“…The development of clean technologies that replace hazardous organic solvents with environmentally friendly solvents has become increasingly popular in recent years. 8 Owing to this new challenge, organic synthesis has become increasingly popular under solvent-free conditions, as "green chemistry" strives to minimize pollution, costs, and tedious procedures. 9,10 In synthetic organic chemistry, multicomponent reactions (MCRs) are becoming increasingly popular for their many advantages, including increased atom economy, simplicity, structural disparity, energy savings, and waste reduction.…”