Recent advances for enhanced photodynamic therapy: from new mechanisms to innovative strategies

Wang, Xia; Peng, Jinlei; Meng, Chi; Feng, Fude

doi:10.1039/d3sc07006a

Chem. Sci.

2024

DOI: 10.1039/d3sc07006a

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Recent advances for enhanced photodynamic therapy: from new mechanisms to innovative strategies

Xia Wang,

Jinlei Peng,

Chi Meng

et al.

Abstract: Photodynamic therapy (PDT) has been developed as a potential cancer treatment approach owing to its non-invasiveness, spatiotemporal control and limited side effects. Currently, great efforts have been made to improve...

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Cited by 6 publications

References 155 publications

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Auto‐Deactivation of BODIPY‐Derived Type I Photosensitizer Post Photodynamic Therapy under Hypoxia

Wang,

Hang

et al. 2024

ChemBioChem

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The long‐lasting activity of photosensitizers during photodynamic therapy (PDT) causes excessive damage and arouses great concerns about biosafety. Herein, we synthesized a pyridinium‐decorated diiodo‐BODIPY compound (PyBDP) and investigated its photosensitizing activity under hypoxic condition in the presence of NADH that is abundant in the mitochondria of hypoxic tumors. The unique property of PyBDP lies in the redox environment‐dependent photo‐response. At green light exposure, PyBDP is converted into a colorless inactive form by interacting with NADH in a two‐step one‐electron transfer process. Interestingly, the NADH‐dependent hydrogenation of PyBDP is affected by the presence of cytochrome c (Cyt cox) that is an important component of mitochondrial electron transport chain (Mito‐ETC), unless Cyt cox is exhausted. Active radical species is produced during the photocatalytic reaction, which adds the understanding of PyBDP‐induced photodamage. Therefore, we applied the strategy of auto‐deactivation PDT using a BODIPY photosensitizer by tethering triphenylphosphonium to PyBDP. After PDT effect in a type I pathway, the photosensitizer underwent almost entire auto‐deactivation in hypoxic HeLa cells. This work paves a way for the development of reductive PDT with enhanced safety and efficacy in fighting hypoxic tumors independent on reactive oxygen species (ROS).

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Auto‐Deactivation of BODIPY‐Derived Type I Photosensitizer Post Photodynamic Therapy under Hypoxia

Wang,

Hang

et al. 2024

ChemBioChem

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Enhancing Near‐Infrared Absorption in Osmium(II) Complexes Under the Cumulative Influence of Terpyridine Ligand and Anions: Combined Experimental and DFT/TD‐DFT Investigation

Bhattacharya,

Pal,

Gorain

et al. 2024

Eur J Inorg Chem

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This work presents synthesis, characterization, and thorough examination on the photophysical and electrochemical behaviours of a new class of homo‐ and heteroleptic Os(II)‐terpyridine complexes. The compounds exhibit intense singlet metal‐to‐ligand charge‐transfer (1MLCT) bands in the visible region (490–500 nm) and weak and broad spin‐forbidden bands in the spectral window of 670–680 nm due to singlet ground state (1GS) to 3MLCT state transition, facilitated by spin‐orbit coupling. The complexes exhibit strong luminescence within 730–750 nm at room temperature having lifetimes in the domain of 101–158 ns, depending upon solvents. Taking advantage of active methylene protons, anion‐induced modulation of spectral and electrochemical characteristics of the complexes has been convincingly demonstrated via different optical channels and spectroscopic tools as well as by cyclic voltammetry. The augmentation in absorption spectral characteristics is quite remarkable in presence of F− and intense absorption bands spanning across the entire visible region and stretching up to NIR domain is achieved. The mode of complex‐anion interplay was elucidated via 1H, 31P{1H} and 19F NMR spectroscopy as well as by computational investigations using DFT and TD‐DFT methods. The complexes also act as molecular sensors and switches that can function in visible and NIR domains upon alternate addition of anion and acid.

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Evaluation of the antineoplastic properties of the photosensitizer biscyanine in 2D and 3D tumor cell models and artificial skin models

Resende,

Gomes,

Peixoto

et al. 2025

Journal of Photochemistry and Photobiology B: Biology

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Recent advances for enhanced photodynamic therapy: from new mechanisms to innovative strategies

Abstract: Photodynamic therapy (PDT) has been developed as a potential cancer treatment approach owing to its non-invasiveness, spatiotemporal control and limited side effects. Currently, great efforts have been made to improve...

Cited by 6 publications

References 155 publications

Auto‐Deactivation of BODIPY‐Derived Type I Photosensitizer Post Photodynamic Therapy under Hypoxia

Auto‐Deactivation of BODIPY‐Derived Type I Photosensitizer Post Photodynamic Therapy under Hypoxia

Enhancing Near‐Infrared Absorption in Osmium(II) Complexes Under the Cumulative Influence of Terpyridine Ligand and Anions: Combined Experimental and DFT/TD‐DFT Investigation

Evaluation of the antineoplastic properties of the photosensitizer biscyanine in 2D and 3D tumor cell models and artificial skin models

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