Recent Advances in Adipose Tissue Dysfunction and Its Role in the Pathogenesis of Non-Alcoholic Fatty Liver Disease

Wang, Xiaoxiao; Rao, Huiying; Liu, Feng; Wei, Lai; Li, Honggui; Wu, Chaodong

doi:10.3390/cells10123300

Cited by 35 publications

(20 citation statements)

References 145 publications

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“…Obesity leads to low-grade systemic inflammation with consequent insulin resistance and other metabolic disorders. Visceral fat, as well as that accumulated in the liver, heart, and muscles, increases the risk of type 2 diabetes mellitus (DM2), cardiovascular disease (CVD), asthma, and some types of cancer [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…This condition can lead to nonalcoholic steatohepatitis (NASH), characterized by steatosis, inflammation, and liver damage, with or without fibrosis, which can progress to cirrhosis (requiring liver transplantation), hepatocellular carcinoma, and death. Hepatic inflammatory status appears to be the key factor in the progression from NAFLD to NASH [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Obese Vegetarians and Omnivores Show Different Metabolic Changes: Analysis of 1340 Individuals

et al. 2022

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Our study evaluated the association between the increase in body mass index (BMI) in men and women (menstruating and non-menstruating) (n = 1340) with different dietary groups (omnivores, semi-vegetarians, lacto-ovo-vegetarian, and vegans) and the measurement of the biochemical markers high-sensitive C-reactive protein (hs-CRP), ferritin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), glycated hemoglobin (HbA1C), and insulin resistance index (HOMA-IR). Increasing BMI values in all groups and dietary profiles were related to a significant increase in hs-CRP (p < 0.0001), ALT (p = 0.02), ferritin (p = 0.009), and HbA1C (p < 0.0001), with no difference between dietary groups (p < 0.05). The increase in BMI increases the levels of HOMA-IR (p < 0.0001) and GGT (p < 0.05), with higher values found in men when compared to women (p < 0.0001 for HOMA- IR and p = 0.0048 for GGT). The association between ALT and BMI was different between dietary groups, as it showed a decrease in vegan women who do not menstruate compared to other dietary groups (p = 0.0099). When including only obese individuals (BMI = 30 kg/m2, n = 153) in the analysis, we observed lower concentrations of GGT and ferritin in vegetarians than in omnivores, regardless of gender and menstrual blood loss (p = 0.0395). Our data showed that for both vegetarians and omnivores, the higher the BMI, the worse the metabolic parameters. However, regarding obesity, vegetarians showed better antioxidant status (lower GGT elevation) and lower inflammatory status (lower ferritin elevation), which may provide them with potential protection in the development of morbidities associated with overweight.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Obese Vegetarians and Omnivores Show Different Metabolic Changes: Analysis of 1340 Individuals

et al. 2022

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“…Once the homeostatic status of lipid metabolism is out of balance, excessive fat will accumulate in the liver, which may eventually lead to the development of NAFLD [ 25 ]. Lipid metabolism is affected by a variety of biological processes but mainly includes de novo adipogenesis, fatty acid intake, fatty acid oxidation, and very low-density lipoprotein (VLDL) output [ 26 ]. Once these processes turn into disorders, liver lipid metabolism will be disturbed, as characterized by the excessive accumulation of liver triglycerides (TGs).…”

Section: Acupuncture Improves Lipid Metabolism Disorder In Nafldmentioning

confidence: 99%

Research Progress on the Mechanism of Acupuncture Treatment for Nonalcoholic Fatty Liver Disease

2022

Gastroenterology Research and Practice

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Nonalcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease worldwide, ranging from simple steatosis and nonalcoholic steatohepatitis to fibrosis, cirrhosis, and hepatocellular carcinoma. Acupuncture is a long-established treatment in traditional Chinese medicine. In recent years, increasing evidence has pointed to the effectiveness of acupuncture in the treatment of NAFLD, and a certain degree of progress has been made in the study of related mechanisms. However, previous systematic reviews have not discussed the characteristics and the related mechanisms of acupuncture in the treatment of NAFLD. Therefore, this review synthesizes the progress in research on acupuncture in the context of NAFLD treatment by the inhibition of inflammatory responses, regulation of lipid metabolism disorder, treatment of insulin resistance, antagonization of oxidative stress injury, and interference with endoplasmic reticulum stress. Overall, we sought to highlight the latest research results, potential applications, and ongoing challenges of this therapy.

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“…All these metabolic substrates have been implicated as risk factors for lymphomas [ 141 , 142 ]. Metabolic abnormalities of adipose tissue are associated with chronic inflammation which promotes the production of proinflammatory factors, such as TNF-α, IL-6, and IL-8, and inhibits the secretion of anti-inflammatory factors, such as adiponectin [ 143 , 144 ]. Adiponectin, an adipose tissue specific cytokine that has a protective role against metabolic disturbances in diabetes and obesity, have been reported to suppress lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells [ 145 ].…”

Section: Lymphoma and Metabolic Disorders/diseasesmentioning

confidence: 99%

Second malignant neoplasms in lymphomas, secondary lymphomas and lymphomas in metabolic disorders/diseases

Shi

Wang

et al. 2022

Cell Biosci

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With inconsistent findings, evidence has been obtained in recent years that metabolic disorders are closely associated with the development of lymphomas. Studies and multiple analyses have been published also indicating that some solid tumor survivors develop a secondary lymphoma, whereas some lymphoma survivors subsequently develop a second malignant neoplasm (SMN), particularly solid tumors. An interaction between the multiple etiologic factors such as genetic factors and late effects of cancer therapy may play an important role contributing to the carcinogenesis in patients with metabolic diseases or with a primary cancer. In this review, we summarize the current knowledge of the multiple etiologic factors for lymphomagenesis, focusing on the SMN in lymphoma, secondary lymphomas in primary cancers, and the lymphomas associated to metabolic disorders/diseases, which have been received less attention previously. Further, we also review the data of coexistence of lymphomas and hepatocellular carcinoma (HCC) in patients with infection of hepatitis C virus and hepatitis B virus. Graphical Abstract

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Recent Advances in Adipose Tissue Dysfunction and Its Role in the Pathogenesis of Non-Alcoholic Fatty Liver Disease

Cited by 35 publications

References 145 publications

Obese Vegetarians and Omnivores Show Different Metabolic Changes: Analysis of 1340 Individuals

Obese Vegetarians and Omnivores Show Different Metabolic Changes: Analysis of 1340 Individuals

Research Progress on the Mechanism of Acupuncture Treatment for Nonalcoholic Fatty Liver Disease

Second malignant neoplasms in lymphomas, secondary lymphomas and lymphomas in metabolic disorders/diseases

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