Recent Advances and Multiple Strategies of Monoterpenoid Overproduction in <i>Saccharomyces cerevisiae</i> and <i>Yarrowia lipolytica</i>

Li, Dong-Xun; Guo, Qi; Yang, Yu-Xin; Jiang, Shun-Jie; Ji, Xiao-Jun; Ye, Chao; Wang, Yue-Tong; Shi, Tian-Qiong

doi:10.1021/acssynbio.4c00297

ACS Synth. Biol.

2024

DOI: 10.1021/acssynbio.4c00297

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Recent Advances and Multiple Strategies of Monoterpenoid Overproduction in Saccharomyces cerevisiae and Yarrowia lipolytica

Dong-Xun Li,

Qi Guo,

Yu-Xin Yang

et al.

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2024

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Identification and Characterization of a Fungal Monoterpene Synthase Responsible for the Biosynthesis of Geraniol

Zeng,

Meng

et al. 2024

J. Agric. Food Chem.

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Geraniol, an acyclic monoterpenoid of substantial value extracted from the essential oils of various aromatic plants, holds significant commercial and industrial importance in the realms of food, cosmetics, medicine, and bioenergy. Geraniol synthase, which is responsible for geraniol production, has been identified in only several plant species to date. Here, we present the first cloning and characterization of a geraniol synthase (PgfTPS) from Penicillium griseofulvum. This enzyme demonstrates pronounced specificity in catalyzing the conversion of geranyl diphosphate into geraniol. Moreover, through protein modeling and site-directed mutagenesis, we have identified key active-site residues crucial for the catalytic function of PgfTPS. Finally, we utilized engineered Saccharomyces cerevisiae as a host for PgfTPS expression to facilitate geraniol production. Our findings not only advance the development of efficient biocatalysts for geraniol generation but also establish a fundamental basis for further exploration into fungal monoterpene biosynthesis.

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Identification and Characterization of a Fungal Monoterpene Synthase Responsible for the Biosynthesis of Geraniol

Zeng,

Meng

et al. 2024

J. Agric. Food Chem.

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show abstract

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Recent Advances and Multiple Strategies of Monoterpenoid Overproduction in Saccharomyces cerevisiae and Yarrowia lipolytica

Cited by 1 publication

References 118 publications

Identification and Characterization of a Fungal Monoterpene Synthase Responsible for the Biosynthesis of Geraniol

Identification and Characterization of a Fungal Monoterpene Synthase Responsible for the Biosynthesis of Geraniol

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