Recent advances and applications in QDs-based sensors

Ma, Qiang; Su, Xingguang

doi:10.1039/c1an15741h

Cited by 123 publications

(55 citation statements)

References 93 publications

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“…Most importantly, ECL biosensors have lots of advantages, including high sensitivity, low backgound, ease of control and simple equipments (Zheng et al, 2001;Chovin et al, 2004). Semiconductor quantum dots (QDs) have attracted great attention in the past decade, due to their remarkable optoelectronic properties, such as narrow, symmetrical and size-tunable emission spectrum, broad excitation spectrum, large Stokes shift, high photo-bleaching threshold and good chemical stability (Hanif et al, 2002;Ma and Su, 2011). Uptil now, numerous reviews about QDs-based ECL have been published Huang et al, 2011;Li et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

A novel signal-off electrochemiluminescence biosensor for the determination of glucose based on double nanoparticles

Liu

et al. 2015

Biosensors and Bioelectronics

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Section: Introductionmentioning

confidence: 99%

A novel signal-off electrochemiluminescence biosensor for the determination of glucose based on double nanoparticles

Liu

et al. 2015

Biosensors and Bioelectronics

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“…Quantum dots (QDs) possess unique physical and chemical properties, including broad absorption, narrow emission, and high quantum yield [1][2][3][4]. Because of these properties, combined with their excellent biological binding capabilities, QDs have been considered as viable alternatives for organic photoluminescence (PL) probes in immunoassay, genomic analysis, and drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Fe3O4@C@CNC multifunctional magnetic core/shell nanoparticles and their application in a signal-type flow-injection photoluminescence immunosensor

Chu

et al. 2013

Anal Bioanal Chem

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We describe here the preparation of carbon-coated Fe3O4 magnetic nanoparticles that were further fabricated into multifunctional core/shell nanoparticles (Fe3O4@C@CNCs) through a layer-by-layer self-assembly process of carbon nanocrystals (CNCs). The nanoparticles were applied in a photoluminescence (PL) immunosensor to detect the carcinoembryonic antigen (CEA), and CEA primary antibody was immobilized onto the surface of the nanoparticles. In addition, CEA secondary antibody and glucose oxidase were covalently bonded to silica nanoparticles. After stepwise immunoreactions, the immunoreagent was injected into the PL cell using a flow-injection PL system. When glucose was injected, hydrogen peroxide was obtained because of glucose oxidase catalysis and quenched the PL of the Fe3O4@C@CNC nanoparticles. The here proposed PL immunosensor allowed us to determine CEA concentrations in the 0.005–50 ng·mL-1 concentration range, with a detection limit of 1.8 pg·mL-1.

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“…Quantum confinement confers different properties to quantum dots with respect to larger particles. Thereby, they have remarkable optical properties, suitable to be used as labels for sensing elements [32].…”

Section: E Nanomaterial-based Biosensorsmentioning

confidence: 99%

A Self-Contained System With CNTs-Based Biosensors for Cell Culture Monitoring

Boero

Olivo

Carrara

et al. 2012

IEEE J. Emerg. Sel. Topics Circuits Syst.

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Abstract-Biosensors have been applied to disparate fields, especially for endogenous compounds such as glucose and lactate. The main areas of application are certainly related to medical and diagnostic purposes. However, metabolic monitoring can be also of interest in cell analysis. Cells can be cultivated for several purposes, such as understanding and modeling some biological mechanisms, the development of new drugs and therapies, or in the field of regenerative medicine. All the aforementioned applications require a thorough knowledge of the biological system under study. In this paper, we propose the development of a self-contained system based on electrochemical biosensors for cell culture monitoring. The detection is based on oxidases immobilized onto carbon nanotubes. We also develop an architecture to record the signal generated by the biosensor and transmit it to a remote station by means of a Bluetooth module. We calibrate the system for glucose and lactate detection in phosphate buffer solution. We achieve a sensitivity of 55.5 and a detection limit of 2 for glucose, as well as a sensitivity of 25.0 and a detection limit of 11 for lactate. We finally validate the two biosensors for metabolic monitoring in culture medium and we detect lactate production in neuroblastoma cells after 72 h of cultivation. The integrated system proposed in the present work opens new opportunities towards the development of novel tools for cell analysis.

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Recent advances and applications in QDs-based sensors

Cited by 123 publications

References 93 publications

A novel signal-off electrochemiluminescence biosensor for the determination of glucose based on double nanoparticles

A novel signal-off electrochemiluminescence biosensor for the determination of glucose based on double nanoparticles

Preparation of Fe3O4@C@CNC multifunctional magnetic core/shell nanoparticles and their application in a signal-type flow-injection photoluminescence immunosensor

A Self-Contained System With CNTs-Based Biosensors for Cell Culture Monitoring

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