Recent Advances in AIV Biosensors Composed of Nanobio Hybrid Material

Lee, Taek; Ahn, Jae-Hyuk; Park, Sun Yong; Kim, Gahyeon; Kim, Jeonghyun; Kim, Tae-Hyung; Nam, Inho; Park, Chulhwan; Lee, Minho

doi:10.3390/mi9120651

Cited by 32 publications

(21 citation statements)

References 98 publications

(109 reference statements)

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“…2 c) (Mahari et al 2020 ). Surface Plasmon Resonance (SPR) and Localized Surface Plasmon Resonance (LSPR) based viral biosensors were referred earlier (Park et al 2009 ; Lee et al 2018 ). These thermoplasmonic techniques are highly applicable in nucleic-acid detection and also in viral disease diagnosis.…”

Section: Recent Trends In Biosensors For Detection Of Sars-cov-2mentioning

confidence: 99%

Biosensors: frontiers in rapid detection of COVID-19

2020

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The rapid community-spread of novel human coronavirus 2019 (nCOVID19 or SARS-Cov2) and morbidity statistics has put forth an unprecedented urge for rapid diagnostics for quick and sensitive detection followed by contact tracing and containment strategies, especially when no vaccine or therapeutics are known. Currently, quantitative real-time polymerase chain reaction (qRT-PCR) is being used widely to detect COVID-19 from various types of biological specimens, which is time-consuming, labor-intensive and may not be rapidly deployable in remote or resource-limited settings. This might lead to hindrance in acquiring realistic data of infectivity and community spread of SARS-CoV-2 in the population. This review summarizes the existing status of current diagnostic methods, their possible limitations, and the advantages of biosensorbased diagnostics over the conventional ones for the detection of SARS-Cov-2. Novel biosensors used to detect RNA-viruses include CRISPR-Cas9 based paper strip, nucleic-acid based, aptamer-based, antigen-Au/Ag nanoparticles-based electrochemical biosensor, optical biosensor, and Surface Plasmon Resonance. These could be effective tools for rapid, authentic, portable, and more promising diagnosis in the current pandemic that has affected the world economies and humanity. Present challenges and future perspectives of developing robust biosensors devices for rapid, scalable, and sensitive detection and management of COVID-19 are presented in light of the test-test-test theme of the World Health Organization (WHO).

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Section: Recent Trends In Biosensors For Detection Of Sars-cov-2mentioning

confidence: 99%

Biosensors: frontiers in rapid detection of COVID-19

2020

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“…To reduce the number of patients suffering from adverse effects of inappropriate drugs and attain accurate results in a short time, it is necessary to use ultra-sensitive and selective methods [ 54 ]. The novel technology of FET-based biosensors is highly capable of detecting any nano-sized object, like an antibody, biomolecules, pathogens, and even viruses [ 55 ]. Owing to a large amount of hemagglutinin (HA) and neuraminidase (NA) on a viral particle, these glycoproteins are an ideal target for virus detection [ 56 ].…”

Section: Selective Adhesion On Fet For Biosensing Applicationsmentioning

confidence: 99%

Biosensing based on field-effect transistors (FET): Recent progress and challenges

Sadighbayan

Hasanzadeh

Ghafar-Zadeh

2020

TrAC Trends in Analytical Chemistry

208

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The use of field-Effect-Transistor (FET) type biosensing arrangements has been highlighted by researchers in the field of early biomarker detection and drug screening. Their non-metalized gate dielectrics that are exposed to an electrolyte solution cover the semiconductor material and actively transduce the biological changes on the surface. The efficiency of these novel devices in detecting different biomolecular analytes in a real-time, highly precise, specific, and label-free manner has been validated by numerous research studies. Considerable progress has been attained in designing FET devices, especially for biomedical diagnosis and cell-based assays in the past few decades. The exceptional electronic properties, compactness, and scalability of these novel tools are very desirable for designing rapid, label-free, and mass detection of biomolecules. With the incorporation of nanotechnology, the performance of biosensors based on FET boosts significantly, particularly, employment of nanomaterials such as graphene, metal nanoparticles, single and multi-walled carbon nanotubes, nanorods, and nanowires. Besides, their commercial availability, and high-quality production on a large-scale, turn them to be one of the most preferred sensing and screening platforms. This review presents the basic structural setup and working principle of different types of FET devices. We also focused on the latest progression regarding the use of FET biosensors for the recognition of viruses such as, recently emerged COVID-19, Influenza, Hepatitis B Virus, protein biomarkers, nucleic acids, bacteria, cells, and various ions. Additionally, an outline of the development of FET sensors for investigations related to drug development and the cellular investigation is also presented. Some technical strategies for enhancing the sensitivity and selectivity of detection in these devices are addressed as well. However, there are still certain challenges which are remained unaddressed concerning the performance and clinical use of transistor-based point-of-care (POC) instruments; accordingly, expectations about their future improvement for biosensing and cellular studies are argued at the end of this review.

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“…Different types of biosensors for AIV detection use nanobio hybrid materials (reviewed in Lee et al, 2018). In one of those approaches, a DNA probe coupled to a field-effect transistor enabled detection of target DNA down to 1 fM (Lin et al, 2009).…”

Section: Innovative Approaches For Future Pocts Biosensorsmentioning

confidence: 99%