Recent advancements in biopolymer and metal nanoparticle-based materials in diabetic wound healing management

Vijayakumar, Veena; Samal, Sushanta K.; Mohanty, Smita; Nayak, Sanjay K.

doi:10.1016/j.ijbiomac.2018.10.120

Cited by 311 publications

(175 citation statements)

References 133 publications

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“…Diabetes mellitus is known as a systemic disease including neuropathy, vasculopathy and nephropathy. Furthermore, DM can cause delay in wound healing (Vijayakumar, Samal, Mohanty, & Nayak, ). Myofibroblasts have an important role during wound healing and collagen production.…”

Section: Discussionmentioning

confidence: 99%

Is high levels of vitamin D a new risk factor for Peyronie's disease?

et al. 2019

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The aim of this study is to investigate whether serum vitamin D level predicts the risk of Peyronie's disease. Calcium and inflammatory cytokines play an important role during fibrocalcification of the plaques in Peyronie's Disease. TGF-β1 is one of the most fibrogenic cytokines. Increasing serum vitamin D levels is considered that induce expression of TGF-β1. Serum vitamin D levels and TGF-β1 are related with calcifications of some soft tissues in previous studies. One hundred and three Peyronie patients and 162 healthy volunteers were included in the study. In both groups, demographic data, medical history, physical examination and erectile capacity were recorded. Serum 25-hydroxyvitamin D, total cholesterol, low-density lipoprotein, high-density lipoprotein, triglyceride and testosterone levels were measured. The mean level of serum 25 (OH) D was significantly higher in men with Peyronie's disease compared with the controls (32.6 ± 7.9 ng/ml vs. 18.5 ± 6.6 ng/ml respectively. p < 0.001). There is a relationship between Peyronie's disease and high serum vitamin D levels. Also, increased low-density lipoprotein and total cholesterol levels, diabetes mellitus, and cardiovascular diseases were associated with Peyronie's disease. K E Y W O R D Spenile curvature, Peyronie's disease, plaque, vitamin D (Bollineni & Reddi, 1993). In addition, the severity of PD may correlate with DM has been shown (Kendirci, Trost, Sikka, & Hellstrom, 2007). In our study, 6.2% of patients had DM in control group and 26.2% of patients had DM in PD group (p < 0.001).Aetiologic impact of smoking is unclear in PD. Smoking has been shown as a PD risk factor in some studies. A retrospective case-control study showed that smoking was associated with PD (Bjekic et al., 2006). An another comparative clinical study showed that smoking was statistically higher in patients with PD than healthy population (Pavone et al., 2015). However, we did not find a significant relationship between smoking and PD (p = 0.375). Similarly, the impact of alcohol using is uncertain, although there are some studies showing that alcohol consumption is a risk factor for PD. Bjekic et al. found that alcohol consumption was related with PD (Bjekic et al., 2006).However, in the present study our results do not support this association (p = 0.468).Cholesterol is known a precursor of steroid hormones and has important roles in body metabolism. Hypercholesterolaemia and increased LDL levels are related with hyperlipidemia. Hyperlipidaemia is well known as a risk factor for vascular diseases. CVD is considered to lead of vascular weakness and facilitate the vascular damages during sexual intercourse. Therefore, hyperlipidaemia and CVD are risk factors for PD according to previous studies (Bjekic et al., 2006;Kadioglu et al., 2002;Muralidhar, Kumar, Sharma, Sharma, & Mandai, 1997). In our study, we found that increased CVD rates and high LDL/ total cholesterol levels were associated with PD.Our study has several limitations. Firstly, serum calcium and cavernosal TGF-β1 levels...

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Section: Discussionmentioning

confidence: 99%

Is high levels of vitamin D a new risk factor for Peyronie's disease?

et al. 2019

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“…In this regard, a combination of antibacterial nanoparticles such as silver, gold, or copper nanoparticles with polymeric matrix could potentially suppress bacterial propagation and similarly fastens the healing process of a wound and mitigate the diabetes mellitus-based foot ulcer. 264 More examples on this nanoparticle are available in Table 1. [265][266][267][268][269]…”

Section: Metal Nanoparticle (Mn)mentioning

confidence: 99%

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Rahman

Othman

Hammadi

et al. 2020

IJN

156

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Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made successfully on the development of novel drug delivery systems for encapsulation of plant active metabolites including organic, inorganic and hybrid nanoparticles. The advanced formulas are confirmed to have extraordinary benefits over conventional and previously used systems in the manner of solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, and both physical and chemical degradation. The current review highlights the development of novel nanocarrier for plant active compounds, their method of preparation, type of active ingredients, and their biomedical applications.

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“…Different sources, like plant cell walls, cotton, microcrystalline cellulose, algae, animals, and bacteria, have been used to obtain CNCs [81,129]. Like CNFs, the geometric dimensions and the final properties of the CNCs are directly dependent on the cellulosic source, the post-or pretreatments, and the subsequent preparation and processing conditions [130]. CNCs are characterized by their biocompatibility, biodegradability, high level of crystallinity (54-88%), excellent stability and mechanical performance (high strength as well as modulus), exceptional optical properties, and flexible surface chemistry [123,131].…”

Section: Nanocellulosementioning

confidence: 99%

“…NPs can act as delivery vehicles, protecting and releasing active compounds locally, or by intervening in specific functions via their intrinsic properties [6]. Their antibacterial potential results from their production of reactive oxygen species and their capability to bind and disrupt DNA or RNA functions that obstruct microbial reproduction [130]. By associating NPs with a textile or polymeric matrix synergistic actions can be revealed, generating a new formulation of active dressings [6,148].…”

Section: Nanoparticles (Nps)mentioning

confidence: 99%

“…By associating NPs with a textile or polymeric matrix synergistic actions can be revealed, generating a new formulation of active dressings [6,148]. The NPs with antimicrobial activity that have been explored in combination with dressings are the bioactive glass, gold, copper, cerium, zinc oxide, carbon-based, titanium dioxide, gallium, nitric oxide, and AgNPs [130]. These display bacteriostatic and bactericidal capacity, reduced in vivo toxicity (at low concentrations), are low cost, and possess physical, chemical, and biological features that trigger complex biological responses [196].…”

Section: Nanoparticles (Nps)mentioning

confidence: 99%

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Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing

et al. 2020

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Wound healing requires careful, directed, and effective therapies to prevent infections and accelerate tissue regeneration. In light of these demands, active biomolecules with antibacterial properties and/or healing capacities have been functionalized onto nanostructured polymeric dressings and their synergistic effect examined. In this work, various antibiotics, nanoparticles, and natural extract-derived products that were used in association with electrospun nanocomposites containing cellulose, cellulose acetate and different types of nanocellulose (cellulose nanocrystals, cellulose nanofibrils, and bacterial cellulose) have been reviewed. Renewable, natural-origin compounds are gaining more relevance each day as potential alternatives to synthetic materials, since the former undesirable footprints in biomedicine, the environment, and the ecosystems are reaching concerning levels. Therefore, cellulose and its derivatives have been the object of numerous biomedical studies, in which their biocompatibility, biodegradability, and, most importantly, sustainability and abundance, have been determinant. A complete overview of the recently produced cellulose-containing nanofibrous meshes for wound healing applications was provided. Moreover, the current challenges that are faced by cellulose acetate- and nanocellulose-containing wound dressing formulations, processed by electrospinning, were also enumerated.

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Recent advancements in biopolymer and metal nanoparticle-based materials in diabetic wound healing management

Cited by 311 publications

References 133 publications

Is high levels of vitamin D a new risk factor for Peyronie's disease?

Is high levels of vitamin D a new risk factor for Peyronie's disease?

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing

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