Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications

Kulkarni, Deepak; Damiri, Fouad; Rojekar, Satish; Zehravi, Mehrukh; Ramproshad, Sarker; Dhoke, Dipali M.; Musale, Shubham; Mulani, Ashiya A.; Modak, Pranav; Paradhi, Roshani; Vitore, Jyotsna; Rahman, Habibur; Berrada, Mohamed Saleh; Giram, Prabhanjan S.; Cavalu, Simona

doi:10.3390/pharmaceutics14051097

Cited by 60 publications

(23 citation statements)

References 237 publications

(260 reference statements)

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“…By increasing skin penetration of photosensitizers, it could boost the efficacy of PDT, lead to a reduction in dose and a decrease in potential side effects. 16 …”

Section: Discussionmentioning

confidence: 99%

Photodynamic therapy for the treatment of primary cutaneous B-cell marginal zone lymphoma: A series of 4 patients

Toulemonde¹,

Faiz²,

Dubois³

et al. 2023

JAAD Case Reports

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“…By increasing skin penetration of photosensitizers, it could boost the efficacy of PDT, lead to a reduction in dose and a decrease in potential side effects. 16 …”

Section: Discussionmentioning

confidence: 99%

Photodynamic therapy for the treatment of primary cutaneous B-cell marginal zone lymphoma: A series of 4 patients

Toulemonde¹,

Faiz²,

Dubois³

et al. 2023

JAAD Case Reports

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“…Many research studies have shown that graphene oxide (GO) and reduced graphene oxide (rGO) have promising adsorption capabilities in the cleanup of heavy metal ions, organic pollutants, and pharmaceutical toxins [ 31 , 32 , 33 ]. Gupta et al demonstrated that rGO possesses an excellent surface area and a significant number of voids, allowing it to effectively remove malachite green dye from wastewater [ 34 , 35 ].…”

Section: Nanomaterials In Wastewater Treatmentmentioning

confidence: 99%

Recent Advances in Adsorptive Nanocomposite Membranes for Heavy Metals Ion Removal from Contaminated Water: A Comprehensive Review

Damiri

Andra²,

Kommineni

et al. 2022

Materials

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Water contamination is one of the most urgent concerns confronting the world today. Heavy metal poisoning of aquatic systems has piqued the interest of various researchers due to the high toxicity and carcinogenic consequences it has on living organisms. Due to their exceptional attributes such as strong reactivity, huge surface area, and outstanding mechanical properties, nanomaterials are being produced and employed in water treatment. In this review, recent advances in the use of nanomaterials in nanoadsorptive membrane systems for wastewater treatment and heavy metal removal are extensively discussed. These materials include carbon-based nanostructures, metal nanoparticles, metal oxide nanoparticles, nanocomposites, and layered double hydroxide-based compounds. Furthermore, the relevant properties of the nanostructures and the implications on their performance for water treatment and contamination removal are highlighted. The hydrophilicity, pore size, skin thickness, porosity, and surface roughness of these nanostructures can help the water permeability of the nanoadsorptive membrane. Other properties such as surface charge modification and mechanical strength can improve the metal adsorption effectiveness of nanoadsorptive membranes during wastewater treatment. Various nanocomposite membrane fabrication techniques are also reviewed. This study is important because it gives important information on the roles of nanomaterials and nanostructures in heavy metal removal and wastewater treatment.

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“…The transdermal drug delivery system [ 8 ], one of the driving areas of drug delivery research, offers significant advantages over oral and injectable drug delivery [ 9 , 10 ]. As a third-generation drug delivery system [ 11 ], MNs can deliver drugs to the dermal area of the skin [ 12 , 13 , 14 ], which provides a new idea for transdermal drug delivery [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Glucose-Responsive Silk Fibroin Microneedles for Transdermal Delivery of Insulin

et al. 2023

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Microneedles (MNs) have attracted great interest as a drug delivery alternative to subcutaneous injections for treating diabetes mellitus. We report MNs prepared from polylysine-modified cationized silk fibroin (SF) for responsive transdermal insulin delivery. Scanning electron microscopy analysis of MNs’ appearance and morphology revealed that the MNs were well arranged and formed an array with 0.5 mm pitch, and the length of single MNs is approximately 430 μm. The average breaking force of an MN is above 1.25 N, which guarantees that it can pierce the skin quickly and reach the dermis. Cationized SF MNs are pH-responsive. MNs dissolution rate increases as pH decreases and the rate of insulin release are accelerated. The swelling rate reached 223% at pH = 4, while only 172% at pH = 9. After adding glucose oxidase, cationized SF MNs are glucose-responsive. As the glucose concentration increases, the pH inside the MNs decreases, the MNs’ pore size increases, and the insulin release rate accelerates. In vivo experiments demonstrated that in normal Sprague Dawley (SD) rats, the amount of insulin released within the SF MNs was significantly smaller than that in diabetic rats. Before feeding, the blood glucose (BG) of diabetic rats in the injection group decreased rapidly to 6.9 mmol/L, and the diabetic rats in the patch group gradually reduced to 11.7 mmol/L. After feeding, the BG of diabetic rats in the injection group increased rapidly to 33.1 mmol/L and decreased slowly, while the diabetic rats in the patch group increased first to 21.7 mmol/L and then decreased to 15.3 mmol/L at 6 h. This demonstrated that the insulin inside the microneedle was released as the blood glucose concentration increased. Cationized SF MNs are expected to replace subcutaneous injections of insulin as a new modality for diabetes treatment.

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Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications

Cited by 60 publications

References 237 publications

Photodynamic therapy for the treatment of primary cutaneous B-cell marginal zone lymphoma: A series of 4 patients

Photodynamic therapy for the treatment of primary cutaneous B-cell marginal zone lymphoma: A series of 4 patients

Recent Advances in Adsorptive Nanocomposite Membranes for Heavy Metals Ion Removal from Contaminated Water: A Comprehensive Review

Glucose-Responsive Silk Fibroin Microneedles for Transdermal Delivery of Insulin

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