Recent Advances for Improving Functionality, Biocompatibility, and Longevity of Implantable Medical Devices and Deliverable Drug Delivery Systems (Adv. Funct. Mater. 44/2021)

Enhancing the Management of Metastatic Tumors by Robust Co‐Delivery of 5‐Fluorouracil/MicroRNA‐10b Inhibitor Using EGFR‐Targeted Nanovehicles

“…The combination therapy of chemotherapy and nucleotide drugs for anticancer has been quite attractive, as the progress of nanovehicle technology has made it possible to co‐deliver different bioactive therapeutic molecules in a “two‐in‐one” strategy. [ 45 ] GCD nanovehicles showed a considerable promise as anticancer drug carriers via the highly effective combined delivery of 5‐FU and Anti‐miR‐10b. In addition, GCD nanovehicle‐mediated treatment could be used for various types of cancer, as combination regimens are typically used to improve therapeutic efficacy in clinical solid tumors treatment.…”

“…This multifunctional nanovehicle can be used for the efficient co‐delivery of small molecular and nucleotide drugs simultaneously and for achieving comprehensive treatment. [ 14 ] Furthermore, RGD peptides can be replaced by other types of functional peptides, which can be applied in different scenarios. These unique features of our nanovehicle meet the aforementioned requirements for treating CRC, particularly for the inhibition of metastasis.…”

Evolution of Musculoskeletal Electronics

“…Moreover, state‐of‐the‐art devices have also been exploited to enhance function or restore the integrity of the musculoskeletal system, and have the potential to accelerate the healing process with electrical stimulation, drug‐releasing designs, or prosthetic nerve probes. [ 14 ] Although the musculoskeletal electronics have much in common in signal detection and monitoring with bioelectronic sensors, they are different since bioelectronic sensors are more focus on detecting and monitor biological signals, whereas musculoskeletal electronics also involves specific interaction between devices and musculoskeletal system, such as prosthetic limbs, exoskeletons, or implantable devices that assist with movement.…”

Poly(Glutamic Acid‐Lysine) Hydrogels with Alternating Sequence Resist the Foreign Body Response in Rodents and Non‐Human Primates

“…[ 4 , 5 , 6 ] However, the foreign body response (FBR) triggered by these implanted materials can lead to fibrotic encapsulation, compromising the efficacy of implants and giving rise to complications. [ 7 , 8 , 9 , 10 , 11 , 12 , 13 ] The FBR can be elicited by a wide range of materials employed in the fabrication of biomedical devices, irrespective of whether they are composed of metals, inorganics, or natural and synthetic polymers. [ 14 , 15 , 16 , 17 ] Surprisingly, even materials conventionally known for their favorable biocompatibility, such as hydrophilic polymers like polyethylene glycol (PEG) and poly(2‐hydroxyethyl methacrylate), have been found to evoke strong FBR.…”