Recent advances in activatable NIR-II organic fluorophores for biomedical applications

Xu, Yanzi; Zhang, Peijuan; Gao, Anran; Xu, Ruohan; Wang, Zhi; Shen, Qifei; Zhao, Zhiqin; Meng, Lingjie; Dang, Dongfeng

doi:10.1039/d2qm01120d

Cited by 16 publications

(5 citation statements)

References 119 publications

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“…Second, compared with always‐on bioimaging, activatable/specific targeted fluorescence imaging can image specific overexpressed biomarkers or specific lesion regions, facilitate the differentiation between diseased and normal tissues, and avoid false‐positive phenomena, which exhibit a higher signal‐to‐background ratio. [ 111 ] At the same time, compared to bioimaging relying on prolonged retention (e.g., passive accumulation occurs at the tumor site via the enhanced permeation and retention (EPR) effect), activatable and targeted imaging can reduce organ burden and side effects. Therefore, the development of fluorescent probes such as tumor microenvironment‐targeted, inflammation/disease factor‐activated fluorescent probes hold immense importance for tumor imaging and disease diagnosis.…”

Section: Discussionmentioning

confidence: 99%

2, 1, 3‐Benzothiadiazole Derivative Small Molecule Fluorophores for NIR‐II Bioimaging

Hu,

Feng,

Yang

2024

Adv Funct Materials

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Second near‐infrared (NIR‐II) bioimaging technology shows broad application prospects in the field of biomedical due to its significant superiority in deep tissue penetration and high signal‐to‐background ratio. Among them, organic small molecule fluorophores have received progressively more consideration due to their low biotoxicity, high biocompatibility, rapid clearance, and good modification properties. As the key acceptor core, 2, 1, 3‐benzothiadiazole (BTD) derivative plays an essential role in the construction of donor‐acceptor‐donor type NIR‐II fluorophores. This mini‐review summarizes the research development of NIR‐II small molecule fluorophores based on BTD derivatives in the field of bioimaging, focusing on molecular design and photophysical properties, and introduces a part of the applications in the biological field. Furthermore, the challenges of BTD‐based NIR‐II fluorophores in the future development and application are discussed .

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Section: Discussionmentioning

confidence: 99%

2, 1, 3‐Benzothiadiazole Derivative Small Molecule Fluorophores for NIR‐II Bioimaging

Hu,

Feng,

Yang

2024

Adv Funct Materials

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“…Yet, due to the ever developing area of superresolution imaging microscopy further challenges arose, which provoked the exploration of novel design strategies and smart solutions to develop non-invasive methods for the imaging of live cells or more complex structures to approach the resolution of electron microscopy. To increase the translational value of such bioorthogonal imaging techniques, effective modulation of probes in the NIR-I/NIR-II range is necessary [ 129 ]. To this end, design strategies not relying on quenching mechanisms need to be explored in the context of NIR emitting cores [ 130 ].…”

Section: Discussionmentioning

confidence: 99%

Bioorthogonal Reactions in Bioimaging

Kozma,

Kele

2024

Top Curr Chem (Z)

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Visualization of biomolecules in their native environment or imaging-aided understanding of more complex biomolecular processes are one of the focus areas of chemical biology research, which requires selective, often site-specific labeling of targets. This challenging task is effectively addressed by bioorthogonal chemistry tools in combination with advanced synthetic biology methods. Today, the smart combination of the elements of the bioorthogonal toolbox allows selective installation of multiple markers to selected targets, enabling multicolor or multimodal imaging of biomolecules. Furthermore, recent developments in bioorthogonally applicable probe design that meet the growing demands of superresolution microscopy enable more complex questions to be addressed. These novel, advanced probes enable highly sensitive, low-background, single- or multiphoton imaging of biological species and events in live organisms at resolutions comparable to the size of the biomolecule of interest. Herein, the latest developments in bioorthogonal fluorescent probe design and labeling schemes will be discussed in the context of in cellulo/in vivo (multicolor and/or superresolved) imaging schemes. The second part focuses on the importance of genetically engineered minimal bioorthogonal tags, with a particular interest in site-specific protein tagging applications to answer biological questions.

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“… In pursuit of enhancing the multiple diagnostic and therapeutic performance of TME‐activated NIR‐II phototheranostic agents [5e,13] . The current approach usually relies on a multi‐component encapsulation nanoplatform.…”

Section: Discussionmentioning

confidence: 99%

Recent Progress on Tumor Microenvironment‐Activated NIR‐II Phototheranostic Agents with Simultaneous Activation for Diagnosis and Treatment

Xiao,

Wu,

Tan

et al. 2024

Chemistry An Asian Journal

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Malignant tumors seriously threaten human life and well‐being. Emerging Near‐infrared II (NIR‐II, 1000‐1700 nm) phototheranostic nanotechnology integrates diagnostic and treatment modalities, offering merits including improved tissue penetration and enhanced spatiotemporal resolution. This remarkable progress has opened promising avenues for advancing tumor theranostic research. The tumor microenvironment (TME) differs from normal tissues, exhibiting distinct attributes such as hypoxia, acidosis, overexpressed hydrogen peroxide, excess glutathione, and other factors. Capitalizing on these attributes, researchers have developed TME‐activatable NIR‐II phototheranostic agents with diagnostic and therapeutic attributes concurrently. Therefore, developing TME‐activatable NIR‐II phototheranostic agents with diagnostic and therapeutic activation holds significant research importance. Currently, research on TME‐activatable NIR‐II phototheranostic agents is still in its preliminary stages. This review examines the recent advances in developing dual‐functional NIR‐II activatable phototheranostic agents over the past years. It systematically presents NIR‐II phototheranostic agents activated by various TME factors such as acidity (pH), hydrogen peroxide (H2O2), glutathione (GSH), hydrogen sulfide (H2S), enzymes, and their hybrid. This encompasses NIR‐II fluorescence and photoacoustic imaging diagnostics, along with therapeutic modalities, including photothermal, photodynamic, chemodynamic, and gas therapies triggered by these TME factors. Lastly, the difficulties and opportunities confronting NIR‐II activatable phototheranostic agents in the simultaneous diagnosis and treatment field are highlighted.

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Recent advances in activatable NIR-II organic fluorophores for biomedical applications

Abstract: Fluorescence imaging in the second near-infrared region (NIR-II) exhibits great potentials in intravital imaging and analysis due to its high penetration depth and low photo-damage. However, traditional organic fluorophores usually...

Cited by 16 publications

References 119 publications

2, 1, 3‐Benzothiadiazole Derivative Small Molecule Fluorophores for NIR‐II Bioimaging

2, 1, 3‐Benzothiadiazole Derivative Small Molecule Fluorophores for NIR‐II Bioimaging

Bioorthogonal Reactions in Bioimaging

Recent Progress on Tumor Microenvironment‐Activated NIR‐II Phototheranostic Agents with Simultaneous Activation for Diagnosis and Treatment

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