Recent advances in amino acid-based electrode fabrication strategies for enhanced electrochemical detection of metal ions

Tang, Liang Wei; Alias, Yatimah; Jiwanti, Prastika Krisma; Woi, Pei Meng

doi:10.1016/j.teac.2024.e00225

Trends in Environmental Analytical Chemistry

2024

DOI: 10.1016/j.teac.2024.e00225

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Recent advances in amino acid-based electrode fabrication strategies for enhanced electrochemical detection of metal ions

Liang Wei Tang,

Yatimah Alias,

Prastika Krisma Jiwanti

et al.

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Cited by 3 publications

References 49 publications

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Advancing overall water splitting via phase-engineered amorphous/crystalline interface: A novel strategy to accelerate proton-coupled electron transfer

Feng,

Han,

Wang

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Journal of Colloid and Interface Science

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Advancing overall water splitting via phase-engineered amorphous/crystalline interface: A novel strategy to accelerate proton-coupled electron transfer

Feng,

Han,

Wang

et al. 2024

Journal of Colloid and Interface Science

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An ultrasensitive electrochemical sensor for the simultaneous detection of baicalin and baicalein in pharmaceuticals and serum samples

Zhang,

Liu

2025

Talanta

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Label-Free Mode Based on Ferrocene/PEDOT:PSS–PPy for Molecularly Imprinted Electrochemically Ultrasensitive Detection of Amino Acids

Wang,

Chen,

et al. 2024

Anal. Chem.

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Generally, molecularly imprinted (MIP) electrochemical sensors for amino acids operate in a "label-like" mode. That is, after an amino acid is specifically recognized by an imprinted cavity at the sensing interface, the amino acid itself provides the sensing signal for quantitative detection. However, poorly electroactive amino acids impede electron transfer at the sensing interface and require high potentials to drive the reaction; thus, more interfering reactions tend to be triggered in practical applications, causing enhanced background noise in the detection. To address these issues, a "label-free" mode of the MIP sensor based on the ferrocene (Fc)/PEDOT:PSS-polypyrrole (PPy) composite was designed for the first time. The Fc/PE-DOT:PSS−PPy is drop coated on the electrode surface as a substrate, and MIP polymers with specific recognition ability are immobilized on the substrate via electrostatic adsorption. As a proof of concept, L-tyrosine (L-Tyr) was selected as a model analyte and the "label-free" mode MIP/Fc/PEDOT:PSS−PPy sensor was constructed. The limit of detection (LOD) and linearity range of the MIP/Fc/PEDOT:PSS−PPy sensor were 2.31 × 10 −11 M and from 100 pM to 5 mM, respectively. Compared with the label-like mode, the LOD was three orders of magnitude lower, the linear range was increased by three orders of magnitude, and the sensitivity was improved by more than four times. This work provides a universal and effective concept for MIP electrochemical sensing of amino acids.

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Recent advances in amino acid-based electrode fabrication strategies for enhanced electrochemical detection of metal ions

Cited by 3 publications

References 49 publications

Advancing overall water splitting via phase-engineered amorphous/crystalline interface: A novel strategy to accelerate proton-coupled electron transfer

Advancing overall water splitting via phase-engineered amorphous/crystalline interface: A novel strategy to accelerate proton-coupled electron transfer

An ultrasensitive electrochemical sensor for the simultaneous detection of baicalin and baicalein in pharmaceuticals and serum samples

Label-Free Mode Based on Ferrocene/PEDOT:PSS–PPy for Molecularly Imprinted Electrochemically Ultrasensitive Detection of Amino Acids

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