Recent Advances in Antimicrobial Hydrogels Containing Metal Ions and Metals/Metal Oxide Nanoparticles

Wahid, Fazli; Zhong, Cheng; Wang, Haisong; Hu, Xiaohui; Chu, Li‐Qiang

doi:10.3390/polym9120636

Cited by 147 publications

(78 citation statements)

References 170 publications

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“…non-antimicrobial hydrogels in order to confer antimicrobial properties. Incorporation of some metallic ions can also confer catalytic, photo-responsive, photochemical, redox, and conductive properties to hydrogels (Wahid et al, 2017). In agriculture, the use of chitosan nanoparticles are of special interest due to its immune-modulatory activity elicited in plants.…”

Section: Nanogelsmentioning

confidence: 99%

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Vega-Vásquez

Mosier

Irudayaraj

2020

Front. Bioeng. Biotechnol.

210

107

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The main challenges in drug delivery systems are to protect, transport and release biologically active compounds at the right time in a safe and reproducible manner, usually at a specific target site. In the past, drug nano-carriers have contributed to the development of precision medicine and to a lesser extent have focused on its inroads in agriculture. The concept of engineered nano-carriers may be a promising route to address confounding challenges in agriculture that could perhaps lead to an increase in crop production while reducing the environmental impact associated with crop protection and food production. The main objective of this review is to contrast the advantages and disadvantages of different types of nanoparticles and nano-carriers currently used in the biomedical field along with their fabrication methods to discuss the potential use of these technologies at a larger scale in agriculture. Here we explain what is the problem that nano-delivery systems intent to solve as a technological platform and describe the benefits this technology has brought to medicine. Also here we highlight the potential drawbacks that this technology may face during its translation to agricultural applications, based on the lessons learned so far from its use for biomedical purposes. We discuss not only the characteristics of an ideal nano-delivery system, but also the potential constraints regarding the fabrication including technical, environmental, and legal aspects. A key motivation is to evaluate the potential use of these systems in agriculture, especially in the area of plant breeding, growth promotion, disease control, and post-harvest quality control. Further, we highlight the importance of a rational design of nano-carriers and identify current research gaps to enable scale-up relevant to applications in the treatment of plant diseases, controlled release of fertilizers, and plant breeding.

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Section: Nanogelsmentioning

confidence: 99%

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Vega-Vásquez

Mosier

Irudayaraj

2020

Front. Bioeng. Biotechnol.

210

107

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“…Metal-based antimicrobials, such as nanoparticles, generally highlighted for their elevated toxicity, are seeing an increase in development and use [15,25,26,27]. A number of metal infused hydrogels and polymers, which provide slow and concentrated release, have been developed and tested against microorganisms [28,29]. Moreover, metals are being combined with existing antimicrobials, such as antibiotics, as a means of improving their efficacy and repurposing agents that are no longer useful against multidrug resistant bacteria [30,31].…”

Section: Introductionmentioning

confidence: 99%

Specificity in the Susceptibilities of Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus Clinical Isolates to Six Metal Antimicrobials

Gugala

Parkins

et al. 2019

Antibiotics

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In response to the occurrence of antibiotic resistance, there has been rapid developments in the field of metal-based antimicrobials. Although it is largely assumed that metals provide broad-spectrum microbial efficacy, studies have shown that this is not always the case. Therefore, in this study, we compared the susceptibilities of 93 clinical isolates belonging to the species Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus against six metals, namely aluminum, copper, gallium, nickel, silver and zinc. To provide qualitative comparative information, the resulting zones of growth inhibition were compared to the minimal inhibitory concentrations of three indicator strains E. coli ATCC 25922, P. aeruginosa ATCC 27853 and S. aureus ATCC 25923. Here, we demonstrate that the metal efficacies were species- and isolate-specific. Only several isolates were either resistant or sensitive to all of the six metals, with great variability found between isolates. However, the greatest degree of similarity was found with the E. coli isolates. In contrast, the susceptibilities of the remaining two collections, S. aureus and P. aeruginosa, were more highly dispersed. Using this information, we have shown that metals are not equal in their efficacies. Hence, their use should be tailored against a particular microorganism and care should be taken to ensure the use of the correct concentration.

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“…Copper oxide is a metal oxide with the ability to target various bacterial structures and its antimicrobial activity can be further improved on the nanoscale. Due to their excellent properties, CuO NPs have attracted great interest from the healthcare, food packaging, medical, and environmental industries [ 120 , 134 ]. This metal oxide is capable of disrupting the normal function of the cell membrane, changing its permeability and the cellular respiration process [ 135 ].…”

Section: Reviewmentioning

confidence: 99%

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

Correa

Martínez

Vidal

et al. 2020

Beilstein J. Nanotechnol.

115

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The investigation of novel nanoparticles with antimicrobial activity has grown in recent years due to the increased incidence of nosocomial infections occurring during hospitalization and food poisoning derived from foodborne pathogens. Antimicrobial agents are necessary in various fields in which biological contamination occurs. For example, in food packaging they are used to control food contamination by microbes, in the medical field the microbial agents are important for reducing the risk of contamination in invasive and routine interventions, and in the textile industry, they can limit the growth of microorganisms due to sweat. The combination of nanotechnology with materials that have an intrinsic antimicrobial activity can result in the development of novel antimicrobial substances. Specifically, metal-based nanoparticles have attracted much interest due to their broad effectiveness against pathogenic microorganisms due to their high surface area and high reactivity. The aim of this review was to explore the state-of-the-art in metal-based nanoparticles, focusing on their synthesis methods, types, and their antimicrobial action. Different techniques used to synthesize metal-based nanoparticles were discussed, including chemical and physical methods and “green synthesis” methods that are free of chemical agents. Although the most studied nanoparticles with antimicrobial properties are metallic or metal-oxide nanoparticles, other types of nanoparticles, such as superparamagnetic iron-oxide nanoparticles and silica-releasing systems also exhibit antimicrobial properties. Finally, since the quantification and understanding of the antimicrobial action of metal-based nanoparticles are key topics, several methods for evaluating in vitro antimicrobial activity and the most common antimicrobial mechanisms (e.g., cell damage and changes in the expression of metabolic genes) were discussed in this review.

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Recent Advances in Antimicrobial Hydrogels Containing Metal Ions and Metals/Metal Oxide Nanoparticles

Cited by 147 publications

References 170 publications

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Specificity in the Susceptibilities of Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus Clinical Isolates to Six Metal Antimicrobials

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

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