2023
DOI: 10.1038/s41598-023-34624-8
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Recent advances and new perspectives in mitochondrial dysfunction

Abstract: In the last decade, there has been an increased appreciation for mitochondria as central hubs in diverse processes, such as cellular energy, immunity, and signal transduction. As such, we have become aware that mitochondrial dysfunction underlies many diseases, including primary (mutations in genes encoding mitochondrial proteins) and secondary mitochondrial diseases (mutations in non-mitochondrial genes critical for mitochondrial biology), as well as complex diseases with mitochondrial dysfunction (chronic or… Show more

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Cited by 10 publications
(3 citation statements)
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“…al, 2015). Since mitochondria is an important cell organelle, which supplies energy to the cells for their normal functioning, any alteration would change the cellular metabolism and hinder the normal functioning (Giulivi C et. al, 2023).…”
Section: Discussionmentioning
confidence: 99%
“…al, 2015). Since mitochondria is an important cell organelle, which supplies energy to the cells for their normal functioning, any alteration would change the cellular metabolism and hinder the normal functioning (Giulivi C et. al, 2023).…”
Section: Discussionmentioning
confidence: 99%
“…Mitochondrial dysfunction is a core feature of many chronic diseases, including neurodegenerative and neurodevelopmental diseases, metabolic diseases, autoimmune diseases and cancer [5,6]. It therefore behooves the cell to minimize the number of deuterium atoms in the mitochondrial water, to the extent that this is possible.…”
Section: Introductionmentioning
confidence: 99%
“…Mitochondria have always been the focus of research for chemists and biologists, and many diseases related to cancer are closely related to mitochondrial dysfunction. 1 Nucleic acid carries important genetic information in organisms, and except for its classical double helix configuration, it can also form non-classical nucleic acid secondary structures such as G4s. G4s are usually formed by the binding of guanine rich DNA through Hoogsteen hydrogen bonds.…”
mentioning
confidence: 99%