Recent Advances and Future Perspectives of Triazole Analogs as Promising Antiviral Agents

Abstract

Emergence of severe viral infections in recent years and limited availability of antiviral chemotherapeutic agents for prevention and treatment of these infections are among the most common causes of human illness and death. Therefore, there is an urgent need to develop antiviral drugs that have a potentially critical role in the prevention and treatment of various fatal and debilitating viral infections. Triazole derivatives occupy a pivotal position in modern medicinal chemistry and several have found applications as medicines. A large volume of research has been carried out on triazole and their derivatives for antiviral activity and pharmacological importance of this scaffold has been well established. This review is primarily addressed to description of the recent advances in the synthesis and evaluation of triazole derivatives as antiviral agents which may facilitate the development of more potent and effective antiviral agents.

Medicinal significance of benzothiazole scaffold: an insight view

“…AIDS is now a pandemic. In 2007, it was estimated by World Health Organisation (WHO) that 33.2 million people lived with the disease worldwide, and that AIDS killed an estimated 2.1 million people, including 330,000 children 92 . In the past two and half decades, various compounds have been developed as medicinal candidates for the treatment of HIV infections aiming at one or several steps of the HIV-1 life cycle such as absorption, entry, fusion, un-coating, reverse transcription, integration, transcription and maturation 93 .…”

Design, Synthesis, Structure–Activity Relationships, and Docking Studies of 1‐(γ‐1,2,3‐Triazol Substituted Prolyl)‐(S)‐3,3‐Difluoropyrrolidines as a Novel Series of Potent and Selective Dipeptidyl Peptidase‐4 Inhibitors

“…One strategy to solve this problem is to replace the prolinenitrile as 3,3‐difluoropyrrolidine. The 1,2,3‐triazole ring is a quite stable five‐membered heterocycle (17–21). It is also an important bioisostere of imidazole, oxazole, pyrazole, thiazole, amide moiety, etc., in designing pharmaceutical molecules.…”

Synthesis and biological evaluation of novel benzothiazole clubbed fluoroquinolone derivatives

“…Looking at the importance of these heterocyclic nuclei, it is thought of interest to accommodate 2-aminobenzothiazoles and fluoroquinolones in single molecular framework and screen them for their various biological activities. Due to our continuous interest [23][24][25][26] and research program on design and synthesis of novel anti-microbial agents a number of potent fluoroquinolone derivatives [27][28][29] have been synthesized. Recently, we have reported synthesis of novel fluoroquinolone derivatives annulated with benzothiazoles with promising anti-bacterial activity 30 .…”