Recent advances and future challenges in the synthesis of 2,4,6-triarylpyridines

Abstract

2,4,6-Triarylpyridines are key building blocks to access functional molecules that are used in the design of advance materials, metal-organic frameworks, supramolecules, reactive chemical intermediates and drugs. A number of synthetic...

Visible-light-mediated β-acylative divergent alkene difunctionalization with Katritzky salt/CO2

“…Notably, in all these examples, the by-product 2,4,6-triphenylpyridine was recovered in quantitative amounts, which is a valuable compound for its limited synthetic methods and an important substrate for other organic transformations (Table 2). 26…”

Copper catalysed oxidative cascade deamination/cyclization of vinyl azide and benzylamine for the synthesis of 2,4,6-triarylpyridines

“…However, several starting materials such as aryl ketones, β-nitrostyrenes or alkynes have been introduced to achieve the desired multi-substituted pyridine scaffolds. 6 Regarding this, various reaction partners such as amino acids, 7 arylmethanes, 8 aldehydes, 9 and alkynones 10 have been exploited to a larger extent. In this case, benzyl amines are found to be effective synthons to afford the corresponding 2,4,6-triaryl pyridines under different conditions.…”

TMSOTf-mediated Kröhnke pyridine synthesis using HMDS as the nitrogen source under microwave irradiation

“…Most Chichibabin-type TAP synthetic approaches start from acetophenones with benzaldehydes in the presence of ammonium acetate and are catalyzed by a variety of catalysts. 15,16,19 Among these, the synthetic routes for the synthesis of symmetrical TAPs not only involve the Chichibabin reaction but also methods with fixed nitrogen on starting materials such as benzylamines 20 or oxime acetates. 21 For the preparation of symmetrical TAPs, chalcones are usually applied as the starting material or paired with condensable synthons from various ammonia sources.…”

“… 14 Considering the versatile functions of TAPs in the fields of organic synthesis and medicinal chemistry, the synthetic protocols of TAPs are still of great interest. 15 …”