanthophyll

Pigments of aminophenoxazinones and viridomycins produced by termite-associated Streptomyces tanashiensis BYF-112

Preparation of Two-Dimensional Fe₃O₄ Nanodisks and Nanosheets Transformed from α-Fe₂O₃ Analogues and Their Applications in Magnetic Field-Assisted Microalgal Harvesting Biorefinery Processes

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Recent advancements in astaxanthin production from microalgae: A review

Cited by 81 publications

References 131 publications

Metabolic Engineering of Model Microorganisms for the Production of Xanthophyll

Metabolic Engineering of Model Microorganisms for the Production of Xanthophyll

Pigments of aminophenoxazinones and viridomycins produced by termite-associated Streptomyces tanashiensis BYF-112

Preparation of Two-Dimensional Fe3O4 Nanodisks and Nanosheets Transformed from α-Fe2O3 Analogues and Their Applications in Magnetic Field-Assisted Microalgal Harvesting Biorefinery Processes

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Preparation of Two-Dimensional Fe₃O₄ Nanodisks and Nanosheets Transformed from α-Fe₂O₃ Analogues and Their Applications in Magnetic Field-Assisted Microalgal Harvesting Biorefinery Processes